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262 related items for PubMed ID: 16882765

  • 1. Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.
    Hallifax D, Houston JB.
    Drug Metab Dispos; 2006 Nov; 34(11):1829-36. PubMed ID: 16882765
    [Abstract] [Full Text] [Related]

  • 2. Saturable uptake of lipophilic amine drugs into isolated hepatocytes: mechanisms and consequences for quantitative clearance prediction.
    Hallifax D, Houston JB.
    Drug Metab Dispos; 2007 Aug; 35(8):1325-32. PubMed ID: 17470525
    [Abstract] [Full Text] [Related]

  • 3. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
    Obach RS.
    Drug Metab Dispos; 1997 Dec; 25(12):1359-69. PubMed ID: 9394025
    [Abstract] [Full Text] [Related]

  • 4. Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir.
    Parker AJ, Houston JB.
    Drug Metab Dispos; 2008 Jul; 36(7):1375-84. PubMed ID: 18426953
    [Abstract] [Full Text] [Related]

  • 5. Quantitative prediction of the in vivo inhibition of diazepam metabolism by omeprazole using rat liver microsomes and hepatocytes.
    Jones HM, Hallifax D, Houston JB.
    Drug Metab Dispos; 2004 May; 32(5):572-80. PubMed ID: 15100181
    [Abstract] [Full Text] [Related]

  • 6. Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.
    Morita N, Kusuhara H, Nozaki Y, Endou H, Sugiyama Y.
    Drug Metab Dispos; 2005 Aug; 33(8):1151-7. PubMed ID: 15900017
    [Abstract] [Full Text] [Related]

  • 7. Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats.
    Han X, Yang CH, Snajdr SI, Nabb DL, Mingoia RT.
    Toxicol Lett; 2008 Sep 26; 181(2):81-6. PubMed ID: 18662756
    [Abstract] [Full Text] [Related]

  • 8. Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
    Watanabe T, Maeda K, Kondo T, Nakayama H, Horita S, Kusuhara H, Sugiyama Y.
    Drug Metab Dispos; 2009 Jul 26; 37(7):1471-9. PubMed ID: 19364828
    [Abstract] [Full Text] [Related]

  • 9. Comparative use of isolated hepatocytes and hepatic microsomes for cytochrome P450 inhibition studies: transporter-enzyme interplay.
    Brown HS, Wilby AJ, Alder J, Houston JB.
    Drug Metab Dispos; 2010 Dec 26; 38(12):2139-46. PubMed ID: 20847136
    [Abstract] [Full Text] [Related]

  • 10. Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions.
    McGinnity DF, Waters NJ, Tucker J, Riley RJ.
    Drug Metab Dispos; 2008 Jun 26; 36(6):1126-34. PubMed ID: 18356267
    [Abstract] [Full Text] [Related]

  • 11. Carrier-mediated active transport of histamine H2 receptor antagonists, cimetidine and nizatidine, into isolated rat hepatocytes: contribution of type I system.
    Nakamura H, Sano H, Yamazaki M, Sugiyama Y.
    J Pharmacol Exp Ther; 1994 Jun 26; 269(3):1220-7. PubMed ID: 7912279
    [Abstract] [Full Text] [Related]

  • 12. Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs.
    Ishizaki J, Yokogawa K, Ichimura F, Ohkuma S.
    J Pharmacol Exp Ther; 2000 Sep 26; 294(3):1088-98. PubMed ID: 10945864
    [Abstract] [Full Text] [Related]

  • 13. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.
    Lam JL, Benet LZ.
    Drug Metab Dispos; 2004 Nov 26; 32(11):1311-6. PubMed ID: 15483198
    [Abstract] [Full Text] [Related]

  • 14. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.
    Shibata Y, Takahashi H, Ishii Y.
    Drug Metab Dispos; 2000 Dec 26; 28(12):1518-23. PubMed ID: 11095592
    [Abstract] [Full Text] [Related]

  • 15. Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist.
    Imawaka H, Sugiyama Y.
    J Pharmacol Exp Ther; 1998 Mar 26; 284(3):949-57. PubMed ID: 9495854
    [Abstract] [Full Text] [Related]

  • 16. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
    Griffin SJ, Houston JB.
    Drug Metab Dispos; 2004 May 26; 32(5):552-8. PubMed ID: 15100178
    [Abstract] [Full Text] [Related]

  • 17. The metabolism of propranolol (ICI 45,520, Inderal) and xamoterol (ICI 118,587, Corwin) by isolated rat hepatocytes: in vivo-in vitro correlations.
    McCormick DJ, Fitzgerald TC, McKillop D.
    Xenobiotica; 1988 Dec 26; 18(12):1401-12. PubMed ID: 2977458
    [Abstract] [Full Text] [Related]

  • 18. Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.
    Watanabe T, Kusuhara H, Maeda K, Kanamaru H, Saito Y, Hu Z, Sugiyama Y.
    Drug Metab Dispos; 2010 Feb 26; 38(2):215-22. PubMed ID: 19875501
    [Abstract] [Full Text] [Related]

  • 19. Functional consequences of active hepatic uptake on cytochrome P450 inhibition in rat and human hepatocytes.
    Grime K, Webborn PJ, Riley RJ.
    Drug Metab Dispos; 2008 Aug 26; 36(8):1670-8. PubMed ID: 18474678
    [Abstract] [Full Text] [Related]

  • 20. Alteration of the pharmacokinetics and metabolism of propranolol and antipyrine elicited by indwelling catheters in the rat.
    Chindavijak B, Belpaire FM, De Smet F, Bogaert MG.
    J Pharmacol Exp Ther; 1988 Sep 26; 246(3):1075-9. PubMed ID: 3418510
    [Abstract] [Full Text] [Related]

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