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770 related items for PubMed ID: 16870158

  • 1. Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.
    Geraets L, Moonen HJ, Wouters EF, Bast A, Hageman GJ.
    Biochem Pharmacol; 2006 Sep 28; 72(7):902-10. PubMed ID: 16870158
    [Abstract] [Full Text] [Related]

  • 2. Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.
    Geraets L, Moonen HJ, Brauers K, Gottschalk RW, Wouters EF, Bast A, Hageman GJ.
    Eur J Pharmacol; 2007 Nov 14; 573(1-3):241-8. PubMed ID: 17643414
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.
    Geraets L, Haegens A, Weseler AR, Brauers K, Vernooy JH, Wouters EF, Bast A, Hageman GJ.
    Eur J Pharmacol; 2010 Mar 10; 629(1-3):132-9. PubMed ID: 19962977
    [Abstract] [Full Text] [Related]

  • 4. PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.
    Mathews MT, Berk BC.
    Arterioscler Thromb Vasc Biol; 2008 Apr 10; 28(4):711-7. PubMed ID: 18239155
    [Abstract] [Full Text] [Related]

  • 5. Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders.
    Henning RJ, Bourgeois M, Harbison RD.
    Cardiovasc Toxicol; 2018 Dec 10; 18(6):493-506. PubMed ID: 29968072
    [Abstract] [Full Text] [Related]

  • 6. Theophylline prevents NAD+ depletion via PARP-1 inhibition in human pulmonary epithelial cells.
    Moonen HJ, Geraets L, Vaarhorst A, Bast A, Wouters EF, Hageman GJ.
    Biochem Biophys Res Commun; 2005 Dec 30; 338(4):1805-10. PubMed ID: 16289039
    [Abstract] [Full Text] [Related]

  • 7. Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
    Virág L.
    Curr Vasc Pharmacol; 2005 Jul 30; 3(3):209-14. PubMed ID: 16026317
    [Abstract] [Full Text] [Related]

  • 8. Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.
    Lin CH, Lin PH.
    Chem Biol Interact; 2006 Aug 25; 162(2):181-94. PubMed ID: 16884709
    [Abstract] [Full Text] [Related]

  • 9. Thrombin or Ca(++)-ionophore-mediated fall in endothelial ATP levels independent of poly(ADP-Ribose) polymerase activity and NAD levels--comparison with the effects of hydrogen peroxide.
    Halldórsson H, Thors B, Thorgeirsson G.
    Nucleosides Nucleotides Nucleic Acids; 2015 Aug 25; 34(4):246-57. PubMed ID: 25774718
    [Abstract] [Full Text] [Related]

  • 10. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.
    Iwashita A, Tojo N, Matsuura S, Yamazaki S, Kamijo K, Ishida J, Yamamoto H, Hattori K, Matsuoka N, Mutoh S.
    J Pharmacol Exp Ther; 2004 Aug 25; 310(2):425-36. PubMed ID: 15075382
    [Abstract] [Full Text] [Related]

  • 11. An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors.
    Putt KS, Hergenrother PJ.
    Anal Biochem; 2004 Mar 01; 326(1):78-86. PubMed ID: 14769338
    [Abstract] [Full Text] [Related]

  • 12. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
    Schraufstatter IU, Hyslop PA, Hinshaw DB, Spragg RG, Sklar LA, Cochrane CG.
    Proc Natl Acad Sci U S A; 1986 Jul 01; 83(13):4908-12. PubMed ID: 2941760
    [Abstract] [Full Text] [Related]

  • 13. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase.
    Kirkland JB.
    Biochim Biophys Acta; 1991 May 17; 1092(3):319-25. PubMed ID: 1904775
    [Abstract] [Full Text] [Related]

  • 14. NAD+ as a metabolic link between DNA damage and cell death.
    Ying W, Alano CC, Garnier P, Swanson RA.
    J Neurosci Res; 1991 May 17; 79(1-2):216-23. PubMed ID: 15562437
    [Abstract] [Full Text] [Related]

  • 15. Poly(ADP-ribosyl)ation enhancement in brain cell nuclei is associated with diabetic neuropathy.
    Kuchmerovska T, Shymanskyy I, Donchenko G, Kuchmerovskyy M, Pakirbaieva L, Klimenko A.
    J Diabetes Complications; 2004 May 17; 18(4):198-204. PubMed ID: 15207836
    [Abstract] [Full Text] [Related]

  • 16. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.
    Lin PH, Lin CH, Huang CC, Chuang MC, Lin P.
    Toxicol Lett; 2007 Aug 17; 172(3):146-58. PubMed ID: 17669606
    [Abstract] [Full Text] [Related]

  • 17. Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death.
    Ying W, Sevigny MB, Chen Y, Swanson RA.
    Proc Natl Acad Sci U S A; 2001 Oct 09; 98(21):12227-32. PubMed ID: 11593040
    [Abstract] [Full Text] [Related]

  • 18. Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death.
    Kovács K, Erdélyi K, Hegedűs C, Lakatos P, Regdon Z, Bai P, Haskó G, Szabó E, Virág L.
    Free Radic Biol Med; 2012 Nov 01; 53(9):1680-8. PubMed ID: 22964577
    [Abstract] [Full Text] [Related]

  • 19. Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations.
    Alano CC, Kauppinen TM, Valls AV, Swanson RA.
    Proc Natl Acad Sci U S A; 2006 Jun 20; 103(25):9685-90. PubMed ID: 16769901
    [Abstract] [Full Text] [Related]

  • 20. Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury.
    Cole KK, Perez-Polo JR.
    J Neurochem; 2002 Jul 20; 82(1):19-29. PubMed ID: 12091461
    [Abstract] [Full Text] [Related]

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