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598 related items for PubMed ID: 16872277

  • 1. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
    Zhang Y, Crouch DH, Yamamoto M, Hayes JD.
    Biochem J; 2006 Nov 01; 399(3):373-85. PubMed ID: 16872277
    [Abstract] [Full Text] [Related]

  • 2. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).
    Tian W, Rojo de la Vega M, Schmidlin CJ, Ooi A, Zhang DD.
    J Biol Chem; 2018 Feb 09; 293(6):2029-2040. PubMed ID: 29255090
    [Abstract] [Full Text] [Related]

  • 3. Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
    Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):342-50. PubMed ID: 15581590
    [Abstract] [Full Text] [Related]

  • 4. The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression.
    Zhang Y, Qiu L, Li S, Xiang Y, Chen J, Ren Y.
    PLoS One; 2014 Jan 15; 9(10):e109159. PubMed ID: 25290918
    [Abstract] [Full Text] [Related]

  • 5. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.
    Wang W, Chan JY.
    J Biol Chem; 2006 Jul 14; 281(28):19676-87. PubMed ID: 16687406
    [Abstract] [Full Text] [Related]

  • 6. Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
    Velichkova M, Hasson T.
    Mol Cell Biol; 2005 Jun 14; 25(11):4501-13. PubMed ID: 15899855
    [Abstract] [Full Text] [Related]

  • 7. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
    McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD.
    J Biol Chem; 2004 Jul 23; 279(30):31556-67. PubMed ID: 15143058
    [Abstract] [Full Text] [Related]

  • 8. Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane.
    Zhang Y, Hayes JD.
    Biochem J; 2010 Sep 15; 430(3):497-510. PubMed ID: 20629635
    [Abstract] [Full Text] [Related]

  • 9. Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
    Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M.
    Mol Cell Biol; 2006 Apr 15; 26(8):2887-900. PubMed ID: 16581765
    [Abstract] [Full Text] [Related]

  • 10. Subcellular localization and cytoplasmic complex status of endogenous Keap1.
    Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M.
    Genes Cells; 2007 Oct 15; 12(10):1163-78. PubMed ID: 17903176
    [Abstract] [Full Text] [Related]

  • 11. KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
    Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD.
    Mol Cell Biol; 2011 May 15; 31(9):1800-11. PubMed ID: 21383067
    [Abstract] [Full Text] [Related]

  • 12. The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.
    Zhang Y, Lucocq JM, Yamamoto M, Hayes JD.
    Biochem J; 2007 Dec 01; 408(2):161-72. PubMed ID: 17705787
    [Abstract] [Full Text] [Related]

  • 13. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation.
    Nioi P, Nguyen T, Sherratt PJ, Pickett CB.
    Mol Cell Biol; 2005 Dec 01; 25(24):10895-906. PubMed ID: 16314513
    [Abstract] [Full Text] [Related]

  • 14. Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.
    He X, Ma Q.
    J Pharmacol Exp Ther; 2010 Jan 01; 332(1):66-75. PubMed ID: 19808700
    [Abstract] [Full Text] [Related]

  • 15. Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
    Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M.
    EMBO J; 2006 Aug 09; 25(15):3605-17. PubMed ID: 16888629
    [Abstract] [Full Text] [Related]

  • 16. Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.
    Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A.
    Free Radic Biol Med; 2012 Jan 15; 52(2):473-87. PubMed ID: 22142471
    [Abstract] [Full Text] [Related]

  • 17. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
    Sun Z, Zhang S, Chan JY, Zhang DD.
    Mol Cell Biol; 2007 Sep 15; 27(18):6334-49. PubMed ID: 17636022
    [Abstract] [Full Text] [Related]

  • 18. The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
    Zipper LM, Mulcahy RT.
    J Biol Chem; 2002 Sep 27; 277(39):36544-52. PubMed ID: 12145307
    [Abstract] [Full Text] [Related]

  • 19. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association.
    He X, Lin GX, Chen MG, Zhang JX, Ma Q.
    Toxicol Sci; 2007 Jul 27; 98(1):298-309. PubMed ID: 17420218
    [Abstract] [Full Text] [Related]

  • 20. Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle.
    Li T, He S, Liu S, Kong Z, Wang J, Zhang Y.
    Free Radic Res; 2015 Oct 27; 49(10):1269-74. PubMed ID: 26118597
    [Abstract] [Full Text] [Related]

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