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Journal Abstract Search

189 related items for PubMed ID: 16912264

  • 1. Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.
    Hicks KO, Pruijn FB, Secomb TW, Hay MP, Hsu R, Brown JM, Denny WA, Dewhirst MW, Wilson WR.
    J Natl Cancer Inst; 2006 Aug 16; 98(16):1118-28. PubMed ID: 16912264
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  • 2. Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.
    Hicks KO, Pruijn FB, Sturman JR, Denny WA, Wilson WR.
    Cancer Res; 2003 Sep 15; 63(18):5970-7. PubMed ID: 14522924
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  • 3. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
    Hicks KO, Siim BG, Jaiswal JK, Pruijn FB, Fraser AM, Patel R, Hogg A, Liyanage HD, Dorie MJ, Brown JM, Denny WA, Hay MP, Wilson WR.
    Clin Cancer Res; 2010 Oct 15; 16(20):4946-57. PubMed ID: 20732963
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  • 9. Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
    Hay MP, Hicks KO, Pruijn FB, Pchalek K, Siim BG, Wilson WR, Denny WA.
    J Med Chem; 2007 Dec 13; 50(25):6392-404. PubMed ID: 18001018
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  • 11. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
    Siim BG, Menke DR, Dorie MJ, Brown JM.
    Cancer Res; 1997 Jul 15; 57(14):2922-8. PubMed ID: 9230202
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  • 13. Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer.
    Wouters BG, Wang LH, Brown JM.
    Ann Oncol; 1999 Jul 15; 10 Suppl 5():S29-33. PubMed ID: 10582136
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  • 19. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
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  • 20. An investigation of the molecular basis for the synergistic interaction of tirapazamine and cisplatin.
    Goldberg Z, Evans J, Birrell G, Brown JM.
    Int J Radiat Oncol Biol Phys; 2001 Jan 01; 49(1):175-82. PubMed ID: 11163512
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