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2723 related items for PubMed ID: 16778202

  • 1. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway.
    Carroll VA, Ashcroft M.
    Cancer Res; 2006 Jun 15; 66(12):6264-70. PubMed ID: 16778202
    [Abstract] [Full Text] [Related]

  • 2. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.
    Oncogene; 2000 Nov 16; 19(48):5435-43. PubMed ID: 11114720
    [Abstract] [Full Text] [Related]

  • 3. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C, Moore JW, Robertson N, Harris AL.
    Cancer Res; 2001 Oct 01; 61(19):7349-55. PubMed ID: 11585776
    [Abstract] [Full Text] [Related]

  • 4. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
    Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M.
    Carcinogenesis; 2007 Mar 01; 28(3):529-36. PubMed ID: 16920734
    [Abstract] [Full Text] [Related]

  • 5. The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1α and -2α in sporadic clear cell renal carcinoma.
    Gong K, Zhang N, Zhang K, Na Y.
    Int J Mol Med; 2010 Dec 01; 26(6):907-12. PubMed ID: 21042786
    [Abstract] [Full Text] [Related]

  • 6. Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma.
    Osada R, Horiuchi A, Kikuchi N, Yoshida J, Hayashi A, Ota M, Katsuyama Y, Melillo G, Konishi I.
    Hum Pathol; 2007 Sep 01; 38(9):1310-20. PubMed ID: 17555795
    [Abstract] [Full Text] [Related]

  • 7. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
    Wiesener MS, Münchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jürgensen JS, Gruber G, Maxwell PH, Löning SA, Frei U, Maher ER, Gröne HJ, Eckardt KU.
    Cancer Res; 2001 Jul 01; 61(13):5215-22. PubMed ID: 11431362
    [Abstract] [Full Text] [Related]

  • 8. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
    Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM.
    BMC Cancer; 2012 Jul 17; 12():293. PubMed ID: 22804960
    [Abstract] [Full Text] [Related]

  • 9. Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells.
    Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ.
    Cancer Res; 2005 Jun 01; 65(11):4775-81. PubMed ID: 15930297
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.
    Schödel J, Grampp S, Maher ER, Moch H, Ratcliffe PJ, Russo P, Mole DR.
    Eur Urol; 2016 Apr 01; 69(4):646-657. PubMed ID: 26298207
    [Abstract] [Full Text] [Related]

  • 11. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
    Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ.
    Mol Cell Biol; 2005 Jul 01; 25(13):5675-86. PubMed ID: 15964822
    [Abstract] [Full Text] [Related]

  • 12. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
    Liu MY, Poellinger L, Walker CL.
    Cancer Res; 2003 May 15; 63(10):2675-80. PubMed ID: 12750296
    [Abstract] [Full Text] [Related]

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  • 15. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
    Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S.
    Cancer Res; 2005 Jun 15; 65(12):5221-30. PubMed ID: 15958567
    [Abstract] [Full Text] [Related]

  • 16. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
    Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL.
    Cancer Res; 2003 Oct 01; 63(19):6130-4. PubMed ID: 14559790
    [Abstract] [Full Text] [Related]

  • 17. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
    Petrella BL, Brinckerhoff CE.
    Cancer Biol Ther; 2009 Jul 01; 8(14):1389-401. PubMed ID: 19483472
    [Abstract] [Full Text] [Related]

  • 18. Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.
    Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, Barod R, Grillari J, Grillari-Voglauer R, Maxwell PH, Esteban MA.
    Oncogene; 2012 Feb 23; 31(8):1065-72. PubMed ID: 21841824
    [Abstract] [Full Text] [Related]

  • 19. Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.
    Kim CM, Vocke C, Torres-Cabala C, Yang Y, Schmidt L, Walther M, Linehan WM.
    J Urol; 2006 May 23; 175(5):1908-14. PubMed ID: 16600797
    [Abstract] [Full Text] [Related]

  • 20. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
    Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL.
    Cancer Res; 2006 Mar 01; 66(5):2725-31. PubMed ID: 16510593
    [Abstract] [Full Text] [Related]

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