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225 related items for PubMed ID: 16740276

  • 1. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
    Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB.
    Life Sci; 2006 Sep 05; 79(15):1484-92. PubMed ID: 16740276
    [Abstract] [Full Text] [Related]

  • 2. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors.
    Rodríguez C, Alcudia JF, Martínez-González J, Guadall A, Raposo B, Sánchez-Gómez S, Badimon L.
    Cardiovasc Res; 2009 Aug 01; 83(3):595-603. PubMed ID: 19406911
    [Abstract] [Full Text] [Related]

  • 3. RhoA-mediated, tumor necrosis factor alpha-induced activation of NF-kappaB in rheumatoid synoviocytes: inhibitory effect of simvastatin.
    Xu H, Liu P, Liang L, Danesh FR, Yang X, Ye Y, Zhan Z, Yu X, Peng H, Sun L.
    Arthritis Rheum; 2006 Nov 01; 54(11):3441-51. PubMed ID: 17075836
    [Abstract] [Full Text] [Related]

  • 4. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.
    Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB.
    Circ Res; 2002 Jul 26; 91(2):143-50. PubMed ID: 12142347
    [Abstract] [Full Text] [Related]

  • 5. Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells.
    Nishimoto-Hazuku A, Hirase T, Ide N, Ikeda Y, Node K.
    J Cardiovasc Pharmacol; 2008 Mar 26; 51(3):267-73. PubMed ID: 18356691
    [Abstract] [Full Text] [Related]

  • 6. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
    Lee MH, Cho YS, Han YM.
    Stem Cells; 2007 Jul 26; 25(7):1654-63. PubMed ID: 17464088
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.
    Itoh Y, Kimoto K, Imaizumi M, Nakatsuka K.
    Exp Eye Res; 2007 Mar 26; 84(3):464-72. PubMed ID: 17217948
    [Abstract] [Full Text] [Related]

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  • 9. Statins blunt thrombin-induced down-regulation of endothelial nitric oxide synthase expression in human endothelial cells.
    Eto M, Rathgeb L, Cosentino F, Kozai T, Lüscher TF.
    J Cardiovasc Pharmacol; 2006 May 26; 47(5):663-7. PubMed ID: 16775505
    [Abstract] [Full Text] [Related]

  • 10. Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin.
    Porter KE, Turner NA, O'Regan DJ, Ball SG.
    Cardiovasc Res; 2004 Dec 01; 64(3):507-15. PubMed ID: 15537504
    [Abstract] [Full Text] [Related]

  • 11. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.
    Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H.
    Am J Respir Cell Mol Biol; 2006 Dec 01; 35(6):722-9. PubMed ID: 16858009
    [Abstract] [Full Text] [Related]

  • 12. Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA.
    Porter KE, Turner NA, O'Regan DJ, Balmforth AJ, Ball SG.
    Cardiovasc Res; 2004 Mar 01; 61(4):745-55. PubMed ID: 14985071
    [Abstract] [Full Text] [Related]

  • 13. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis.
    Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB.
    Stem Cell Rev; 2006 Mar 01; 2(2):93-102. PubMed ID: 17237547
    [Abstract] [Full Text] [Related]

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  • 15. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
    Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM.
    J Biol Chem; 2002 May 03; 277(18):15309-16. PubMed ID: 11839765
    [Abstract] [Full Text] [Related]

  • 16. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.
    Yamashita M, Otsuka F, Mukai T, Otani H, Inagaki K, Miyoshi T, Goto J, Yamamura M, Makino H.
    J Endocrinol; 2008 Mar 03; 196(3):601-13. PubMed ID: 18310456
    [Abstract] [Full Text] [Related]

  • 17. Effects of 17beta-estradiol on growth and apoptosis in human vascular endothelial cells: influence of mechanical strain and tumor necrosis factor-alpha.
    Ling S, Zhou L, Li H, Dai A, Liu JP, Komesaroff PA, Sudhir K.
    Steroids; 2006 Sep 03; 71(9):799-808. PubMed ID: 16806337
    [Abstract] [Full Text] [Related]

  • 18. Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line.
    Ghosh PM, Ghosh-Choudhury N, Moyer ML, Mott GE, Thomas CA, Foster BA, Greenberg NM, Kreisberg JI.
    Oncogene; 1999 Jul 15; 18(28):4120-30. PubMed ID: 10435593
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of epidermal growth factor-induced RhoA translocation and invasion of human pancreatic cancer cells by 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors.
    Kusama T, Mukai M, Iwasaki T, Tatsuta M, Matsumoto Y, Akedo H, Nakamura H.
    Cancer Res; 2001 Jun 15; 61(12):4885-91. PubMed ID: 11406567
    [Abstract] [Full Text] [Related]

  • 20. Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent.
    Diamant M, Tushuizen ME, Abid-Hussein MN, Hau CM, Böing AN, Sturk A, Nieuwland R.
    Thromb Haemost; 2008 Sep 15; 100(3):489-97. PubMed ID: 18766267
    [Abstract] [Full Text] [Related]

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