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168 related items for PubMed ID: 1676635

  • 1. Inhibition and activation of acetaminophen reactive metabolite formation by caffeine. Roles of cytochromes P-450IA1 and IIIA2.
    Lee CA, Thummel KE, Kalhorn TF, Nelson SD, Slattery JT.
    Drug Metab Dispos; 1991; 19(2):348-53. PubMed ID: 1676635
    [Abstract] [Full Text] [Related]

  • 2. Activation of acetaminophen-reactive metabolite formation by methylxanthines and known cytochrome P-450 activators.
    Lee CA, Thummel KE, Kalhorn TF, Nelson SD, Slattery JT.
    Drug Metab Dispos; 1991; 19(5):966-71. PubMed ID: 1686244
    [Abstract] [Full Text] [Related]

  • 3. Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation.
    Lee CA, Lillibridge JH, Nelson SD, Slattery JT.
    J Pharmacol Exp Ther; 1996 Apr; 277(1):287-91. PubMed ID: 8613932
    [Abstract] [Full Text] [Related]

  • 4. Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
    Jaw S, Jeffery EH.
    Biochem Pharmacol; 1993 Aug 03; 46(3):493-501. PubMed ID: 8347173
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes.
    Lee CA, Manyike PT, Thummel KE, Nelson SD, Slattery JT.
    Drug Metab Dispos; 1997 Oct 03; 25(10):1150-6. PubMed ID: 9321518
    [Abstract] [Full Text] [Related]

  • 6. Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine.
    Tan SC, New LS, Chan EC.
    Toxicol Lett; 2008 Aug 28; 180(3):174-81. PubMed ID: 18588957
    [Abstract] [Full Text] [Related]

  • 7. Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
    Kalhorn TF, Lee CA, Slattery JT, Nelson SD.
    J Pharmacol Exp Ther; 1990 Jan 28; 252(1):112-6. PubMed ID: 2299585
    [Abstract] [Full Text] [Related]

  • 8. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
    Moffit JS, Aleksunes LM, Kardas MJ, Slitt AL, Klaassen CD, Manautou JE.
    Toxicology; 2007 Feb 12; 230(2-3):197-206. PubMed ID: 17188792
    [Abstract] [Full Text] [Related]

  • 9. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
    Dahlin DC, Miwa GT, Lu AY, Nelson SD.
    Proc Natl Acad Sci U S A; 1984 Mar 12; 81(5):1327-31. PubMed ID: 6424115
    [Abstract] [Full Text] [Related]

  • 10. Reduction of toxic metabolite formation of acetaminophen.
    Hazai E, Vereczkey L, Monostory K.
    Biochem Biophys Res Commun; 2002 Mar 08; 291(4):1089-94. PubMed ID: 11866476
    [Abstract] [Full Text] [Related]

  • 11. Activation of acetaminophen oxidation in rat liver microsomes by caffeine.
    Nouchi T, Lasker JM, Lieber CS.
    Toxicol Lett; 1986 Mar 08; 32(1-2):1-8. PubMed ID: 3738921
    [Abstract] [Full Text] [Related]

  • 12. An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
    Park JH, Seo KS, Tadi S, Ahn BH, Lee JU, Heo JY, Han J, Song MS, Kim SH, Yim YH, Choi HS, Shong M, Kweon G.
    Antioxid Redox Signal; 2013 May 10; 18(14):1713-22. PubMed ID: 23121402
    [Abstract] [Full Text] [Related]

  • 13. Acetaminophen reactive intermediates target hepatic thioredoxin reductase.
    Jan YH, Heck DE, Dragomir AC, Gardner CR, Laskin DL, Laskin JD.
    Chem Res Toxicol; 2014 May 19; 27(5):882-94. PubMed ID: 24661219
    [Abstract] [Full Text] [Related]

  • 14. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.
    Thummel KE, Lee CA, Kunze KL, Nelson SD, Slattery JT.
    Biochem Pharmacol; 1993 Apr 22; 45(8):1563-9. PubMed ID: 8387297
    [Abstract] [Full Text] [Related]

  • 15. Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.
    Santoh M, Sanoh S, Ohtsuki Y, Ejiri Y, Kotake Y, Ohta S.
    Biochem Biophys Res Commun; 2017 May 06; 486(3):639-644. PubMed ID: 28341123
    [Abstract] [Full Text] [Related]

  • 16. Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice.
    Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y.
    J Toxicol Sci; 2015 Dec 06; 40(6):837-41. PubMed ID: 26558465
    [Abstract] [Full Text] [Related]

  • 17. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.
    Manyike PT, Kharasch ED, Kalhorn TF, Slattery JT.
    Clin Pharmacol Ther; 2000 Mar 06; 67(3):275-82. PubMed ID: 10741631
    [Abstract] [Full Text] [Related]

  • 18. Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.
    Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD.
    Drug Metab Dispos; 2000 Dec 06; 28(12):1397-400. PubMed ID: 11095574
    [Abstract] [Full Text] [Related]

  • 19. Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease.
    Michaut A, Moreau C, Robin MA, Fromenty B.
    Liver Int; 2014 Aug 06; 34(7):e171-9. PubMed ID: 24575957
    [Abstract] [Full Text] [Related]

  • 20. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.
    Laine JE, Auriola S, Pasanen M, Juvonen RO.
    Xenobiotica; 2009 Jan 06; 39(1):11-21. PubMed ID: 19219744
    [Abstract] [Full Text] [Related]

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