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Journal Abstract Search
139 related items for PubMed ID: 16759001
1. [The pharmacokinetics and pharmacodynamics of recombinant hirudin-2 nasal spray]. Zhang YJ, Zhang Q, Hou JL, Wang XL, Chen MX. Yao Xue Xue Bao; 2006 Mar; 41(3):268-71. PubMed ID: 16759001 [Abstract] [Full Text] [Related]
2. Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes. Liu Y, Lu WL, Zhang X, Wang XQ, Zhang H, Zhang Q. Peptides; 2005 Mar; 26(3):423-30. PubMed ID: 15652649 [Abstract] [Full Text] [Related]
3. [Studies on preparation of recombinant hirudin-2 liposome and its pharmacokinetics by nasal delivery in rats]. Zhang YJ, Wang XL, Wu JM, Cheng MX. Zhongguo Zhong Yao Za Zhi; 2007 May; 32(9):801-4. PubMed ID: 17639978 [Abstract] [Full Text] [Related]
4. Permeation-enhancing effects of chitosan formulations on recombinant hirudin-2 by nasal delivery in vitro and in vivo. Zhang YJ, Ma CH, Lu WL, Zhang X, Wang XL, Sun JN, Zhang Q. Acta Pharmacol Sin; 2005 Nov; 26(11):1402-8. PubMed ID: 16225765 [Abstract] [Full Text] [Related]
5. Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes. Meng M, Liu Y, Wang YB, Wang JC, Zhang H, Wang XQ, Zhang X, Lu WL, Zhang Q. J Control Release; 2008 Jun 04; 128(2):113-9. PubMed ID: 18423766 [Abstract] [Full Text] [Related]
6. Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats. Freund M, Cazenave JP, Courtney M, Degryse E, Roitsch C, Bernat A, Delebassée D, Defreyn G, Maffrand JP. Thromb Haemost; 1990 Apr 12; 63(2):187-92. PubMed ID: 2363120 [Abstract] [Full Text] [Related]
7. Studies on the pharmacokinetics and pharmacodynamics of recombinant hirudin (rHV2-Lys 47) after intravenous and subcutaneous administration in dogs. Iyer L, Koza M, Iqbal O, Calabria R, Fareed J. Thromb Res; 1993 Feb 01; 69(3):259-69. PubMed ID: 8475476 [Abstract] [Full Text] [Related]
8. Nasal recombinant hirudin-2 delivery: absorption and its mechanism in vivo and in vitro studies. Zhang Y, Zhang Q, Sun Y, Sun J, Wang X, Chen M. Biol Pharm Bull; 2005 Dec 01; 28(12):2263-7. PubMed ID: 16327162 [Abstract] [Full Text] [Related]
9. [Degradation of recombinant hirudin-2 in nasal mucosa of rabbits in vitro]. Zhang YJ, Wu JM, Zhang Q, Chen MX, Sun WJ. Yao Xue Xue Bao; 2006 Nov 01; 41(11):1099-103. PubMed ID: 17262955 [Abstract] [Full Text] [Related]
10. Investigation on recombinant hirudin via oral route. Cen X, Ni J, Tan T, Liu X, Li C, Chen J, Huang Y, Zhu S, Bi Q. Peptides; 2006 Apr 01; 27(4):836-40. PubMed ID: 16469415 [Abstract] [Full Text] [Related]
11. Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization. Liu Y, Lu WL, Wang JC, Zhang X, Zhang H, Wang XQ, Zhou TY, Zhang Q. J Control Release; 2007 Feb 26; 117(3):387-95. PubMed ID: 17207884 [Abstract] [Full Text] [Related]
12. [Preparation of freeze-dried powder of recombinate hirudin-2 nanoparticle for nasal delivery and permeability through nasal membrane in vitro]. Chen MX, Zhang JB, Yu JP, Ye J, Wei BH, Zhang YJ. Zhong Yao Cai; 2013 Jun 26; 36(6):999-1002. PubMed ID: 24380289 [Abstract] [Full Text] [Related]
14. [Absorption of recombinant hirudin in rats GI tract]. Yan XY, Zhang XN, Zhang Q. Yao Xue Xue Bao; 2004 Jan 26; 39(1):77-80. PubMed ID: 15127588 [Abstract] [Full Text] [Related]
15. [Promoting mechanism of enhancers and transport pathway of large hydrophilic molecular across nasal epithelium studied by ESR and CLSM technologies]. Zhang YJ, Zhang Q, Yang J, Sun MJ, Wang XL, Chen MX, Wang Q, Jiang H. Yao Xue Xue Bao; 2007 Nov 26; 42(11):1195-200. PubMed ID: 18300478 [Abstract] [Full Text] [Related]