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118 related items for PubMed ID: 16870430

  • 1. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Patel CH, Dhanani S, Owen CP, Ahmed S.
    Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4752-6. PubMed ID: 16870430
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 Jul 15; 111(1-2):117-27. PubMed ID: 18620055
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  • 3. Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).
    Shahid I, Patel CH, Dhanani S, Owen CP, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 May 15; 110(1-2):18-29. PubMed ID: 18407491
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Dhanani S, Patel CH, Shahid I, Ahmed S.
    Bioorg Med Chem Lett; 2006 Aug 01; 16(15):4011-5. PubMed ID: 16750362
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  • 5. Synthesis and biological evaluation of imidazole based compounds as cytochrome P-450 inhibitors.
    Ahmed S, Smith JH, Nicholls PJ, Whomsley R, Cariuk P.
    Drug Des Discov; 1995 Aug 01; 13(1):27-41. PubMed ID: 8882899
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  • 6. Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.
    Owen CP, Shahid I, Lee WY, Ahmed S.
    Bioorg Med Chem Lett; 2010 Sep 01; 20(17):5345-8. PubMed ID: 20675132
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  • 11. Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
    Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.
    Bioorg Med Chem; 2008 Aug 15; 16(16):7715-27. PubMed ID: 18674917
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  • 12. Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.
    Nakamura T, Ishii T, Miyata N, Taniguchi K, Tomishima Y, Ueki T, Sato M.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5305-8. PubMed ID: 15454216
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  • 13. Ones, thiones, and N-oxides: an exercise in imidazole chemistry.
    Laufer S, Wagner G, Kotschenreuther D.
    Angew Chem Int Ed Engl; 2002 Jul 02; 41(13):2290-3. PubMed ID: 12203569
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  • 14. Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer.
    Wachall BG, Hector M, Zhuang Y, Hartmann RW.
    Bioorg Med Chem; 1999 Sep 02; 7(9):1913-24. PubMed ID: 10530940
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  • 15. Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
    Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW.
    Bioorg Med Chem; 2008 Feb 15; 16(4):1992-2010. PubMed ID: 18061460
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  • 16. 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
    Ling YZ, Li JS, Liu Y, Kato K, Klus GT, Brodie A.
    J Med Chem; 1997 Sep 26; 40(20):3297-304. PubMed ID: 9379450
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  • 17. The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17alpha-hydroxylase and 17,20-lyase.
    Ahmed S.
    Biochem Biophys Res Commun; 2004 Apr 09; 316(3):595-8. PubMed ID: 15033441
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  • 18. The use of the substrate-heme complex approach in the design, synthesis, biochemical evaluation, and rationalization of the inhibitory activity of a range of azole compounds against cholesterol side chain cleavage enzyme.
    Ahmed S.
    Biochem Biophys Res Commun; 2000 Aug 18; 275(1):75-6. PubMed ID: 10944444
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  • 19. Crystal structure of inhibitor-bound P450BM-3 reveals open conformation of substrate access channel.
    Haines DC, Chen B, Tomchick DR, Bondlela M, Hegde A, Machius M, Peterson JA.
    Biochemistry; 2008 Mar 25; 47(12):3662-70. PubMed ID: 18298086
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  • 20. Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
    Lin NH, Wang L, Wang X, Wang GT, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL.
    Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5057-62. PubMed ID: 15380198
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