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Journal Abstract Search

626 related items for PubMed ID: 16889227

  • 1. Expediting drug discovery: recent advances in fast medicinal chemistry--optimization of hits and leads.
    Edwards PJ, Allart B, Andrews MJ, Clase JA, Menet C.
    Curr Opin Drug Discov Devel; 2006 Jul; 9(4):425-44. PubMed ID: 16889227
    [Abstract] [Full Text] [Related]

  • 2. Current parallel chemistry principles and practice: application to the discovery of biologically active molecules.
    Edwards PJ.
    Curr Opin Drug Discov Devel; 2009 Nov; 12(6):899-914. PubMed ID: 19894197
    [Abstract] [Full Text] [Related]

  • 3. Solid-phase compound library synthesis in drug design and development.
    Edwards PJ, Morrell AI.
    Curr Opin Drug Discov Devel; 2002 Jul; 5(4):594-605. PubMed ID: 12197317
    [Abstract] [Full Text] [Related]

  • 4. Current directions in the evolution of compound libraries.
    Webb TR.
    Curr Opin Drug Discov Devel; 2005 May; 8(3):303-8. PubMed ID: 15892244
    [Abstract] [Full Text] [Related]

  • 5. Timely synthetic support for medicinal chemists.
    Potoski J.
    Drug Discov Today; 2005 Jan 15; 10(2):115-20. PubMed ID: 15718160
    [Abstract] [Full Text] [Related]

  • 6. Calculation and application of activity discriminants in lead optimization.
    Luo X, Krumrine JR, Shenvi AB, Pierson ME, Bernstein PR.
    J Mol Graph Model; 2010 Nov 15; 29(3):372-81. PubMed ID: 20800520
    [Abstract] [Full Text] [Related]

  • 7. Metal complexes in medicinal chemistry: new vistas and challenges in drug design.
    Thompson KH, Orvig C.
    Dalton Trans; 2006 Feb 14; (6):761-4. PubMed ID: 16437168
    [Abstract] [Full Text] [Related]

  • 8. Synthetic library design.
    Huwe CM.
    Drug Discov Today; 2006 Aug 14; 11(15-16):763-7. PubMed ID: 16846805
    [Abstract] [Full Text] [Related]

  • 9. Molecular recognition: the fragment approach in lead generation.
    Fattori D.
    Drug Discov Today; 2004 Mar 01; 9(5):229-38. PubMed ID: 14980541
    [Abstract] [Full Text] [Related]

  • 10. From magic bullets to designed multiple ligands.
    Morphy R, Kay C, Rankovic Z.
    Drug Discov Today; 2004 Aug 01; 9(15):641-51. PubMed ID: 15279847
    [Abstract] [Full Text] [Related]

  • 11. Process technologies for purity enhancement of large discovery libraries.
    Pottorf RS, Player MR.
    Curr Opin Drug Discov Devel; 2004 Nov 01; 7(6):777-83. PubMed ID: 15595438
    [Abstract] [Full Text] [Related]

  • 12. The evolution of microarrayed compound screening.
    Hoever M, Zbinden P.
    Drug Discov Today; 2004 Apr 15; 9(8):358-65. PubMed ID: 15081963
    [Abstract] [Full Text] [Related]

  • 13. Highlighting the new advances in drug discovery and development.
    Taliani S, Da Settimo F.
    ChemMedChem; 2008 Jan 15; 3(1):181-4. PubMed ID: 18022978
    [No Abstract] [Full Text] [Related]

  • 14. [Drug discovery based on genomic information].
    Nohmi T.
    Rinsho Byori; 2002 Jul 15; 50(7):694-7. PubMed ID: 12187707
    [Abstract] [Full Text] [Related]

  • 15. Lead optimization via high-throughput molecular docking.
    Joseph-McCarthy D, Baber JC, Feyfant E, Thompson DC, Humblet C.
    Curr Opin Drug Discov Devel; 2007 May 15; 10(3):264-74. PubMed ID: 17554852
    [Abstract] [Full Text] [Related]

  • 16. Assessment of additive/nonadditive effects in structure-activity relationships: implications for iterative drug design.
    Patel Y, Gillet VJ, Howe T, Pastor J, Oyarzabal J, Willett P.
    J Med Chem; 2008 Dec 11; 51(23):7552-62. PubMed ID: 19012393
    [Abstract] [Full Text] [Related]

  • 17. Recent applications of microwave irradiation to medicinal chemistry.
    Alcázar J, Oehlrich D.
    Future Med Chem; 2010 Feb 11; 2(2):169-76. PubMed ID: 21426184
    [Abstract] [Full Text] [Related]

  • 18. Designing active template molecules by combining computational de novo design and human chemist's expertise.
    Lameijer EW, Tromp RA, Spanjersberg RF, Brussee J, Ijzerman AP.
    J Med Chem; 2007 Apr 19; 50(8):1925-32. PubMed ID: 17367122
    [Abstract] [Full Text] [Related]

  • 19. [Bioanalytics in medicinal chemistry: from assay development to evolutive drug design].
    Jose J.
    Ann Pharm Fr; 2009 Nov 19; 67(6):399-407. PubMed ID: 19900603
    [Abstract] [Full Text] [Related]

  • 20. A data mining method to facilitate SAR transfer.
    Wassermann AM, Bajorath J.
    J Chem Inf Model; 2011 Aug 22; 51(8):1857-66. PubMed ID: 21774471
    [Abstract] [Full Text] [Related]

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