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327 related items for PubMed ID: 17114179

  • 1. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
    Ahn KS, Sethi G, Krishnan K, Aggarwal BB.
    J Biol Chem; 2007 Jan 05; 282(1):809-20. PubMed ID: 17114179
    [Abstract] [Full Text] [Related]

  • 2. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.
    Takada Y, Murakami A, Aggarwal BB.
    Oncogene; 2005 Oct 20; 24(46):6957-69. PubMed ID: 16007145
    [Abstract] [Full Text] [Related]

  • 3. Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
    Takada Y, Kobayashi Y, Aggarwal BB.
    J Biol Chem; 2005 Apr 29; 280(17):17203-12. PubMed ID: 15710601
    [Abstract] [Full Text] [Related]

  • 4. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
    Sung B, Pandey MK, Aggarwal BB.
    Mol Pharmacol; 2007 Jun 29; 71(6):1703-14. PubMed ID: 17387141
    [Abstract] [Full Text] [Related]

  • 5. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
    Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB.
    J Biol Chem; 2006 Jun 23; 281(25):17023-17033. PubMed ID: 16624823
    [Abstract] [Full Text] [Related]

  • 6. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis.
    Takada Y, Khuri FR, Aggarwal BB.
    J Biol Chem; 2004 Jun 18; 279(25):26287-99. PubMed ID: 15090542
    [Abstract] [Full Text] [Related]

  • 7. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
    Takada Y, Andreeff M, Aggarwal BB.
    Blood; 2005 Jul 15; 106(2):641-9. PubMed ID: 15811958
    [Abstract] [Full Text] [Related]

  • 8. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.
    Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB.
    Cancer Res; 2005 Oct 15; 65(20):9555-65. PubMed ID: 16230421
    [Abstract] [Full Text] [Related]

  • 9. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
    Takada Y, Gillenwater A, Ichikawa H, Aggarwal BB.
    J Biol Chem; 2006 Mar 03; 281(9):5612-22. PubMed ID: 16377638
    [Abstract] [Full Text] [Related]

  • 10. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
    Shishodia S, Aggarwal BB.
    J Biol Chem; 2004 Nov 05; 279(45):47148-58. PubMed ID: 15322087
    [Abstract] [Full Text] [Related]

  • 11. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
    Ichikawa H, Takada Y, Murakami A, Aggarwal BB.
    J Immunol; 2005 Jun 01; 174(11):7383-92. PubMed ID: 15905586
    [Abstract] [Full Text] [Related]

  • 12. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
    Ahn KS, Sethi G, Aggarwal BB.
    J Immunol; 2007 Feb 15; 178(4):2507-16. PubMed ID: 17277159
    [Abstract] [Full Text] [Related]

  • 13. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
    Takada Y, Singh S, Aggarwal BB.
    J Biol Chem; 2004 Apr 09; 279(15):15096-104. PubMed ID: 14711835
    [Abstract] [Full Text] [Related]

  • 14. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
    Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.
    Clin Cancer Res; 2006 Mar 15; 12(6):1828-38. PubMed ID: 16551868
    [Abstract] [Full Text] [Related]

  • 15. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
    Sethi G, Ahn KS, Pandey MK, Aggarwal BB.
    Blood; 2007 Apr 01; 109(7):2727-35. PubMed ID: 17110449
    [Abstract] [Full Text] [Related]

  • 16. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
    Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB.
    Blood; 2007 Nov 15; 110(10):3517-25. PubMed ID: 17673602
    [Abstract] [Full Text] [Related]

  • 17. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
    Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB.
    Mol Pharmacol; 2006 Jan 15; 69(1):195-206. PubMed ID: 16219905
    [Abstract] [Full Text] [Related]

  • 18. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
    Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB.
    J Biol Chem; 2007 Jun 15; 282(24):17340-50. PubMed ID: 17439942
    [Abstract] [Full Text] [Related]

  • 19. 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
    Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB.
    J Biol Chem; 2012 Jan 02; 287(1):245-256. PubMed ID: 22065587
    [Abstract] [Full Text] [Related]

  • 20. Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
    Park B, Sung B, Yadav VR, Chaturvedi MM, Aggarwal BB.
    Biochem Pharmacol; 2011 Nov 01; 82(9):1134-44. PubMed ID: 21820422
    [Abstract] [Full Text] [Related]

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