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431 related items for PubMed ID: 16843668

  • 1. New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides.
    Amin KM, Ismail MM, Noaman E, Soliman DH, Ammar YA.
    Bioorg Med Chem; 2006 Oct 15; 14(20):6917-23. PubMed ID: 16843668
    [Abstract] [Full Text] [Related]

  • 2. New quinoxaline 1, 4-di-N-oxides: anticancer and hypoxia-selective therapeutic agents.
    Ismail MM, Amin KM, Noaman E, Soliman DH, Ammar YA.
    Eur J Med Chem; 2010 Jul 15; 45(7):2733-8. PubMed ID: 20236735
    [Abstract] [Full Text] [Related]

  • 3. Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides.
    Monge A, Palop JA, López de Ceráin A, Senador V, Martínez-Crespo FJ, Sainz Y, Narro S, García E, de Miguel C, González M.
    J Med Chem; 1995 May 12; 38(10):1786-92. PubMed ID: 7752202
    [Abstract] [Full Text] [Related]

  • 4. Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives.
    Vieites M, Noblía P, Torre MH, Cerecetto H, Laura Lavaggi M, Costa-Filho AJ, Azqueta A, de Cerain AL, Monge A, Parajón-Costa B, González M, Gambino D.
    J Inorg Biochem; 2006 Aug 12; 100(8):1358-67. PubMed ID: 16698084
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives.
    Zarranz B, Jaso A, Aldana I, Monge A.
    Bioorg Med Chem; 2004 Jul 01; 12(13):3711-21. PubMed ID: 15186857
    [Abstract] [Full Text] [Related]

  • 6. Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs.
    Urquiola C, Vieites M, Torre MH, Cabrera M, Lavaggi ML, Cerecetto H, González M, Cerain AL, Monge A, Smircich P, Garat B, Gambino D.
    Bioorg Med Chem; 2009 Feb 15; 17(4):1623-9. PubMed ID: 19162490
    [Abstract] [Full Text] [Related]

  • 7. Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation.
    Yin H, Xu Y, Qian X, Li Y, Liu J.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2166-70. PubMed ID: 17331719
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.
    Solano B, Junnotula V, Marín A, Villar R, Burguete A, Vicente E, Pérez-Silanes S, Aldana I, Monge A, Dutta S, Sarkar U, Gates KS.
    J Med Chem; 2007 Nov 01; 50(22):5485-92. PubMed ID: 17910426
    [Abstract] [Full Text] [Related]

  • 9. Hypoxic cells in tumors as a target for cancer therapy.
    Gali-Muhtasib HU, Diab-Assef M, Haddadin MJ.
    J Med Liban; 2002 Nov 01; 50(4):175-9. PubMed ID: 15298478
    [Abstract] [Full Text] [Related]

  • 10. Novel N-oxides as bioreductive drugs.
    Naylor MA.
    Oncol Res; 1994 Nov 01; 6(10-11):483-91. PubMed ID: 7620216
    [Abstract] [Full Text] [Related]

  • 11. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
    [Abstract] [Full Text] [Related]

  • 12. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH, Wilson WR, Denny WA.
    Anticancer Drug Des; 1999 Dec 02; 14(6):487-97. PubMed ID: 10834270
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides.
    Grande F, Aiello F, Grazia OD, Brizzi A, Garofalo A, Neamati N.
    Bioorg Med Chem; 2007 Jan 01; 15(1):288-94. PubMed ID: 17085054
    [Abstract] [Full Text] [Related]

  • 14. Selective activity against Mycobacteriumtuberculosis of new quinoxaline 1,4-di-N-oxides.
    Vicente E, Pérez-Silanes S, Lima LM, Ancizu S, Burguete A, Solano B, Villar R, Aldana I, Monge A.
    Bioorg Med Chem; 2009 Jan 01; 17(1):385-9. PubMed ID: 19058970
    [Abstract] [Full Text] [Related]

  • 15. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
    Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2004 Jan 15; 47(2):475-88. PubMed ID: 14711317
    [Abstract] [Full Text] [Related]

  • 16. Quinoxaline 1,4-dioxides as anticancer and hypoxia-selective drugs.
    Gali-Muhtasib HU, Haddadin MJ, Rahhal DN, Younes IH.
    Oncol Rep; 2001 Jan 15; 8(3):679-84. PubMed ID: 11295102
    [Abstract] [Full Text] [Related]

  • 17. 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part II.
    Cerecetto H, González M, Onetto S, Saenz P, Ezpeleta O, De Ceráin AL, Monge A.
    Arch Pharm (Weinheim); 2004 May 15; 337(5):247-58. PubMed ID: 15095418
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers.
    Sanmartín C, Echeverría M, Mendívil B, Cordeu L, Cubedo E, García-Foncillas J, Font M, Palop JA.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2031-44. PubMed ID: 15727857
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and in vitro-anticancer and antimicrobial evaluation of some novel quinoxalines derived from 3-phenylquinoxaline-2(1H)-thione.
    El-Hawash SA, Wahab AE.
    Arch Pharm (Weinheim); 2006 Aug 15; 339(8):437-47. PubMed ID: 16881038
    [Abstract] [Full Text] [Related]

  • 20. Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides. 2.
    Monge A, Martínez-Crespo FJ, López de Ceráin A, Palop JA, Narro S, Senador V, Marín A, Sainz Y, González M, Hamilton E.
    J Med Chem; 1995 Oct 27; 38(22):4488-94. PubMed ID: 7473576
    [Abstract] [Full Text] [Related]

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