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Journal Abstract Search

179 related items for PubMed ID: 16884308

  • 1. The physicochemical challenges of designing multiple ligands.
    Morphy R, Rankovic Z.
    J Med Chem; 2006 Aug 10; 49(16):4961-70. PubMed ID: 16884308
    [Abstract] [Full Text] [Related]

  • 2. The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds.
    Morphy R.
    J Med Chem; 2006 May 18; 49(10):2969-78. PubMed ID: 16686538
    [Abstract] [Full Text] [Related]

  • 3. Oral delivery of G protein-coupled receptor modulators: an explanation for the observed class difference.
    Beaumont K, Schmid E, Smith DA.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3658-64. PubMed ID: 15982884
    [Abstract] [Full Text] [Related]

  • 4. Current status of virtual screening as analysed by target class.
    Stoermer MJ.
    Med Chem; 2006 Jan 15; 2(1):89-112. PubMed ID: 16787359
    [Abstract] [Full Text] [Related]

  • 5. GLIDA: GPCR-ligand database for chemical genomic drug discovery.
    Okuno Y, Yang J, Taneishi K, Yabuuchi H, Tsujimoto G.
    Nucleic Acids Res; 2006 Jan 01; 34(Database issue):D673-7. PubMed ID: 16381956
    [Abstract] [Full Text] [Related]

  • 6. Time-related differences in the physical property profiles of oral drugs.
    Leeson PD, Davis AM.
    J Med Chem; 2004 Dec 02; 47(25):6338-48. PubMed ID: 15566303
    [Abstract] [Full Text] [Related]

  • 7. Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery.
    Fink T, Reymond JL.
    J Chem Inf Model; 2007 Dec 02; 47(2):342-53. PubMed ID: 17260980
    [Abstract] [Full Text] [Related]

  • 8. Rational Modification of the Biological Profile of GPCR Ligands through Combination with Other Biologically Active Moieties.
    Huang G, Nimczick M, Decker M.
    Arch Pharm (Weinheim); 2015 Aug 02; 348(8):531-40. PubMed ID: 25941009
    [Abstract] [Full Text] [Related]

  • 9. Designing active template molecules by combining computational de novo design and human chemist's expertise.
    Lameijer EW, Tromp RA, Spanjersberg RF, Brussee J, Ijzerman AP.
    J Med Chem; 2007 Apr 19; 50(8):1925-32. PubMed ID: 17367122
    [Abstract] [Full Text] [Related]

  • 10. Fragments, network biology and designing multiple ligands.
    Morphy R, Rankovic Z.
    Drug Discov Today; 2007 Feb 19; 12(3-4):156-60. PubMed ID: 17275736
    [Abstract] [Full Text] [Related]

  • 11. Physicochemical effects in the representation of molecular structures for drug designing.
    Gasteiger J.
    Mini Rev Med Chem; 2003 Dec 19; 3(8):789-96. PubMed ID: 14529498
    [Abstract] [Full Text] [Related]

  • 12. A comparison of physiochemical property profiles of development and marketed oral drugs.
    Wenlock MC, Austin RP, Barton P, Davis AM, Leeson PD.
    J Med Chem; 2003 Mar 27; 46(7):1250-6. PubMed ID: 12646035
    [Abstract] [Full Text] [Related]

  • 13. Are target-family-privileged substructures truly privileged?
    Schnur DM, Hermsmeier MA, Tebben AJ.
    J Med Chem; 2006 Mar 23; 49(6):2000-9. PubMed ID: 16539387
    [Abstract] [Full Text] [Related]

  • 14. Investigation of the relationship between topology and selectivity for druglike molecules.
    Yang Y, Chen H, Nilsson I, Muresan S, Engkvist O.
    J Med Chem; 2010 Nov 11; 53(21):7709-14. PubMed ID: 20942392
    [Abstract] [Full Text] [Related]

  • 15. Novel 2D fingerprints for ligand-based virtual screening.
    Ewing T, Baber JC, Feher M.
    J Chem Inf Model; 2006 Nov 11; 46(6):2423-31. PubMed ID: 17125184
    [Abstract] [Full Text] [Related]

  • 16. Intramolecular hydrogen bonding in medicinal chemistry.
    Kuhn B, Mohr P, Stahl M.
    J Med Chem; 2010 Mar 25; 53(6):2601-11. PubMed ID: 20175530
    [Abstract] [Full Text] [Related]

  • 17. The role and significance of unconventional hydrogen bonds in small molecule recognition by biological receptors of pharmaceutical relevance.
    Tóth G, Bowers SG, Truong AP, Probst G.
    Curr Pharm Des; 2007 Mar 25; 13(34):3476-93. PubMed ID: 18220785
    [Abstract] [Full Text] [Related]

  • 18. Knowledge-based chemoinformatic approaches to drug discovery.
    Ghose AK, Herbertz T, Salvino JM, Mallamo JP.
    Drug Discov Today; 2006 Dec 25; 11(23-24):1107-14. PubMed ID: 17129830
    [Abstract] [Full Text] [Related]

  • 19. Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocols.
    Evers A, Hessler G, Matter H, Klabunde T.
    J Med Chem; 2005 Aug 25; 48(17):5448-65. PubMed ID: 16107144
    [Abstract] [Full Text] [Related]

  • 20. Knowledge-based analysis of multi-potent G-protein coupled receptors ligands.
    Faure P, Dubus E, Ijjaali I, Morlière C, Barberan O, Petitet F.
    Eur J Med Chem; 2010 Dec 25; 45(12):5708-17. PubMed ID: 20933307
    [Abstract] [Full Text] [Related]

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