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Journal Abstract Search

154 related items for PubMed ID: 16979587

  • 1. Abeta 11-40/42 production without gamma-secretase epsilon-site cleavage.
    Kume H, Kametani F.
    Biochem Biophys Res Commun; 2006 Nov 03; 349(4):1356-60. PubMed ID: 16979587
    [Abstract] [Full Text] [Related]

  • 2. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H, Maruyama K, Kametani F.
    Int J Mol Med; 2004 Jan 03; 13(1):121-5. PubMed ID: 14654982
    [Abstract] [Full Text] [Related]

  • 3. Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting.
    Kametani F.
    FEBS Lett; 2004 Jul 16; 570(1-3):73-6. PubMed ID: 15251442
    [Abstract] [Full Text] [Related]

  • 4. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S, Sunyach C, Checler F.
    J Neurochem; 2006 May 16; 97(3):807-17. PubMed ID: 16524370
    [Abstract] [Full Text] [Related]

  • 5. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.
    Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y.
    FEBS Lett; 2005 May 23; 579(13):2907-12. PubMed ID: 15890346
    [Abstract] [Full Text] [Related]

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  • 8. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.
    J Neurosci Res; 2003 Nov 01; 74(3):378-85. PubMed ID: 14598314
    [Abstract] [Full Text] [Related]

  • 9. gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting.
    Kume H, Sekijima Y, Maruyama K, Kametani F.
    Int J Mol Med; 2003 Jul 01; 12(1):57-60. PubMed ID: 12792809
    [Abstract] [Full Text] [Related]

  • 10. DNA damage-inducing agents elicit gamma-secretase activation mediated by oxidative stress.
    Jin SM, Cho HJ, Jung ES, Shim MY, Mook-Jung I.
    Cell Death Differ; 2008 Sep 01; 15(9):1375-84. PubMed ID: 18421302
    [Abstract] [Full Text] [Related]

  • 11. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta.
    Bakshi P, Jin C, Broutin P, Berhane B, Reed J, Mullan M.
    Bioorg Med Chem; 2009 Dec 01; 17(23):8102-12. PubMed ID: 19853461
    [Abstract] [Full Text] [Related]

  • 12. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
    Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU.
    J Neurochem; 2009 Dec 01; 111(6):1369-82. PubMed ID: 19804379
    [Abstract] [Full Text] [Related]

  • 13. Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.
    Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
    Neurodegener Dis; 2008 Dec 01; 5(3-4):160-2. PubMed ID: 18322378
    [Abstract] [Full Text] [Related]

  • 14. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
    Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE.
    J Neurochem; 2005 Oct 01; 95(2):446-56. PubMed ID: 16086682
    [Abstract] [Full Text] [Related]

  • 15. Epsilon-secretase: reduction of amyloid precursor protein epsilon-site cleavage in Alzheimer's disease.
    Kametani F.
    Curr Alzheimer Res; 2008 Apr 01; 5(2):165-71. PubMed ID: 18393801
    [Abstract] [Full Text] [Related]

  • 16. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
    Knappenberger KS, Tian G, Ye X, Sobotka-Briner C, Ghanekar SV, Greenberg BD, Scott CW.
    Biochemistry; 2004 May 25; 43(20):6208-18. PubMed ID: 15147205
    [Abstract] [Full Text] [Related]

  • 17. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ, Octave JN.
    J Neurosci Res; 2006 Nov 01; 84(6):1311-22. PubMed ID: 16941495
    [Abstract] [Full Text] [Related]

  • 18. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.
    J Neurochem; 2006 Jan 01; 96(1):118-25. PubMed ID: 16300640
    [Abstract] [Full Text] [Related]

  • 19. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
    Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE.
    Neurobiol Dis; 2002 Feb 01; 9(1):11-23. PubMed ID: 11848681
    [Abstract] [Full Text] [Related]

  • 20. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
    Gamerdinger M, Clement AB, Behl C.
    Neuropharmacology; 2008 May 01; 54(6):998-1005. PubMed ID: 18359496
    [Abstract] [Full Text] [Related]

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