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Journal Abstract Search

439 related items for PubMed ID: 16857725

  • 1. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.
    Itoh M, Nakajima M, Higashi E, Yoshida R, Nagata K, Yamazoe Y, Yokoi T.
    J Pharmacol Exp Ther; 2006 Nov; 319(2):693-702. PubMed ID: 16857725
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  • 2. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.
    Ferguson SS, Chen Y, LeCluyse EL, Negishi M, Goldstein JA.
    Mol Pharmacol; 2005 Sep; 68(3):747-57. PubMed ID: 15933212
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  • 3. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
    Bhalla S, Ozalp C, Fang S, Xiang L, Kemper JK.
    J Biol Chem; 2004 Oct 22; 279(43):45139-47. PubMed ID: 15322103
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  • 4. Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.
    Arpiainen S, Järvenpää SM, Manninen A, Viitala P, Lang MA, Pelkonen O, Hakkola J.
    Toxicol Appl Pharmacol; 2008 Oct 01; 232(1):135-41. PubMed ID: 18602936
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  • 5. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, Ulrichova J, Anzenbacher P, Pavek P.
    Drug Metab Dispos; 2007 Jul 01; 35(7):1032-41. PubMed ID: 17392393
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  • 6. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T, Chiang JY.
    Drug Metab Dispos; 2006 May 01; 34(5):756-64. PubMed ID: 16455805
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  • 7. The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.
    Chen Y, Kissling G, Negishi M, Goldstein JA.
    J Pharmacol Exp Ther; 2005 Sep 01; 314(3):1125-33. PubMed ID: 15919766
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  • 9. Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
    Martínez-Jiménez CP, Castell JV, Gómez-Lechón MJ, Jover R.
    Mol Pharmacol; 2006 Nov 01; 70(5):1681-92. PubMed ID: 16882880
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  • 16. MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1).
    Li M, Yang Y, He ZX, Zhou ZW, Yang T, Guo P, Zhang X, Zhou SF.
    Drug Metab Dispos; 2014 Jan 01; 42(1):44-61. PubMed ID: 24104199
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  • 17. Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element.
    Liu D, Zhang Z, Teng CT.
    J Mol Endocrinol; 2005 Apr 01; 34(2):473-87. PubMed ID: 15821111
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  • 18. Modulation of hepatocyte nuclear factor-4alpha function by the peroxisome-proliferator-activated receptor-gamma co-activator-1alpha in the acute-phase response.
    Wang Z, Burke PA.
    Biochem J; 2008 Oct 15; 415(2):289-96. PubMed ID: 18510493
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  • 19. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S.
    Drug Metab Pharmacokinet; 2012 Oct 15; 27(4):430-8. PubMed ID: 22333269
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  • 20. Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.
    Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.
    J Biochem Mol Toxicol; 2009 Oct 15; 23(1):43-58. PubMed ID: 19202563
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