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Journal Abstract Search

147 related items for PubMed ID: 17088480

  • 1. Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.
    Yang W, Sun Y, Phadke A, Deshpande M, Huang M.
    Antimicrob Agents Chemother; 2007 Jan; 51(1):338-42. PubMed ID: 17088480
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  • 2. Studying HCV RNA synthesis in vitro with replication complexes.
    Yang W, Huang M.
    Methods Mol Biol; 2009 Jan; 510():177-84. PubMed ID: 19009261
    [Abstract] [Full Text] [Related]

  • 3. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
    McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G.
    Nucleic Acids Res; 2004 Jan; 32(2):422-31. PubMed ID: 14739234
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  • 4. Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA.
    Karam P, Powdrill MH, Liu HW, Vasquez C, Mah W, Bernatchez J, Götte M, Cosa G.
    J Biol Chem; 2014 May 16; 289(20):14399-411. PubMed ID: 24692556
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  • 5. A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A.
    Ranjith-Kumar CT, Wen Y, Baxter N, Bhardwaj K, Cheng Kao C.
    PLoS One; 2011 May 16; 6(7):e22575. PubMed ID: 21799903
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  • 7. In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus.
    Bilello JP, Lallos LB, McCarville JF, La Colla M, Serra I, Chapron C, Gillum JM, Pierra C, Standring DN, Seifer M.
    Antimicrob Agents Chemother; 2014 Aug 16; 58(8):4431-42. PubMed ID: 24867983
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  • 8. Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.
    Jin G, Lee S, Choi M, Son S, Kim GW, Oh JW, Lee C, Lee K.
    Eur J Med Chem; 2014 Mar 21; 75():413-25. PubMed ID: 24561671
    [Abstract] [Full Text] [Related]

  • 9. Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells.
    Choi HB, Kim YG, Oh JW.
    Exp Mol Med; 2003 Dec 31; 35(6):475-85. PubMed ID: 14749524
    [Abstract] [Full Text] [Related]

  • 10. A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template.
    Ferrari E, Huang HC.
    Methods Mol Biol; 2013 Dec 31; 1030():81-92. PubMed ID: 23821261
    [Abstract] [Full Text] [Related]

  • 11. Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
    Liu Y, Jiang WW, Pratt J, Rockway T, Harris K, Vasavanonda S, Tripathi R, Pithawalla R, Kati WM.
    Biochemistry; 2006 Sep 26; 45(38):11312-23. PubMed ID: 16981691
    [Abstract] [Full Text] [Related]

  • 12. Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template.
    Oh JW, Sheu GT, Lai MM.
    J Biol Chem; 2000 Jun 09; 275(23):17710-7. PubMed ID: 10749880
    [Abstract] [Full Text] [Related]

  • 13. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors.
    Das D, Hong J, Chen SH, Wang G, Beigelman L, Seiwert SD, Buckman BO.
    Bioorg Med Chem; 2011 Aug 15; 19(16):4690-703. PubMed ID: 21798747
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  • 16. Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.
    Tomei L, Altamura S, Bartholomew L, Bisbocci M, Bailey C, Bosserman M, Cellucci A, Forte E, Incitti I, Orsatti L, Koch U, De Francesco R, Olsen DB, Carroll SS, Migliaccio G.
    J Virol; 2004 Jan 15; 78(2):938-46. PubMed ID: 14694125
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  • 18. Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.
    Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R.
    Gastroenterology; 2014 Nov 15; 147(5):1094-105.e25. PubMed ID: 25046163
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  • 20. Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.
    Chen CM, He Y, Lu L, Lim HB, Tripathi RL, Middleton T, Hernandez LE, Beno DW, Long MA, Kati WM, Bosse TD, Larson DP, Wagner R, Lanford RE, Kohlbrenner WE, Kempf DJ, Pilot-Matias TJ, Molla A.
    Antimicrob Agents Chemother; 2007 Dec 15; 51(12):4290-6. PubMed ID: 17908950
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