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PUBMED FOR HANDHELDS

Journal Abstract Search

146 related items for PubMed ID: 16970392

  • 1. Identification of a novel 4-aminomethylpiperidine class of M3 muscarinic receptor antagonists and structural insight into their M3 selectivity.
    Sagara Y, Sagara T, Uchiyama M, Otsuki S, Kimura T, Fujikawa T, Noguchi K, Ohtake N.
    J Med Chem; 2006 Sep 21; 49(19):5653-63. PubMed ID: 16970392
    [Abstract] [Full Text] [Related]

  • 2. Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).
    Peretto I, Forlani R, Fossati C, Giardina GA, Giardini A, Guala M, La Porta E, Petrillo P, Radaelli S, Radice L, Raveglia LF, Santoro E, Scudellaro R, Scarpitta F, Bigogno C, Misiano P, Dondio GM, Rizzi A, Armani E, Amari G, Civelli M, Villetti G, Patacchini R, Bergamaschi M, Delcanale M, Salcedo C, Fernández AG, Imbimbo BP.
    J Med Chem; 2007 Apr 05; 50(7):1571-83. PubMed ID: 17352462
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  • 3. Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.
    Sagara Y, Sagara T, Mase T, Kimura T, Numazawa T, Fujikawa T, Noguchi K, Ohtake N.
    J Med Chem; 2002 Feb 14; 45(4):984-7. PubMed ID: 11831911
    [Abstract] [Full Text] [Related]

  • 4. Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists.
    Lainé DI, McCleland B, Thomas S, Neipp C, Underwood B, Dufour J, Widdowson KL, Palovich MR, Blaney FE, Foley JJ, Webb EF, Luttmann MA, Burman M, Belmonte K, Salmon M.
    J Med Chem; 2009 Apr 23; 52(8):2493-505. PubMed ID: 19317446
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  • 5. Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).
    Peretto I, Fossati C, Giardina GA, Giardini A, Guala M, La Porta E, Petrillo P, Radaelli S, Radice L, Raveglia LF, Santoro E, Scudellaro R, Scarpitta F, Cerri A, Menegon S, Dondio GM, Rizzi A, Armani E, Amari G, Civelli M, Villetti G, Patacchini R, Bergamaschi M, Bassani F, Delcanale M, Imbimbo BP.
    J Med Chem; 2007 Apr 05; 50(7):1693-7. PubMed ID: 17352463
    [Abstract] [Full Text] [Related]

  • 6. In vivo demonstration of M3 muscarinic receptor subtype selectivity of darifenacin in mice.
    Yamada S, Maruyama S, Takagi Y, Uchida S, Oki T.
    Life Sci; 2006 Dec 14; 80(2):127-32. PubMed ID: 16996089
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  • 7. M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines.
    Budzik B, Wang Y, Shi D, Wang F, Xie H, Wan Z, Zhu C, Foley JJ, Nuthulaganti P, Kallal LA, Sarau HM, Morrow DM, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Laine DI, Jin J.
    Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1686-90. PubMed ID: 19243945
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  • 9. Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist.
    McNamara A, Pulido-Rios MT, Sweazey S, Obedencio GP, Thibodeaux H, Renner T, Armstrong SR, Steinfeld T, Hughes AD, Wilson RD, Jasper JR, Mammen M, Hegde SS.
    Eur J Pharmacol; 2009 Mar 01; 605(1-3):145-52. PubMed ID: 19168050
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  • 12. Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
    Le Bourdonnec B, Goodman AJ, Michaut M, Ye HF, Graczyk TM, Belanger S, Herbertz T, Yap GP, DeHaven RN, Dolle RE.
    J Med Chem; 2006 Dec 14; 49(25):7278-89. PubMed ID: 17149858
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  • 13. Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.
    Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Bedini A, Fazio N, Spampinato S.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2972-6. PubMed ID: 18395442
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  • 15. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
    Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3072-7. PubMed ID: 19403308
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  • 18. Lead generation using pharmacophore mapping and three-dimensional database searching: application to muscarinic M(3) receptor antagonists.
    Marriott DP, Dougall IG, Meghani P, Liu YJ, Flower DR.
    J Med Chem; 1999 Aug 26; 42(17):3210-6. PubMed ID: 10464008
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  • 19. Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.
    Naito R, Yonetoku Y, Okamoto Y, Toyoshima A, Ikeda K, Takeuchi M.
    J Med Chem; 2005 Oct 20; 48(21):6597-606. PubMed ID: 16220976
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