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133 related items for PubMed ID: 16940412

  • 1. Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.
    Dabydeen DA, Burnett JC, Bai R, Verdier-Pinard P, Hickford SJ, Pettit GR, Blunt JW, Munro MH, Gussio R, Hamel E.
    Mol Pharmacol; 2006 Dec; 70(6):1866-75. PubMed ID: 16940412
    [Abstract] [Full Text] [Related]

  • 2. In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.
    Towle MJ, Salvato KA, Budrow J, Wels BF, Kuznetsov G, Aalfs KK, Welsh S, Zheng W, Seletsky BM, Palme MH, Habgood GJ, Singer LA, Dipietro LV, Wang Y, Chen JJ, Quincy DA, Davis A, Yoshimatsu K, Kishi Y, Yu MJ, Littlefield BA.
    Cancer Res; 2001 Feb 01; 61(3):1013-21. PubMed ID: 11221827
    [Abstract] [Full Text] [Related]

  • 3. Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation.
    Alday PH, Correia JJ.
    Biochemistry; 2009 Aug 25; 48(33):7927-38. PubMed ID: 19586046
    [Abstract] [Full Text] [Related]

  • 4. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
    Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E.
    J Biol Chem; 1991 Aug 25; 266(24):15882-9. PubMed ID: 1874739
    [Abstract] [Full Text] [Related]

  • 5. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.
    Biochemistry; 1995 Aug 01; 34(30):9714-21. PubMed ID: 7626642
    [Abstract] [Full Text] [Related]

  • 6. Macrocyclic ketone analogues of halichondrin B.
    Zheng W, Seletsky BM, Palme MH, Lydon PJ, Singer LA, Chase CE, Lemelin CA, Shen Y, Davis H, Tremblay L, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ.
    Bioorg Med Chem Lett; 2004 Nov 15; 14(22):5551-4. PubMed ID: 15482922
    [Abstract] [Full Text] [Related]

  • 7. Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389.
    Kuznetsov G, Towle MJ, Cheng H, Kawamura T, TenDyke K, Liu D, Kishi Y, Yu MJ, Littlefield BA.
    Cancer Res; 2004 Aug 15; 64(16):5760-6. PubMed ID: 15313917
    [Abstract] [Full Text] [Related]

  • 8. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
    Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.
    Mol Pharmacol; 1993 Oct 15; 44(4):757-66. PubMed ID: 8232226
    [Abstract] [Full Text] [Related]

  • 9. Interactions of halichondrin B and eribulin with tubulin.
    Bai R, Nguyen TL, Burnett JC, Atasoylu O, Munro MH, Pettit GR, Smith AB, Gussio R, Hamel E.
    J Chem Inf Model; 2011 Jun 27; 51(6):1393-404. PubMed ID: 21539396
    [Abstract] [Full Text] [Related]

  • 10. Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.
    Ludueña RF, Roach MC, Prasad V, Pettit GR.
    Biochem Pharmacol; 1993 Jan 26; 45(2):421-7. PubMed ID: 8435093
    [Abstract] [Full Text] [Related]

  • 11. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth.
    Jordan MA, Kamath K, Manna T, Okouneva T, Miller HP, Davis C, Littlefield BA, Wilson L.
    Mol Cancer Ther; 2005 Jul 26; 4(7):1086-95. PubMed ID: 16020666
    [Abstract] [Full Text] [Related]

  • 12. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
    Bai RL, Pettit GR, Hamel E.
    J Biol Chem; 1990 Oct 05; 265(28):17141-9. PubMed ID: 2211617
    [Abstract] [Full Text] [Related]

  • 13. Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability.
    Smith JA, Wilson L, Azarenko O, Zhu X, Lewis BM, Littlefield BA, Jordan MA.
    Biochemistry; 2010 Feb 16; 49(6):1331-7. PubMed ID: 20030375
    [Abstract] [Full Text] [Related]

  • 14. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
    Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E.
    Eur J Biochem; 2003 Sep 16; 270(18):3822-8. PubMed ID: 12950266
    [Abstract] [Full Text] [Related]

  • 15. Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer.
    Newman S.
    Curr Opin Investig Drugs; 2007 Dec 16; 8(12):1057-66. PubMed ID: 18058576
    [Abstract] [Full Text] [Related]

  • 16. Effects of antimitotic agents on tubulin-nucleotide interactions.
    Correia JJ.
    Pharmacol Ther; 1991 Nov 16; 52(2):127-47. PubMed ID: 1818332
    [Abstract] [Full Text] [Related]

  • 17. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.
    Hamel E.
    Pharmacol Ther; 1992 Nov 16; 55(1):31-51. PubMed ID: 1287674
    [Abstract] [Full Text] [Related]

  • 18. Immunomodulatory Effects of Halichondrin Isolated from Marine Sponges and Its Synthetic Analogs in Oncological Applications.
    Dissanayake DS, Nagahawatta DP, Lee JS, Jeon YJ.
    Mar Drugs; 2024 Sep 20; 22(9):. PubMed ID: 39330307
    [Abstract] [Full Text] [Related]

  • 19. The interaction of spongistatin 1 with tubulin.
    Bai R, Smith AB, Pettit GR, Hamel E.
    Arch Biochem Biophys; 2022 Sep 30; 727():109296. PubMed ID: 35594923
    [Abstract] [Full Text] [Related]

  • 20. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
    Bai R, Pettit GR, Hamel E.
    Biochem Pharmacol; 1990 Jun 15; 39(12):1941-9. PubMed ID: 2353935
    [Abstract] [Full Text] [Related]

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