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124 related items for PubMed ID: 16787363

  • 1. Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
    Purnell B, Lingerfelt B, Scott A, Townes H, Summerville K, Hudson S, Kiakos K, Hartley JA, Lee M.
    Med Chem; 2006 Mar; 2(2):139-46. PubMed ID: 16787363
    [Abstract] [Full Text] [Related]

  • 2. Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
    Howard TT, Lingerfelt BM, Purnell BL, Scott AE, Price CA, Townes HM, McNulty L, Handl HL, Summerville K, Hudson SJ, Bowen JP, Kiakos K, Hartley JA, Lee M.
    Bioorg Med Chem; 2002 Sep; 10(9):2941-52. PubMed ID: 12110316
    [Abstract] [Full Text] [Related]

  • 3. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.
    Patil PC, Satam V, Lee M.
    Anticancer Agents Med Chem; 2015 Sep; 15(5):616-30. PubMed ID: 25511515
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
    Baraldi PG, Balboni G, Pavani MG, Spalluto G, Tabrizi MA, Clercq ED, Balzarini J, Bando T, Sugiyama H, Romagnoli R.
    J Med Chem; 2001 Aug 02; 44(16):2536-43. PubMed ID: 11472207
    [Abstract] [Full Text] [Related]

  • 5. A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
    Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M.
    Bioorg Med Chem; 2004 Dec 01; 12(23):6221-36. PubMed ID: 15519165
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
    Lajiness JP, Robertson WM, Dunwiddie I, Broward MA, Vielhauer GA, Weir SJ, Boger DL.
    J Med Chem; 2010 Nov 11; 53(21):7731-8. PubMed ID: 20942408
    [Abstract] [Full Text] [Related]

  • 7. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
    Boger DL, Searcey M, Tse WC, Jin Q.
    Bioorg Med Chem Lett; 2000 Mar 06; 10(5):495-8. PubMed ID: 10743956
    [Abstract] [Full Text] [Related]

  • 8. Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity.
    Milbank JB, Tercel M, Atwell GJ, Wilson WR, Hogg A, Denny WA.
    J Med Chem; 1999 Feb 25; 42(4):649-58. PubMed ID: 10052972
    [Abstract] [Full Text] [Related]

  • 9. Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
    Pati H, Howard T, Townes H, Lingerfelt B, McNulty L, Lee M.
    Molecules; 2004 Feb 28; 9(3):125-33. PubMed ID: 18007417
    [Abstract] [Full Text] [Related]

  • 10. A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
    Sato A, McNulty L, Cox K, Kim S, Scott A, Daniell K, Summerville K, Price C, Hudson S, Kiakos K, Hartley JA, Asao T, Lee M.
    J Med Chem; 2005 Jun 02; 48(11):3903-18. PubMed ID: 15916443
    [Abstract] [Full Text] [Related]

  • 11. A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
    Toth JL, Trzupek JD, Flores LV, Kiakos K, Hartley JA, Pennington WT, Lee M.
    Med Chem; 2005 Jan 02; 1(1):13-9. PubMed ID: 16789881
    [Abstract] [Full Text] [Related]

  • 12. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA.
    Gieseg MA, Matejovic J, Denny WA.
    Anticancer Drug Des; 1999 Feb 02; 14(1):77-84. PubMed ID: 10363030
    [Abstract] [Full Text] [Related]

  • 13. DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
    Kiakos K, Sato A, Asao T, McHugh PJ, Lee M, Hartley JA.
    Mol Cancer Ther; 2007 Oct 02; 6(10):2708-18. PubMed ID: 17938264
    [Abstract] [Full Text] [Related]

  • 14. 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
    Atwell GJ, Milbank JJ, Wilson WR, Hogg A, Denny WA.
    J Med Chem; 1999 Aug 26; 42(17):3400-11. PubMed ID: 10464026
    [Abstract] [Full Text] [Related]

  • 15. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
    Boger DL, Hughes TV, Hedrick MP.
    J Org Chem; 2001 Apr 06; 66(7):2207-16. PubMed ID: 11281757
    [Abstract] [Full Text] [Related]

  • 16. DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
    Purnell B, Sato A, O'kelley A, Price C, Summerville K, Hudson S, O'hare C, Kiakos K, Asao T, Lee M, Hartley JA.
    Bioorg Med Chem Lett; 2006 Nov 01; 16(21):5677-81. PubMed ID: 16919946
    [Abstract] [Full Text] [Related]

  • 17. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
    Tichenor MS, Trzupek JD, Kastrinsky DB, Shiga F, Hwang I, Boger DL.
    J Am Chem Soc; 2006 Dec 13; 128(49):15683-96. PubMed ID: 17147378
    [Abstract] [Full Text] [Related]

  • 18. Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3'-arylenebisacryloyl group as a linker.
    Fukuda Y, Seto S, Furuta H, Ebisu H, Oomori Y, Terashima S.
    J Med Chem; 2001 Apr 26; 44(9):1396-406. PubMed ID: 11311062
    [Abstract] [Full Text] [Related]

  • 19. The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups.
    Fukuda Y, Furuta H, Kusama Y, Ebisu H, Oomori Y, Terashima S.
    Bioorg Med Chem Lett; 1998 Jun 02; 8(11):1387-90. PubMed ID: 9871771
    [Abstract] [Full Text] [Related]

  • 20. Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate.
    Park S, Bando T, Shinohara K, Nishijima S, Sugiyama H.
    Bioconjug Chem; 2011 Feb 16; 22(2):120-4. PubMed ID: 21192678
    [Abstract] [Full Text] [Related]

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