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637 related items for PubMed ID: 16734383

  • 1. Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.
    Dunford JE, Rogers MJ, Ebetino FH, Phipps RJ, Coxon FP.
    J Bone Miner Res; 2006 May; 21(5):684-94. PubMed ID: 16734383
    [Abstract] [Full Text] [Related]

  • 2. Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo.
    Coxon FP, Ebetino FH, Mules EH, Seabra MC, McKenna CE, Rogers MJ.
    Bone; 2005 Sep; 37(3):349-58. PubMed ID: 16006204
    [Abstract] [Full Text] [Related]

  • 3. Nitrogen-containing bisphosphonate mechanism of action.
    Reszka AA, Rodan GA.
    Mini Rev Med Chem; 2004 Sep; 4(7):711-9. PubMed ID: 15379639
    [Abstract] [Full Text] [Related]

  • 4. Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.
    Coxon FP, Thompson K, Roelofs AJ, Ebetino FH, Rogers MJ.
    Bone; 2008 May; 42(5):848-60. PubMed ID: 18325866
    [Abstract] [Full Text] [Related]

  • 5. Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
    Coxon FP, Helfrich MH, Van't Hof R, Sebti S, Ralston SH, Hamilton A, Rogers MJ.
    J Bone Miner Res; 2000 Aug; 15(8):1467-76. PubMed ID: 10934645
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.
    Merrell MA, Wakchoure S, Lehenkari PP, Harris KW, Selander KS.
    Eur J Pharmacol; 2007 Sep 10; 570(1-3):27-37. PubMed ID: 17640631
    [Abstract] [Full Text] [Related]

  • 7. Bisphosphonates: the first 40 years.
    Russell RG.
    Bone; 2011 Jul 10; 49(1):2-19. PubMed ID: 21555003
    [Abstract] [Full Text] [Related]

  • 8. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis.
    Wang G, Beier F.
    J Bone Miner Res; 2005 Jun 10; 20(6):1022-31. PubMed ID: 15883643
    [Abstract] [Full Text] [Related]

  • 9. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
    Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ.
    J Pharmacol Exp Ther; 2001 Feb 10; 296(2):235-42. PubMed ID: 11160603
    [Abstract] [Full Text] [Related]

  • 10. Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.
    Thompson K, Rogers MJ.
    J Bone Miner Res; 2004 Feb 10; 19(2):278-88. PubMed ID: 14969398
    [Abstract] [Full Text] [Related]

  • 11. A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.
    Hughes A, Rogers MJ, Idris AI, Crockett JC.
    Calcif Tissue Int; 2007 Nov 10; 81(5):403-13. PubMed ID: 17982704
    [Abstract] [Full Text] [Related]

  • 12. Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells.
    Oades GM, Senaratne SG, Clarke IA, Kirby RS, Colston KW.
    J Urol; 2003 Jul 10; 170(1):246-52. PubMed ID: 12796698
    [Abstract] [Full Text] [Related]

  • 13. [Bisphosphonates: the molecular targets and mechanisms of action].
    Wada S, Kamiya S, Ono K.
    Clin Calcium; 2005 May 10; 15(5):819-24. PubMed ID: 15876745
    [Abstract] [Full Text] [Related]

  • 14. Protein synthesis is required for caspase activation and induction of apoptosis by bisphosphonate drugs.
    Coxon FP, Benford HL, Russell RG, Rogers MJ.
    Mol Pharmacol; 1998 Oct 10; 54(4):631-8. PubMed ID: 9765505
    [Abstract] [Full Text] [Related]

  • 15. Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.
    Luckman SP, Coxon FP, Ebetino FH, Russell RG, Rogers MJ.
    J Bone Miner Res; 1998 Nov 10; 13(11):1668-78. PubMed ID: 9797474
    [Abstract] [Full Text] [Related]

  • 16. Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field.
    Rajnicek AM, Foubister LE, McCaig CD.
    J Cell Sci; 2006 May 01; 119(Pt 9):1723-35. PubMed ID: 16595546
    [Abstract] [Full Text] [Related]

  • 17. Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases.
    Maddala RL, Reddy VN, Rao PV.
    Invest Ophthalmol Vis Sci; 2001 Oct 01; 42(11):2610-5. PubMed ID: 11581207
    [Abstract] [Full Text] [Related]

  • 18. Geranylgeranylated proteins are involved in the regulation of myeloma cell growth.
    van de Donk NW, Lokhorst HM, Nijhuis EH, Kamphuis MM, Bloem AC.
    Clin Cancer Res; 2005 Jan 15; 11(2 Pt 1):429-39. PubMed ID: 15701825
    [Abstract] [Full Text] [Related]

  • 19. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB.
    Murga C, Zohar M, Teramoto H, Gutkind JS.
    Oncogene; 2002 Jan 10; 21(2):207-16. PubMed ID: 11803464
    [Abstract] [Full Text] [Related]

  • 20. Vav transformation requires activation of multiple GTPases and regulation of gene expression.
    Palmby TR, Abe K, Karnoub AE, Der CJ.
    Mol Cancer Res; 2004 Dec 10; 2(12):702-11. PubMed ID: 15634759
    [Abstract] [Full Text] [Related]

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