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140 related items for PubMed ID: 17065199

  • 1. Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system.
    Steiner C, Peters WH, Gallagher EP, Magee P, Rowland I, Pool-Zobel BL.
    Carcinogenesis; 2007 Mar; 28(3):738-48. PubMed ID: 17065199
    [Abstract] [Full Text] [Related]

  • 2. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase.
    Hu X, Herzog C, Zimniak P, Singh SV.
    Cancer Res; 1999 May 15; 59(10):2358-62. PubMed ID: 10344744
    [Abstract] [Full Text] [Related]

  • 3. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1.
    Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ.
    Carcinogenesis; 2007 Jan 15; 28(1):207-14. PubMed ID: 16885195
    [Abstract] [Full Text] [Related]

  • 4. Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate.
    Knoll N, Ruhe C, Veeriah S, Sauer J, Glei M, Gallagher EP, Pool-Zobel BL.
    Toxicol Sci; 2005 Jul 15; 86(1):27-35. PubMed ID: 15829614
    [Abstract] [Full Text] [Related]

  • 5. Overexpression of stably transfected human glutathione S-transferase P1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells.
    Fields WR, Morrow CS, Doss AJ, Sundberg K, Jernström B, Townsend AJ.
    Mol Pharmacol; 1998 Aug 15; 54(2):298-304. PubMed ID: 9687571
    [Abstract] [Full Text] [Related]

  • 6. Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.
    Townsend AJ, Fields WR, Haynes RL, Doss AJ, Li Y, Doehmer J, Morrow CS.
    Chem Biol Interact; 1998 Apr 24; 111-112():389-407. PubMed ID: 9679569
    [Abstract] [Full Text] [Related]

  • 7. Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.
    Hu X, O'Donnell R, Srivastava SK, Xia H, Zimniak P, Nanduri B, Bleicher RJ, Awasthi S, Awasthi YC, Ji X, Singh SV.
    Biochem Biophys Res Commun; 1997 Jun 18; 235(2):424-8. PubMed ID: 9199210
    [Abstract] [Full Text] [Related]

  • 8. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1.
    Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ.
    Toxicol Sci; 2007 Sep 18; 99(1):51-7. PubMed ID: 17525473
    [Abstract] [Full Text] [Related]

  • 9. Butyrate induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal.
    Ebert MN, Beyer-Sehlmeyer G, Liegibel UM, Kautenburger T, Becker TW, Pool-Zobel BL.
    Nutr Cancer; 2001 Sep 18; 41(1-2):156-64. PubMed ID: 12094619
    [Abstract] [Full Text] [Related]

  • 10. Expression of hGSTP1 alleles in human lung and catalytic activity of the native protein variants towards 1-chloro-2,4-dinitrobenzene, 4-vinylpyridine and (+)-anti benzo[a]pyrene-7,8-diol-9,10-oxide.
    Coles B, Yang M, Lang NP, Kadlubar FF.
    Cancer Lett; 2000 Aug 11; 156(2):167-75. PubMed ID: 10880766
    [Abstract] [Full Text] [Related]

  • 11. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
    Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ.
    Chem Biol Interact; 2009 May 15; 179(2-3):240-6. PubMed ID: 19330882
    [Abstract] [Full Text] [Related]

  • 12. Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene.
    Leyland-Jones BR, Townsend AJ, Tu CP, Cowan KH, Goldsmith ME.
    Cancer Res; 1991 Jan 15; 51(2):587-94. PubMed ID: 1985777
    [Abstract] [Full Text] [Related]

  • 13. Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress.
    Raschke M, Rowland IR, Magee PJ, Pool-Zobel BL.
    Carcinogenesis; 2006 Nov 15; 27(11):2322-30. PubMed ID: 16774941
    [Abstract] [Full Text] [Related]

  • 14. Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines.
    Townsend AJ, Kabler SL, Doehmer J, Morrow CS.
    Toxicology; 2002 Dec 27; 181-182():265-9. PubMed ID: 12505323
    [Abstract] [Full Text] [Related]

  • 15. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.
    Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC.
    Carcinogenesis; 2005 Oct 27; 26(10):1793-803. PubMed ID: 15905199
    [Abstract] [Full Text] [Related]

  • 16. Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials.
    Steinkellner H, Hoelzl C, Uhl M, Cavin C, Haidinger G, Gsur A, Schmid R, Kundi M, Bichler J, Knasmüller S.
    Mutat Res; 2005 Dec 11; 591(1-2):264-75. PubMed ID: 16099480
    [Abstract] [Full Text] [Related]

  • 17. Comparison of the mRNA sequences for Pi class glutathione transferases in different hamster species and the corresponding enzyme activities with anti-benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide.
    Swedmark S, Jernström B, Jenssen D.
    Biochem J; 1996 Sep 01; 318 ( Pt 2)(Pt 2):533-8. PubMed ID: 8809043
    [Abstract] [Full Text] [Related]

  • 18. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression.
    Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ.
    Toxicol Lett; 2008 Dec 15; 183(1-3):99-104. PubMed ID: 18992797
    [Abstract] [Full Text] [Related]

  • 19. Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damage.
    Srivastava SK, Watkins SC, Schuetz E, Singh SV.
    Mol Carcinog; 2002 Mar 15; 33(3):156-62. PubMed ID: 11870881
    [Abstract] [Full Text] [Related]

  • 20. Factors influencing elevation of intracellular Ca2+ in the MCF-10A human mammary epithelial cell line by carcinogenic polycyclic aromatic hydrocarbons.
    Tannheimer SL, Lauer FT, Lane J, Burchiel SW.
    Mol Carcinog; 1999 May 15; 25(1):48-54. PubMed ID: 10331744
    [Abstract] [Full Text] [Related]

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