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499 related items for PubMed ID: 16754782

  • 1. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
    Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ.
    Mol Pharmacol; 2006 Sep; 70(3):977-85. PubMed ID: 16754782
    [Abstract] [Full Text] [Related]

  • 2. A xanthine-based epithelium-dependent airway relaxant KMUP-3 (7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) increases respiratory performance and protects against tumor necrosis factor-alpha-induced tracheal contraction, involving nitric oxide release and expression of cGMP and protein kinase G.
    Lin RJ, Wu BN, Lo YC, An LM, Dai ZK, Lin YT, Tang CS, Chen IJ.
    J Pharmacol Exp Ther; 2006 Feb; 316(2):709-17. PubMed ID: 16234412
    [Abstract] [Full Text] [Related]

  • 3. KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.
    Wu BN, Lin RJ, Lo YC, Shen KP, Wang CC, Lin YT, Chen IJ.
    Br J Pharmacol; 2004 Aug; 142(7):1105-14. PubMed ID: 15237094
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  • 4. Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways.
    Chang YC, Li PC, Chen BC, Chang MS, Wang JL, Chiu WT, Lin CH.
    Cell Signal; 2006 Aug; 18(8):1235-43. PubMed ID: 16289764
    [Abstract] [Full Text] [Related]

  • 5. Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.
    Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C.
    Circ Res; 2003 Sep 05; 93(5):406-13. PubMed ID: 12919948
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  • 6. KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.
    Hsu YY, Liu CM, Tsai HH, Jong YJ, Chen IJ, Lo YC.
    Toxicology; 2010 Jan 31; 268(1-2):46-54. PubMed ID: 19962417
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  • 8. TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling.
    Hsiao HY, Mak OT, Yang CS, Liu YP, Fang KM, Tzeng SF.
    Glia; 2007 Jan 15; 55(2):214-23. PubMed ID: 17091492
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  • 10. Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.
    Tunctan B, Korkmaz B, Sari AN, Kacan M, Unsal D, Serin MS, Buharalioglu CK, Sahan-Firat S, Cuez T, Schunck WH, Manthati VL, Falck JR, Malik KU.
    Nitric Oxide; 2013 Sep 01; 33():18-41. PubMed ID: 23684565
    [Abstract] [Full Text] [Related]

  • 11. Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
    Liu CP, Dai ZK, Huang CH, Yeh JL, Wu BN, Wu JR, Chen IJ.
    Kaohsiung J Med Sci; 2014 Jun 01; 30(6):267-78. PubMed ID: 24835346
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  • 12. Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro.
    Fischer BM, Rochelle LG, Voynow JA, Akley NJ, Adler KB.
    Am J Respir Cell Mol Biol; 1999 Mar 01; 20(3):413-22. PubMed ID: 10030839
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  • 13. The effect of nitric oxide on cytokine-induced release of PGE2 by human cultured astroglial cells.
    Mollace V, Colasanti M, Muscoli C, Lauro GM, Iannone M, Rotiroti D, Nistico G.
    Br J Pharmacol; 1998 Jun 01; 124(4):742-6. PubMed ID: 9690866
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  • 14. Phosphodiesterase inhibitor KMUP-3 displays cardioprotection via protein kinase G and increases cardiac output via G-protein-coupled receptor agonist activity and Ca(2+) sensitization.
    Liu CP, Yeh JL, Liou SF, Wu BN, Chen IJ.
    Kaohsiung J Med Sci; 2016 Feb 01; 32(2):55-67. PubMed ID: 26944323
    [Abstract] [Full Text] [Related]

  • 15. Nitric oxide-mediated regulation of connexin43 expression and gap junctional intercellular communication in mesangial cells.
    Yao J, Hiramatsu N, Zhu Y, Morioka T, Takeda M, Oite T, Kitamura M.
    J Am Soc Nephrol; 2005 Jan 01; 16(1):58-67. PubMed ID: 15537869
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  • 18. Aortic smooth muscle relaxants KMUP-3 and KMUP-4, two nitrophenylpiperazine derivatives of xanthine, display cGMP-enhancing activity: roles of endothelium, phosphodiesterase, and K+ channel.
    Wu BN, Chen IC, Lin RJ, Chiu CC, An LM, Chen IJ.
    J Cardiovasc Pharmacol; 2005 Nov 01; 46(5):600-8. PubMed ID: 16220066
    [Abstract] [Full Text] [Related]

  • 19. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
    Chung HH, Dai ZK, Wu BN, Yeh JL, Chai CY, Chu KS, Liu CP, Chen IJ.
    Br J Pharmacol; 2010 Jun 01; 160(4):971-86. PubMed ID: 20590592
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  • 20. Complementary roles of tumor necrosis factor alpha and interferon gamma in inducible microglial nitric oxide generation.
    Mir M, Tolosa L, Asensio VJ, Lladó J, Olmos G.
    J Neuroimmunol; 2008 Nov 15; 204(1-2):101-9. PubMed ID: 18703234
    [Abstract] [Full Text] [Related]


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