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827 related items for PubMed ID: 17068144

  • 1. Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.
    Endocrinology; 2007 Feb; 148(2):512-29. PubMed ID: 17068144
    [Abstract] [Full Text] [Related]

  • 2. Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function.
    Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P, Arnoletti E, Ghè C, Volante M, Papotti M, Muccioli G, Ghigo E.
    Diabetes; 2008 Apr; 57(4):967-79. PubMed ID: 18162507
    [Abstract] [Full Text] [Related]

  • 3. The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways.
    Favaro E, Granata R, Miceli I, Baragli A, Settanni F, Cavallo Perin P, Ghigo E, Camussi G, Zanone MM.
    Diabetologia; 2012 Apr; 55(4):1058-70. PubMed ID: 22231124
    [Abstract] [Full Text] [Related]

  • 4. Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells.
    Chung H, Seo S, Moon M, Park S.
    J Endocrinol; 2008 Sep; 198(3):511-21. PubMed ID: 18541646
    [Abstract] [Full Text] [Related]

  • 5. Unacylated as well as acylated ghrelin promotes cell survival and inhibit apoptosis in HIT-T15 pancreatic beta-cells.
    Granata R, Settanni F, Trovato L, Destefanis S, Gallo D, Martinetti M, Ghigo E, Muccioli G.
    J Endocrinol Invest; 2006 Oct; 29(9):RC19-22. PubMed ID: 17114904
    [Abstract] [Full Text] [Related]

  • 6. AG and UAG induce β-casein expression via activation of ERK1/2 and AKT pathways.
    Li S, Liu J, Lv Q, Zhang C, Xu S, Yang D, Huang B, Zeng Y, Gao Y, Wang W.
    J Mol Endocrinol; 2016 Apr; 56(3):213-25. PubMed ID: 26873999
    [Abstract] [Full Text] [Related]

  • 7. Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
    Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G.
    Biochim Biophys Acta; 2011 Jun; 1811(6):386-96. PubMed ID: 21435395
    [Abstract] [Full Text] [Related]

  • 8. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas.
    Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E.
    J Mol Endocrinol; 2010 Sep; 45(3):107-18. PubMed ID: 20595321
    [Abstract] [Full Text] [Related]

  • 9. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.
    Gauna C, Delhanty PJ, van Aken MO, Janssen JA, Themmen AP, Hofland LJ, Culler M, Broglio F, Ghigo E, van der Lely AJ.
    Mol Cell Endocrinol; 2006 Jun 07; 251(1-2):103-11. PubMed ID: 16647196
    [Abstract] [Full Text] [Related]

  • 10. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.
    Granata R, Volante M, Settanni F, Gauna C, Ghé C, Annunziata M, Deidda B, Gesmundo I, Abribat T, van der Lely AJ, Muccioli G, Ghigo E, Papotti M.
    J Mol Endocrinol; 2010 Jul 07; 45(1):9-17. PubMed ID: 20382773
    [Abstract] [Full Text] [Related]

  • 11. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.
    Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, Van Der Lely AJ, Ghigo E.
    J Clin Endocrinol Metab; 2004 Jun 07; 89(6):3062-5. PubMed ID: 15181099
    [Abstract] [Full Text] [Related]

  • 12. RFamide peptides 43RFa and 26RFa both promote survival of pancreatic β-cells and human pancreatic islets but exert opposite effects on insulin secretion.
    Granata R, Settanni F, Trovato L, Gallo D, Gesmundo I, Nano R, Gallo MP, Bergandi L, Volante M, Alloatti G, Piemonti L, Leprince J, Papotti M, Vaudry H, Ong H, Ghigo E.
    Diabetes; 2014 Jul 07; 63(7):2380-93. PubMed ID: 24622796
    [Abstract] [Full Text] [Related]

  • 13. Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a.
    Delhanty PJ, van der Eerden BC, van der Velde M, Gauna C, Pols HA, Jahr H, Chiba H, van der Lely AJ, van Leeuwen JP.
    J Endocrinol; 2006 Jan 07; 188(1):37-47. PubMed ID: 16394173
    [Abstract] [Full Text] [Related]

  • 14. Pancreatic-β-cell survival and proliferation are promoted by protein kinase G type Iα and downstream regulation of AKT/FOXO1.
    Wong JC, Vo V, Gorjala P, Fiscus RR.
    Diab Vasc Dis Res; 2017 Sep 07; 14(5):434-449. PubMed ID: 28631500
    [Abstract] [Full Text] [Related]

  • 15. The role of phosphoinositide 3-kinase/Akt signaling in low-dose mercury-induced mouse pancreatic beta-cell dysfunction in vitro and in vivo.
    Chen YW, Huang CF, Tsai KS, Yang RS, Yen CC, Yang CY, Lin-Shiau SY, Liu SH.
    Diabetes; 2006 Jun 07; 55(6):1614-24. PubMed ID: 16731823
    [Abstract] [Full Text] [Related]

  • 16. Products of the ghrelin gene, the pancreatic β-cell and the adipocyte.
    Granata R, Ghigo E.
    Endocr Dev; 2013 Jun 07; 25():144-56. PubMed ID: 23652400
    [Abstract] [Full Text] [Related]

  • 17. Ghrelin inhibit cell apoptosis in pancreatic beta cell line HIT-T15 via mitogen-activated protein kinase/phosphoinositide 3-kinase pathways.
    Zhang Y, Ying B, Shi L, Fan H, Yang D, Xu D, Wei Y, Hu X, Zhang Y, Zhang X, Wang T, Liu D, Dou L, Chen G, Jiang F, Wen F.
    Toxicology; 2007 Jul 31; 237(1-3):194-202. PubMed ID: 17602820
    [Abstract] [Full Text] [Related]

  • 18. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.
    Edén D, Siegbahn A, Mokhtari D.
    Diabetologia; 2015 Nov 31; 58(11):2563-72. PubMed ID: 26271343
    [Abstract] [Full Text] [Related]

  • 19. Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling.
    Trümper A, Trümper K, Trusheim H, Arnold R, Göke B, Hörsch D.
    Mol Endocrinol; 2001 Sep 31; 15(9):1559-70. PubMed ID: 11518806
    [Abstract] [Full Text] [Related]

  • 20. Gastric bypass surgery may improve beta cell apoptosis with ghrelin overexpression in patients with BMI ≥ 32.5 kg/m(2.).
    Yang J, Feng X, Zhong S, Wang Y, Liu J.
    Obes Surg; 2014 Apr 31; 24(4):561-71. PubMed ID: 24293163
    [Abstract] [Full Text] [Related]

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