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Journal Abstract Search

246 related items for PubMed ID: 16803899

  • 1. Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.
    Thomson JM, Distler AM, Prati F, Bonomo RA.
    J Biol Chem; 2006 Sep 08; 281(36):26734-44. PubMed ID: 16803899
    [Abstract] [Full Text] [Related]

  • 2. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 3. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
    [Abstract] [Full Text] [Related]

  • 4. Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
    Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA.
    J Biol Chem; 2005 Oct 21; 280(42):35528-36. PubMed ID: 15987690
    [Abstract] [Full Text] [Related]

  • 5. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 6. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug 26; 56(8):4428-38. PubMed ID: 22687511
    [Abstract] [Full Text] [Related]

  • 7. OHIO-1 beta-lactamase mutants: the Arg244Ser mutant and resistance to beta-lactams and beta-lactamase inhibitors.
    Lin S, Thomas M, Mark S, Anderson V, Bonomo RA.
    Biochim Biophys Acta; 1999 Jun 15; 1432(1):125-36. PubMed ID: 10366735
    [Abstract] [Full Text] [Related]

  • 8. Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
    Manageiro V, Ferreira E, Cougnoux A, Albuquerque L, Caniça M, Bonnet R.
    Antimicrob Agents Chemother; 2012 Feb 15; 56(2):1042-6. PubMed ID: 22083476
    [Abstract] [Full Text] [Related]

  • 9. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 15; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 10. Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.
    Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.
    mBio; 2017 Oct 31; 8(5):. PubMed ID: 29089425
    [Abstract] [Full Text] [Related]

  • 11. Avibactam and inhibitor-resistant SHV β-lactamases.
    Winkler ML, Papp-Wallace KM, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 31; 59(7):3700-9. PubMed ID: 25691639
    [Abstract] [Full Text] [Related]

  • 12. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 31; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 13. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.
    Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA.
    J Med Chem; 2013 Feb 14; 56(3):1084-97. PubMed ID: 23252553
    [Abstract] [Full Text] [Related]

  • 14. SHV-type beta-lactamases.
    Tzouvelekis LS, Bonomo RA.
    Curr Pharm Des; 1999 Nov 14; 5(11):847-64. PubMed ID: 10539992
    [Abstract] [Full Text] [Related]

  • 15. Mutagenesis of amino acid residues in the SHV-1 beta-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance.
    Hujer AM, Hujer KM, Bonomo RA.
    Biochim Biophys Acta; 2001 May 05; 1547(1):37-50. PubMed ID: 11343789
    [Abstract] [Full Text] [Related]

  • 16. Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
    Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR.
    Biochemistry; 2007 Jul 24; 46(29):8689-99. PubMed ID: 17595114
    [Abstract] [Full Text] [Related]

  • 17. Amino acid substitutions causing inhibitor resistance in TEM beta-lactamases compromise the extended-spectrum phenotype in SHV extended-spectrum beta-lactamases.
    Randegger CC, Hächler H.
    J Antimicrob Chemother; 2001 May 24; 47(5):547-54. PubMed ID: 11328764
    [Abstract] [Full Text] [Related]

  • 18. Homology modeling and virtual screening of inhibitors against TEM- and SHV-type-resistant mutants: A multilayer filtering approach.
    Baig MH, Balaramnavar VM, Wadhwa G, Khan AU.
    Biotechnol Appl Biochem; 2015 May 24; 62(5):669-80. PubMed ID: 25779642
    [Abstract] [Full Text] [Related]

  • 19. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov 24; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

  • 20. Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.
    Stapleton PD, Shannon KP, French GL.
    Antimicrob Agents Chemother; 1999 Aug 24; 43(8):1881-7. PubMed ID: 10428907
    [Abstract] [Full Text] [Related]

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