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Journal Abstract Search

189 related items for PubMed ID: 16784221

  • 1. Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.
    Poelarends GJ, Almrud JJ, Serrano H, Darty JE, Johnson WH, Hackert ML, Whitman CP.
    Biochemistry; 2006 Jun 27; 45(25):7700-8. PubMed ID: 16784221
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  • 2. The roles of active-site residues in the catalytic mechanism of trans-3-chloroacrylic acid dehalogenase: a kinetic, NMR, and mutational analysis.
    Azurmendi HF, Wang SC, Massiah MA, Poelarends GJ, Whitman CP, Mildvan AS.
    Biochemistry; 2004 Apr 13; 43(14):4082-91. PubMed ID: 15065850
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  • 3. Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases.
    Poelarends GJ, Serrano H, Person MD, Johnson WH, Murzin AG, Whitman CP.
    Biochemistry; 2004 Jan 27; 43(3):759-72. PubMed ID: 14730981
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  • 4. Systematic screening for catalytic promiscuity in 4-oxalocrotonate tautomerase: enamine formation and aldolase activity.
    Zandvoort E, Baas BJ, Quax WJ, Poelarends GJ.
    Chembiochem; 2011 Mar 07; 12(4):602-9. PubMed ID: 21290551
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  • 5. Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase.
    Harris TK, Czerwinski RM, Johnson WH, Legler PM, Abeygunawardana C, Massiah MA, Stivers JT, Whitman CP, Mildvan AS.
    Biochemistry; 1999 Sep 21; 38(38):12343-57. PubMed ID: 10493802
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  • 8. The 4-oxalocrotonate tautomerase- and YwhB-catalyzed hydration of 3E-haloacrylates: implications for the evolution of new enzymatic activities.
    Wang SC, Johnson WH, Whitman CP.
    J Am Chem Soc; 2003 Nov 26; 125(47):14282-3. PubMed ID: 14624569
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  • 13. The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily.
    Poelarends GJ, Veetil VP, Whitman CP.
    Cell Mol Life Sci; 2008 Nov 26; 65(22):3606-18. PubMed ID: 18695941
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  • 14. The structural basis for the perturbed pKa of the catalytic base in 4-oxalocrotonate tautomerase: kinetic and structural effects of mutations of Phe-50.
    Czerwinski RM, Harris TK, Massiah MA, Mildvan AS, Whitman CP.
    Biochemistry; 2001 Feb 20; 40(7):1984-95. PubMed ID: 11329265
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  • 15. Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction?
    Poelarends GJ, Johnson WH, Serrano H, Whitman CP.
    Biochemistry; 2007 Aug 21; 46(33):9596-604. PubMed ID: 17661448
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  • 16. Reactions of trans-3-chloroacrylic acid dehalogenase with acetylene substrates: consequences of and evidence for a hydration reaction.
    Wang SC, Person MD, Johnson WH, Whitman CP.
    Biochemistry; 2003 Jul 29; 42(29):8762-73. PubMed ID: 12873137
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  • 17. Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily.
    LeVieux JA, Baas BJ, Kaoud TS, Davidson R, Babbitt PC, Zhang YJ, Whitman CP.
    Arch Biochem Biophys; 2017 Dec 15; 636():50-56. PubMed ID: 29111295
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  • 18. The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily.
    de Jong RM, Brugman W, Poelarends GJ, Whitman CP, Dijkstra BW.
    J Biol Chem; 2004 Mar 19; 279(12):11546-52. PubMed ID: 14701869
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  • 19. Reactions of 4-oxalocrotonate tautomerase and YwhB with 3-halopropiolates: analysis and implications.
    Wang SC, Johnson WH, Czerwinski RM, Whitman CP.
    Biochemistry; 2004 Jan 27; 43(3):748-58. PubMed ID: 14730980
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