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168 related items for PubMed ID: 1676635

  • 41. A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine and glutathione.
    Klopčič I, Poberžnik M, Mavri J, Dolenc MS.
    Chem Biol Interact; 2015 Dec 05; 242():407-14. PubMed ID: 26551927
    [Abstract] [Full Text] [Related]

  • 42. N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.
    Bender RP, Lindsey RH, Burden DA, Osheroff N.
    Biochemistry; 2004 Mar 30; 43(12):3731-9. PubMed ID: 15035644
    [Abstract] [Full Text] [Related]

  • 43. N-acetyl-p-benzoquinone imine-induced protein thiol modification in isolated rat hepatocytes.
    Weis M, Morgenstern R, Cotgreave IA, Nelson SD, Moldéus P.
    Biochem Pharmacol; 1992 Apr 01; 43(7):1493-505. PubMed ID: 1567474
    [Abstract] [Full Text] [Related]

  • 44. Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.
    Qian W, Amin RH, Shichi H.
    J Ocul Pharmacol Ther; 1999 Dec 01; 15(6):537-45. PubMed ID: 10609776
    [Abstract] [Full Text] [Related]

  • 45. The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
    van de Straat R, de Vries J, Debets AJ, Vermeulen NP.
    Biochem Pharmacol; 1987 Jul 01; 36(13):2065-70. PubMed ID: 3606627
    [Abstract] [Full Text] [Related]

  • 46. Comparative cytotoxic effects of N-acetyl-p-benzoquinone imine and two dimethylated analogues.
    Rundgren M, Porubek DJ, Harvison PJ, Cotgreave IA, Moldéus P, Nelson SD.
    Mol Pharmacol; 1988 Oct 01; 34(4):566-72. PubMed ID: 3173335
    [Abstract] [Full Text] [Related]

  • 47. Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.
    Harvison PJ, Guengerich FP, Rashed MS, Nelson SD.
    Chem Res Toxicol; 1988 Oct 01; 1(1):47-52. PubMed ID: 2979711
    [Abstract] [Full Text] [Related]

  • 48. Novel approach for evaluating pharmaceuticals toxicity using Daphnia model: analysis of the mode of cytochrome P450-generated metabolite action after acetaminophen exposure.
    Kim RO, Jo MA, Song J, Kim IC, Yoon S, Kim WK.
    Aquat Toxicol; 2018 Mar 01; 196():35-42. PubMed ID: 29328974
    [Abstract] [Full Text] [Related]

  • 49. Formation of 4-aminophenoxyl free radical from the acetaminophen metabolite N-acetyl-p-benzoquinone imine.
    Fischer V, West PR, Nelson SD, Harvison PJ, Mason RP.
    J Biol Chem; 1985 Sep 25; 260(21):11446-50. PubMed ID: 2995335
    [Abstract] [Full Text] [Related]

  • 50. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide.
    Dietze EC, Schäfer A, Omichinski JG, Nelson SD.
    Chem Res Toxicol; 1997 Oct 25; 10(10):1097-103. PubMed ID: 9348431
    [Abstract] [Full Text] [Related]

  • 51. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.
    Thummel KE, Slattery JT, Ro H, Chien JY, Nelson SD, Lown KE, Watkins PB.
    Clin Pharmacol Ther; 2000 Jun 25; 67(6):591-9. PubMed ID: 10872641
    [Abstract] [Full Text] [Related]

  • 52. The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen.
    Harman AW, Kyle ME, Serroni A, Farber JL.
    Biochem Pharmacol; 1991 Apr 15; 41(8):1111-7. PubMed ID: 2009090
    [Abstract] [Full Text] [Related]

  • 53. In-source formation of N-acetyl-p-benzoquinone imine (NAPQI), the putatively toxic acetaminophen (paracetamol) metabolite, after derivatization with pentafluorobenzyl bromide and GC-ECNICI-MS analysis.
    Tsikas D, Trettin A, Zörner AA, Gutzki FM.
    J Chromatogr B Analyt Technol Biomed Life Sci; 2011 May 15; 879(17-18):1476-84. PubMed ID: 21353649
    [Abstract] [Full Text] [Related]

  • 54. Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice.
    Lin MC, Wang EJ, Patten C, Lee MJ, Xiao F, Reuhl KR, Yang CS.
    J Biochem Toxicol; 1996 May 15; 11(1):11-20. PubMed ID: 8806047
    [Abstract] [Full Text] [Related]

  • 55. Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.
    Prot JM, Bunescu A, Elena-Herrmann B, Aninat C, Snouber LC, Griscom L, Razan F, Bois FY, Legallais C, Brochot C, Corlu A, Dumas ME, Leclerc E.
    Toxicol Appl Pharmacol; 2012 Mar 15; 259(3):270-80. PubMed ID: 22230336
    [Abstract] [Full Text] [Related]

  • 56. Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
    Raghavendran HB, Sathivel A, Devaki T.
    World J Gastroenterol; 2006 Jun 28; 12(24):3829-34. PubMed ID: 16804966
    [Abstract] [Full Text] [Related]

  • 57. Investigation of acetaminophen toxicity in HepG2/C3a microscale cultures using a system biology model of glutathione depletion.
    Leclerc E, Hamon J, Claude I, Jellali R, Naudot M, Bois F.
    Cell Biol Toxicol; 2015 Jun 28; 31(3):173-85. PubMed ID: 25956491
    [Abstract] [Full Text] [Related]

  • 58. Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes.
    Van De Straat R, De Vries J, Kulkens T, Debets AJ, Vermeulen NP.
    Biochem Pharmacol; 1986 Nov 01; 35(21):3693-9. PubMed ID: 3778500
    [Abstract] [Full Text] [Related]

  • 59. Reduction of 3'-azido-2',3'-dideoxynucleosides to their 3'-amino metabolite is mediated by cytochrome P-450 and NADPH-cytochrome P-450 reductase in rat liver microsomes.
    Cretton EM, Sommadossi JP.
    Drug Metab Dispos; 1993 Nov 01; 21(5):946-50. PubMed ID: 7902260
    [Abstract] [Full Text] [Related]

  • 60. Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos.
    Weigt S, Huebler N, Braunbeck T, von Landenberg F, Broschard TH.
    Toxicology; 2010 Sep 10; 275(1-3):36-49. PubMed ID: 20566340
    [Abstract] [Full Text] [Related]

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