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Journal Abstract Search

131 related items for PubMed ID: 16989816

  • 1. Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.
    Li Y, Lu W, He X, Bu G.
    FEBS Lett; 2006 Oct 02; 580(22):5423-8. PubMed ID: 16989816
    [Abstract] [Full Text] [Related]

  • 2. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
    Lu W, Liu CC, Thottassery JV, Bu G, Li Y.
    Biochemistry; 2010 Jun 08; 49(22):4635-43. PubMed ID: 20446724
    [Abstract] [Full Text] [Related]

  • 3. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
    Liu CC, Pearson C, Bu G.
    J Biol Chem; 2009 May 29; 284(22):15299-307. PubMed ID: 19339249
    [Abstract] [Full Text] [Related]

  • 4. Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
    Koduri V, Blacklow SC.
    Biochemistry; 2007 Jun 05; 46(22):6570-7. PubMed ID: 17488095
    [Abstract] [Full Text] [Related]

  • 5. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
    Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G.
    J Cell Sci; 2005 Nov 15; 118(Pt 22):5305-14. PubMed ID: 16263759
    [Abstract] [Full Text] [Related]

  • 6. The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.
    Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y.
    PLoS One; 2013 Nov 15; 8(2):e58102. PubMed ID: 23469146
    [Abstract] [Full Text] [Related]

  • 7. Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.
    Lin C, Lu W, Zhai L, Bethea T, Berry K, Qu Z, Waud WR, Li Y.
    FEBS Lett; 2011 Oct 03; 585(19):3120-5. PubMed ID: 21907199
    [Abstract] [Full Text] [Related]

  • 8. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy.
    Liu CC, Prior J, Piwnica-Worms D, Bu G.
    Proc Natl Acad Sci U S A; 2010 Mar 16; 107(11):5136-41. PubMed ID: 20194742
    [Abstract] [Full Text] [Related]

  • 9. Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.
    Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K.
    J Bone Miner Res; 2008 Oct 16; 23(10):1661-71. PubMed ID: 18505367
    [Abstract] [Full Text] [Related]

  • 10. Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
    MacDonald BT, Yokota C, Tamai K, Zeng X, He X.
    J Biol Chem; 2008 Jun 06; 283(23):16115-23. PubMed ID: 18362152
    [Abstract] [Full Text] [Related]

  • 11. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.
    Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M.
    PLoS One; 2010 Sep 13; 5(9):e12682. PubMed ID: 20856934
    [Abstract] [Full Text] [Related]

  • 12. Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.
    Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC.
    Cell; 2003 Feb 07; 112(3):355-67. PubMed ID: 12581525
    [Abstract] [Full Text] [Related]

  • 13. Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta.
    Moosa S, Yamamoto GL, Garbes L, Keupp K, Beleza-Meireles A, Moreno CA, Valadares ER, de Sousa SB, Maia S, Saraiva J, Honjo RS, Kim CA, Cabral de Menezes H, Lausch E, Lorini PV, Lamounier A, Carniero TCB, Giunta C, Rohrbach M, Janner M, Semler O, Beleggia F, Li Y, Yigit G, Reintjes N, Altmüller J, Nürnberg P, Cavalcanti DP, Zabel B, Warman ML, Bertola DR, Wollnik B, Netzer C.
    Am J Hum Genet; 2019 Oct 03; 105(4):836-843. PubMed ID: 31564437
    [Abstract] [Full Text] [Related]

  • 14. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.
    Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J.
    Structure; 2011 Mar 09; 19(3):313-23. PubMed ID: 21397183
    [Abstract] [Full Text] [Related]

  • 15. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis.
    Zhang J, Li Y, Liu Q, Lu W, Bu G.
    Oncogene; 2010 Jan 28; 29(4):539-49. PubMed ID: 19881541
    [Abstract] [Full Text] [Related]

  • 16. Functional interactions between the LRP6 WNT co-receptor and folate supplementation.
    Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME.
    Hum Mol Genet; 2010 Dec 01; 19(23):4560-72. PubMed ID: 20843827
    [Abstract] [Full Text] [Related]

  • 17. The first propeller domain of LRP6 regulates sensitivity to DKK1.
    Binnerts ME, Tomasevic N, Bright JM, Leung J, Ahn VE, Kim KA, Zhan X, Liu S, Yonkovich S, Williams J, Zhou M, Gros D, Dixon M, Korver W, Weis WI, Abo A.
    Mol Biol Cell; 2009 Aug 01; 20(15):3552-60. PubMed ID: 19477926
    [Abstract] [Full Text] [Related]

  • 18. A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).
    Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV.
    J Cell Biochem; 2009 Dec 01; 108(5):1066-75. PubMed ID: 19746449
    [Abstract] [Full Text] [Related]

  • 19. Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.
    Ma J, Lu W, Chen D, Xu B, Li Y.
    J Cell Biochem; 2017 Sep 01; 118(9):2968-2976. PubMed ID: 28247948
    [Abstract] [Full Text] [Related]

  • 20. Functional analysis of disease-associated polymorphism LRP5.Q89R.
    Mao W, Wordinger RJ, Clark AF.
    Mol Vis; 2011 Apr 08; 17():894-902. PubMed ID: 21528003
    [Abstract] [Full Text] [Related]

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