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124 related items for PubMed ID: 16913720

  • 1. Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors.
    Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD.
    J Med Chem; 2006 Aug 24; 49(17):5309-15. PubMed ID: 16913720
    [Abstract] [Full Text] [Related]

  • 2. Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors.
    Gududuru V, Zeng K, Tsukahara R, Makarova N, Fujiwara Y, Pigg KR, Baker DL, Tigyi G, Miller DD.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):451-6. PubMed ID: 16290140
    [Abstract] [Full Text] [Related]

  • 3. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.
    Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD.
    J Med Chem; 2003 Dec 18; 46(26):5575-8. PubMed ID: 14667211
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands.
    Durgam GG, Tsukahara R, Makarova N, Walker MD, Fujiwara Y, Pigg KR, Baker DL, Sardar VM, Parrill AL, Tigyi G, Miller DD.
    Bioorg Med Chem Lett; 2006 Feb 18; 16(3):633-40. PubMed ID: 16263282
    [Abstract] [Full Text] [Related]

  • 5. Synthesis of cyclic phosphonate analogues of (lyso)phosphatidic acid using a ring-closing metathesis reaction.
    Zhang H, Tsukuhara R, Tigyi G, Prestwich GD.
    J Org Chem; 2006 Aug 04; 71(16):6061-6. PubMed ID: 16872189
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
    Durgam GG, Virag T, Walker MD, Tsukahara R, Yasuda S, Liliom K, van Meeteren LA, Moolenaar WH, Wilke N, Siess W, Tigyi G, Miller DD.
    J Med Chem; 2005 Jul 28; 48(15):4919-30. PubMed ID: 16033271
    [Abstract] [Full Text] [Related]

  • 7. Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
    Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im DS, Nochi H, Tamoto K, Tomura H, Okajima F.
    Mol Pharmacol; 2003 Oct 28; 64(4):994-1005. PubMed ID: 14500756
    [Abstract] [Full Text] [Related]

  • 8. Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.
    Qian L, Xu Y, Simper T, Jiang G, Aoki J, Umezu-Goto M, Arai H, Yu S, Mills GB, Tsukahara R, Makarova N, Fujiwara Y, Tigyi G, Prestwich GD.
    ChemMedChem; 2006 Mar 28; 1(3):376-83. PubMed ID: 16892372
    [Abstract] [Full Text] [Related]

  • 9. Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques.
    Rother E, Brandl R, Baker DL, Goyal P, Gebhard H, Tigyi G, Siess W.
    Circulation; 2003 Aug 12; 108(6):741-7. PubMed ID: 12885756
    [Abstract] [Full Text] [Related]

  • 10. Structure-activity relationships of fluorinated lysophosphatidic acid analogues.
    Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD.
    J Med Chem; 2005 May 05; 48(9):3319-27. PubMed ID: 15857137
    [Abstract] [Full Text] [Related]

  • 11. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist.
    Heasley BH, Jarosz R, Lynch KR, Macdonald TL.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2735-40. PubMed ID: 15125924
    [Abstract] [Full Text] [Related]

  • 12.
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  • 13. Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid.
    Xu Y, Fang Y, Chen J, Prestwich GD.
    Bioorg Med Chem Lett; 2004 Mar 22; 14(6):1461-4. PubMed ID: 15006382
    [Abstract] [Full Text] [Related]

  • 14. Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
    Altman MK, Gopal V, Jia W, Yu S, Hall H, Mills GB, McGinnis AC, Bartlett MG, Jiang G, Madan D, Prestwich GD, Xu Y, Davies MA, Murph MM.
    Mol Cancer; 2010 Jun 09; 9():140. PubMed ID: 20529378
    [Abstract] [Full Text] [Related]

  • 15. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin.
    Khandoga AL, Fujiwara Y, Goyal P, Pandey D, Tsukahara R, Bolen A, Guo H, Wilke N, Liu J, Valentine WJ, Durgam GG, Miller DD, Jiang G, Prestwich GD, Tigyi G, Siess W.
    Platelets; 2008 Sep 09; 19(6):415-27. PubMed ID: 18925509
    [Abstract] [Full Text] [Related]

  • 16. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist.
    Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):4069-74. PubMed ID: 15225728
    [Abstract] [Full Text] [Related]

  • 17. Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.
    Xu Y, Tanaka M, Arai H, Aoki J, Prestwich GD.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5323-8. PubMed ID: 15454220
    [Abstract] [Full Text] [Related]

  • 18. Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.
    Qian L, Xu Y, Arai H, Aoki J, McIntyre TM, Prestwich GD.
    Org Lett; 2003 Nov 27; 5(24):4685-8. PubMed ID: 14627415
    [Abstract] [Full Text] [Related]

  • 19. Involvement of aberrant DNA methylation on reduced expression of lysophosphatidic acid receptor-1 gene in rat tumor cell lines.
    Tsujiuchi T, Shimizu K, Onishi M, Sugata E, Fujii H, Mori T, Honoki K, Fukushima N.
    Biochem Biophys Res Commun; 2006 Oct 27; 349(3):1151-5. PubMed ID: 16970915
    [Abstract] [Full Text] [Related]

  • 20. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
    Hasegawa Y, Erickson JR, Goddard GJ, Yu S, Liu S, Cheng KW, Eder A, Bandoh K, Aoki J, Jarosz R, Schrier AD, Lynch KR, Mills GB, Fang X.
    J Biol Chem; 2003 Apr 04; 278(14):11962-9. PubMed ID: 12554733
    [Abstract] [Full Text] [Related]

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