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465 related items for PubMed ID: 16752916

  • 1. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
    Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C.
    Biochemistry; 2006 Jun 13; 45(23):7277-88. PubMed ID: 16752916
    [Abstract] [Full Text] [Related]

  • 2. Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms.
    Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C.
    Biochemistry; 2007 Jul 17; 46(28):8273-87. PubMed ID: 17590021
    [Abstract] [Full Text] [Related]

  • 3. Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist.
    Xiang Z, Proneth B, Dirain ML, Litherland SA, Haskell-Luevano C.
    Biochemistry; 2010 Jun 08; 49(22):4583-600. PubMed ID: 20462274
    [Abstract] [Full Text] [Related]

  • 4. Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.
    Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.
    J Med Chem; 2004 Apr 22; 47(9):2194-207. PubMed ID: 15084118
    [Abstract] [Full Text] [Related]

  • 5. The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs.
    Klovins J, Haitina T, Fridmanis D, Kilianova Z, Kapa I, Fredriksson R, Gallo-Payet N, Schiöth HB.
    Mol Biol Evol; 2004 Mar 22; 21(3):563-79. PubMed ID: 14694081
    [Abstract] [Full Text] [Related]

  • 6. Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants.
    Haskell-Luevano C, Cone RD, Monck EK, Wan YP.
    Biochemistry; 2001 May 22; 40(20):6164-79. PubMed ID: 11352754
    [Abstract] [Full Text] [Related]

  • 7. Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist.
    Joseph CG, Wang XS, Scott JW, Bauzo RM, Xiang Z, Richards NG, Haskell-Luevano C.
    J Med Chem; 2004 Dec 30; 47(27):6702-10. PubMed ID: 15615519
    [Abstract] [Full Text] [Related]

  • 8. Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism.
    Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C.
    Chem Biol Drug Des; 2006 Mar 30; 67(3):215-29. PubMed ID: 16611215
    [Abstract] [Full Text] [Related]

  • 9. Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.
    Chen M, Celik A, Georgeson KE, Harmon CM, Yang Y.
    Regul Pept; 2006 Sep 11; 136(1-3):40-9. PubMed ID: 16820227
    [Abstract] [Full Text] [Related]

  • 10. Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.
    Wilczynski A, Wilson KR, Scott JW, Edison AS, Haskell-Luevano C.
    J Med Chem; 2005 Apr 21; 48(8):3060-75. PubMed ID: 15828845
    [Abstract] [Full Text] [Related]

  • 11. Substituted NDP-MSH peptides paired with mutant melanocortin-4 receptors demonstrate the role of transmembrane 6 in receptor activation.
    Fleck BA, Ling N, Chen C.
    Biochemistry; 2007 Sep 18; 46(37):10473-83. PubMed ID: 17713970
    [Abstract] [Full Text] [Related]

  • 12. Molecular determination of agouti-related protein binding to human melanocortin-4 receptor.
    Yang Y, Chen M, Lai Y, Gantz I, Yagmurlu A, Georgeson KE, Harmon CM.
    Mol Pharmacol; 2003 Jul 18; 64(1):94-103. PubMed ID: 12815165
    [Abstract] [Full Text] [Related]

  • 13. Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor.
    Fan ZC, Sartin JL, Tao YX.
    J Endocrinol; 2008 Jan 18; 196(1):139-48. PubMed ID: 18180325
    [Abstract] [Full Text] [Related]

  • 14. Molecular mechanism of the intracellular segments of the melanocortin-4 receptor for NDP-MSH signaling.
    Yang Y, Chen M, Loux TJ, Georgeson KE, Harmon CM.
    Biochemistry; 2005 May 10; 44(18):6971-9. PubMed ID: 15865442
    [Abstract] [Full Text] [Related]

  • 15. Overview of endogenous and synthetic melanocortin peptides.
    Wilson KR, Todorovic A, Proneth B, Haskell-Luevano C.
    Cell Mol Biol (Noisy-le-grand); 2006 May 30; 52(2):3-20. PubMed ID: 16914082
    [Abstract] [Full Text] [Related]

  • 16. Constitutive receptor activity series: endogenous inverse agonists and constitutive receptor activity in the melanocortin system.
    Adan RA.
    Trends Pharmacol Sci; 2006 Apr 30; 27(4):183-6. PubMed ID: 16500715
    [Abstract] [Full Text] [Related]

  • 17. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors.
    Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I.
    Biochemistry; 2005 Mar 08; 44(9):3418-31. PubMed ID: 15736952
    [Abstract] [Full Text] [Related]

  • 18. Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist.
    Wilczynski A, Wang XS, Bauzo RM, Xiang Z, Shaw AM, Millard WJ, Richards NG, Edison AS, Haskell-Luevano C.
    J Med Chem; 2004 Nov 04; 47(23):5662-73. PubMed ID: 15509165
    [Abstract] [Full Text] [Related]

  • 19. [Psychiatric disorders and neural mechanisms underlying energy intake and expenditure: a review].
    Kishi T, Horiguchi J.
    Nihon Shinkei Seishin Yakurigaku Zasshi; 2003 Oct 04; 23(5):197-203. PubMed ID: 14653225
    [Abstract] [Full Text] [Related]

  • 20. Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist.
    Frändberg PA, Doufexis M, Kapas S, Chhajlani V.
    Biochem Biophys Res Commun; 2001 Mar 09; 281(4):851-7. PubMed ID: 11237737
    [Abstract] [Full Text] [Related]

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