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387 related items for PubMed ID: 16970927

  • 1. Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
    Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL.
    Biochem Pharmacol; 2006 Dec 15; 72(12):1714-23. PubMed ID: 16970927
    [Abstract] [Full Text] [Related]

  • 2. Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.
    Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.
    Int J Cancer; 2006 Feb 15; 118(4):857-68. PubMed ID: 16152627
    [Abstract] [Full Text] [Related]

  • 3. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.
    Oncogene; 2001 May 24; 20(23):2927-36. PubMed ID: 11420705
    [Abstract] [Full Text] [Related]

  • 4. Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells.
    Zhang J, Hsu B A JC, Kinseth B A MA, Bjeldanes LF, Firestone GL.
    Cancer; 2003 Dec 01; 98(11):2511-20. PubMed ID: 14635088
    [Abstract] [Full Text] [Related]

  • 5. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
    Hsu JC, Zhang J, Dev A, Wing A, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2005 Nov 01; 26(11):1896-904. PubMed ID: 15958518
    [Abstract] [Full Text] [Related]

  • 6. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    Firestone GL, Bjeldanes LF.
    J Nutr; 2003 Jul 01; 133(7 Suppl):2448S-2455S. PubMed ID: 12840223
    [Abstract] [Full Text] [Related]

  • 7. Indole-3-carbinol stimulates transcription of the interferon gamma receptor 1 gene and augments interferon responsiveness in human breast cancer cells.
    Chatterji U, Riby JE, Taniguchi T, Bjeldanes EL, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2004 Jul 01; 25(7):1119-28. PubMed ID: 14988219
    [Abstract] [Full Text] [Related]

  • 8. Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.
    Choi HS, Cho MC, Lee HG, Yoon DY.
    Food Chem Toxicol; 2010 Mar 01; 48(3):883-90. PubMed ID: 20060030
    [Abstract] [Full Text] [Related]

  • 9. Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
    Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL.
    Carcinogenesis; 2011 Sep 01; 32(9):1315-23. PubMed ID: 21693539
    [Abstract] [Full Text] [Related]

  • 10. Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
    Chowdhury IH, Farhadi A, Wang XF, Robb ML, Birx DL, Kim JH.
    Int J Cancer; 2003 Nov 20; 107(4):603-11. PubMed ID: 14520699
    [Abstract] [Full Text] [Related]

  • 11. The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line.
    Matsui TA, Sowa Y, Murata H, Takagi K, Nakanishi R, Aoki S, Yoshikawa M, Kobayashi M, Sakabe T, Kubo T, Sakai T.
    Int J Oncol; 2007 Oct 20; 31(4):915-22. PubMed ID: 17786325
    [Abstract] [Full Text] [Related]

  • 12. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.
    Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, Firestone GL.
    J Biol Chem; 1998 Feb 13; 273(7):3838-47. PubMed ID: 9461564
    [Abstract] [Full Text] [Related]

  • 13. Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer.
    Yu SY, Liao CH, Chien MH, Tsai TY, Lin JK, Weng MS.
    J Agric Food Chem; 2014 Mar 05; 62(9):2085-95. PubMed ID: 24533688
    [Abstract] [Full Text] [Related]

  • 14. Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).
    Zhao Y, Lu S, Wu L, Chai G, Wang H, Chen Y, Sun J, Yu Y, Zhou W, Zheng Q, Wu M, Otterson GA, Zhu WG.
    Mol Cell Biol; 2006 Apr 05; 26(7):2782-90. PubMed ID: 16537920
    [Abstract] [Full Text] [Related]

  • 15. Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.
    Herman-Antosiewicz A, Xiao H, Lew KL, Singh SV.
    Mol Cancer Ther; 2007 May 05; 6(5):1673-81. PubMed ID: 17513615
    [Abstract] [Full Text] [Related]

  • 16. Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals.
    Wang TT, Schoene NW, Milner JA, Kim YS.
    Mol Carcinog; 2012 Mar 05; 51(3):244-56. PubMed ID: 21520295
    [Abstract] [Full Text] [Related]

  • 17. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    Cram EJ, Liu BD, Bjeldanes LF, Firestone GL.
    J Biol Chem; 2001 Jun 22; 276(25):22332-40. PubMed ID: 11297539
    [Abstract] [Full Text] [Related]

  • 18. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity.
    Hahm ER, Singh SV.
    Mol Cancer Ther; 2007 Oct 22; 6(10):2686-95. PubMed ID: 17938262
    [Abstract] [Full Text] [Related]

  • 19. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.
    Facchinetti MM, De Siervi A, Toskos D, Senderowicz AM.
    Cancer Res; 2004 May 15; 64(10):3629-37. PubMed ID: 15150122
    [Abstract] [Full Text] [Related]

  • 20. Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate.
    Hastak K, Agarwal MK, Mukhtar H, Agarwal ML.
    FASEB J; 2005 May 15; 19(7):789-91. PubMed ID: 15764647
    [Abstract] [Full Text] [Related]

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