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PUBMED FOR HANDHELDS

Journal Abstract Search

98 related items for PubMed ID: 16882766

  • 1. Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.
    Sridar C, Kobayashi Y, Brevig H, Kent UM, Puppali SG, Rimoldi JM, Hollenberg PF.
    Drug Metab Dispos; 2006 Nov; 34(11):1849-55. PubMed ID: 16882766
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.
    Kobayashi Y, Sridar C, Kent UM, Puppali SG, Rimoldi JM, Zhang H, Waskell L, Hollenberg PF.
    Drug Metab Dispos; 2006 Dec; 34(12):2102-10. PubMed ID: 16997911
    [Abstract] [Full Text] [Related]

  • 3. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
    Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF.
    Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
    [Abstract] [Full Text] [Related]

  • 4. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2005 Apr; 313(1):154-64. PubMed ID: 15608076
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  • 6. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by n-propylxanthate.
    Kent UM, Yanev S, Hollenberg PF.
    Chem Res Toxicol; 1999 Apr; 12(4):317-22. PubMed ID: 10207119
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  • 8. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
    Harleton E, Webster M, Bumpus NN, Kent UM, Rae JM, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Sep; 310(3):1011-9. PubMed ID: 15121764
    [Abstract] [Full Text] [Related]

  • 9. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Kent UM, Hollenberg PF.
    Drug Metab Dispos; 2003 Jan; 31(1):46-52. PubMed ID: 12485952
    [Abstract] [Full Text] [Related]

  • 10. The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.
    Bumpus NN, Sridar C, Kent UM, Hollenberg PF.
    Drug Metab Dispos; 2005 Jun; 33(6):795-802. PubMed ID: 15769884
    [Abstract] [Full Text] [Related]

  • 11. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
    [Abstract] [Full Text] [Related]

  • 12. Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms.
    Bumpus NN, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2006 Jul; 318(1):345-51. PubMed ID: 16611850
    [Abstract] [Full Text] [Related]

  • 13. Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine.
    Shebley M, Hollenberg PF.
    Drug Metab Dispos; 2007 Aug; 35(8):1365-71. PubMed ID: 17460030
    [Abstract] [Full Text] [Related]

  • 14. Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Wahlstrom JL, Hollenberg PF, Wienkers LC.
    Drug Metab Dispos; 2006 Sep; 34(9):1523-9. PubMed ID: 16782764
    [Abstract] [Full Text] [Related]

  • 15. Mechanism-based inactivation of cytochrome P450 2B6 by a novel terminal acetylene inhibitor.
    Fan PW, Gu C, Marsh SA, Stevens JC.
    Drug Metab Dispos; 2003 Jan; 31(1):28-36. PubMed ID: 12485950
    [Abstract] [Full Text] [Related]

  • 16. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
    Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF.
    Drug Metab Dispos; 2004 Jun; 32(6):587-94. PubMed ID: 15155549
    [Abstract] [Full Text] [Related]

  • 17. Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates.
    Yanev S, Kent UM, Pandova B, Hollenberg PF.
    Drug Metab Dispos; 1999 May; 27(5):600-4. PubMed ID: 10220489
    [Abstract] [Full Text] [Related]

  • 18. Metabolic activation of mifepristone [RU486; 17beta-hydroxy-11beta-(4-dimethylaminophenyl)-17alpha-(1-propynyl)-estra-4,9-dien-3-one] by mammalian cytochromes P450 and the mechanism-based inactivation of human CYP2B6.
    Lin HL, Zhang H, Hollenberg PF.
    J Pharmacol Exp Ther; 2009 Apr; 329(1):26-37. PubMed ID: 19168709
    [Abstract] [Full Text] [Related]

  • 19. Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.
    Amunugama HT, Zhang H, Hollenberg PF.
    Drug Metab Dispos; 2012 Sep; 40(9):1765-70. PubMed ID: 22685215
    [Abstract] [Full Text] [Related]

  • 20. Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.
    Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP.
    Chem Res Toxicol; 1997 Jan; 10(1):91-102. PubMed ID: 9074808
    [Abstract] [Full Text] [Related]

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