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300 related items for PubMed ID: 1674447

  • 1. A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
    Sharma RC, Assaraf YG, Schimke RT.
    Cancer Res; 1991 Jun 01; 51(11):2949-59. PubMed ID: 1674447
    [Abstract] [Full Text] [Related]

  • 2. Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.
    Assaraf YG, Molina A, Schimke RT.
    J Biol Chem; 1989 Nov 05; 264(31):18326-34. PubMed ID: 2572592
    [Abstract] [Full Text] [Related]

  • 3. Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin.
    Sherwood SW, Assaraf YG, Molina A, Schimke RT.
    Cancer Res; 1990 Aug 15; 50(16):4946-50. PubMed ID: 2143099
    [Abstract] [Full Text] [Related]

  • 4. Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype.
    Assaraf YG, Molina A, Schimke RT.
    J Natl Cancer Inst; 1989 Feb 15; 81(4):290-4. PubMed ID: 2521520
    [Abstract] [Full Text] [Related]

  • 5. Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
    Arkin H, Ohnuma T, Kamen BA, Holland JF, Vallabhajosula S.
    Cancer Res; 1989 Dec 01; 49(23):6556-61. PubMed ID: 2573416
    [Abstract] [Full Text] [Related]

  • 6. Mutations leading to antifolate resistance in Chinese hamster ovary cells after exposure to the alkylating agent ethylmethanesulfonate.
    Fanin R, Banerjee D, Volkenandt M, Waltham M, Li WW, Dicker AP, Schweitzer BI, Bertino JR.
    Mol Pharmacol; 1993 Jul 01; 44(1):13-21. PubMed ID: 8341268
    [Abstract] [Full Text] [Related]

  • 7. Characterization of trimetrexate transport in human lymphoblastoid cells and development of impaired influx as a mechanism of resistance to lipophilic antifolates.
    Fry DW, Besserer JA.
    Cancer Res; 1988 Dec 15; 48(24 Pt 1):6986-91. PubMed ID: 2973370
    [Abstract] [Full Text] [Related]

  • 8. Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
    Assaraf YG, Borgnia MJ.
    Anticancer Drugs; 1993 Jun 15; 4(3):395-406. PubMed ID: 8102912
    [Abstract] [Full Text] [Related]

  • 9. Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
    Assaraf YG, Slotky JI.
    J Biol Chem; 1993 Feb 25; 268(6):4556-66. PubMed ID: 8440739
    [Abstract] [Full Text] [Related]

  • 10. Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts.
    Assaraf YG, Feder JN, Sharma RC, Wright JE, Rosowsky A, Shane B, Schimke RT.
    J Biol Chem; 1992 Mar 25; 267(9):5776-84. PubMed ID: 1372892
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  • 15. Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition.
    Seither RL, Trent DF, Mikulecky DC, Rape TJ, Goldman ID.
    J Biol Chem; 1991 Mar 05; 266(7):4112-8. PubMed ID: 1825652
    [Abstract] [Full Text] [Related]

  • 16. Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
    Li WW, Lin JT, Schweitzer BI, Bertino JR.
    Mol Pharmacol; 1991 Nov 05; 40(5):854-8. PubMed ID: 1719370
    [Abstract] [Full Text] [Related]

  • 17. Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
    Bram E, Ifergan I, Shafran A, Berman B, Jansen G, Assaraf YG.
    Cancer Chemother Pharmacol; 2006 Dec 05; 58(6):826-34. PubMed ID: 16612649
    [Abstract] [Full Text] [Related]

  • 18. Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Cancer Lett; 1995 Jan 06; 88(1):93-9. PubMed ID: 7850779
    [Abstract] [Full Text] [Related]

  • 19. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase.
    Mareya SM, Sorrentino BP, Blakley RL.
    Cancer Gene Ther; 1998 Jan 06; 5(4):225-35. PubMed ID: 9694074
    [Abstract] [Full Text] [Related]

  • 20. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 06; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

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