These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

229 related items for PubMed ID: 17118664

  • 1. N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin.
    Fortin S, Moreau E, Patenaude A, Desjardins M, Lacroix J, Rousseau JL, C-Gaudreault R.
    Bioorg Med Chem; 2007 Feb 01; 15(3):1430-8. PubMed ID: 17118664
    [Abstract] [Full Text] [Related]

  • 2. N-Phenyl-N'-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents. Part 3: role of carbonyl groups in the covalent binding to the colchicine-binding site.
    Moreau E, Fortin S, Lacroix J, Patenaude A, Rousseau JL, C-Gaudreault R.
    Bioorg Med Chem; 2008 Feb 01; 16(3):1206-17. PubMed ID: 17998163
    [Abstract] [Full Text] [Related]

  • 3. Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site.
    Fortin JS, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2007 Jul 01; 15(13):4456-69. PubMed ID: 17498960
    [Abstract] [Full Text] [Related]

  • 4. Optimized N-phenyl-N'-(2-chloroethyl)ureas as potential antineoplastic agents: synthesis and growth inhibition activity.
    Moreau E, Fortin S, Desjardins M, Rousseau JL, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6703-12. PubMed ID: 16165366
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of action of N-phenyl-N'-(2-chloroethyl)ureas in the colchicine-binding site at the interface between alpha- and beta-tubulin.
    Fortin S, Wei L, Moreau E, Labrie P, Petitclerc E, Kotra LP, C-Gaudreault R.
    Bioorg Med Chem; 2009 May 15; 17(10):3690-7. PubMed ID: 19398206
    [Abstract] [Full Text] [Related]

  • 6.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 7. N-Phenyl-N'-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N'-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
    Fortin S, Moreau E, Lacroix J, Teulade JC, Patenaude A, C-Gaudreault R.
    Bioorg Med Chem Lett; 2007 Apr 01; 17(7):2000-4. PubMed ID: 17291753
    [Abstract] [Full Text] [Related]

  • 8. A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N'-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents.
    Fortin S, Labrie P, Moreau E, Wei L, Kotra LP, C-Gaudreault R.
    Bioorg Med Chem; 2008 Feb 15; 16(4):1914-26. PubMed ID: 18023585
    [Abstract] [Full Text] [Related]

  • 9. Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.
    Trzeciakiewicz A, Fortin S, Moreau E, C-Gaudreault R, Lacroix J, Chambon C, Communal Y, Chezal JM, Miot-Noirault E, Bouchon B, Degoul F.
    Biochem Pharmacol; 2011 May 01; 81(9):1116-23. PubMed ID: 21371445
    [Abstract] [Full Text] [Related]

  • 10. Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents.
    Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7277-90. PubMed ID: 18617414
    [Abstract] [Full Text] [Related]

  • 11. Microtubule disruption induced in vivo by alkylation of beta-tubulin by 1-aryl-3-(2-chloroethyl)ureas, a novel class of soft alkylating agents.
    Legault J, Gaulin JF, Mounetou E, Bolduc S, Lacroix J, Poyet P, Gaudreault RC.
    Cancer Res; 2000 Feb 15; 60(4):985-92. PubMed ID: 10706114
    [Abstract] [Full Text] [Related]

  • 12. Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
    Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R.
    Cancer Res; 2004 Jul 01; 64(13):4654-63. PubMed ID: 15231678
    [Abstract] [Full Text] [Related]

  • 13. Alkylation of beta-tubulin on Glu 198 by a microtubule disrupter.
    Bouchon B, Chambon C, Mounetou E, Papon J, Miot-Noirault E, Gaudreault RC, Madelmont JC, Degoul F.
    Mol Pharmacol; 2005 Nov 01; 68(5):1415-22. PubMed ID: 16099845
    [Abstract] [Full Text] [Related]

  • 14. Synthesis, antiproliferative activity evaluation and structure-activity relationships of novel aromatic urea and amide analogues of N-phenyl-N'-(2-chloroethyl)ureas.
    Fortin S, Moreau E, Lacroix J, Côté MF, Petitclerc E, C-Gaudreault R.
    Eur J Med Chem; 2010 Jul 01; 45(7):2928-37. PubMed ID: 20400211
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and activity evaluation of phenylurea derivatives as potent antitumor agents.
    Song DQ, Du NN, Wang YM, He WY, Jiang EZ, Cheng SX, Wang YX, Li YH, Wang YP, Li X, Jiang JD.
    Bioorg Med Chem; 2009 Jun 01; 17(11):3873-8. PubMed ID: 19410466
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents.
    Li HQ, Yan T, Yang Y, Shi L, Zhou CF, Zhu HL.
    Bioorg Med Chem; 2010 Jan 01; 18(1):305-13. PubMed ID: 19914837
    [Abstract] [Full Text] [Related]

  • 17. A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
    Mounetou E, Legault J, Lacroix J, C -Gaudreault R.
    J Med Chem; 2003 Nov 06; 46(23):5055-63. PubMed ID: 14584955
    [Abstract] [Full Text] [Related]

  • 18. Effect of an aryl chloroethyl urea on tubulin and vimentin syntheses in a human breast cancer cell line.
    Poyet P, Ritchot N, Béchard P, Gaudreáult RC.
    Anticancer Res; 1993 Nov 06; 13(5A):1447-52. PubMed ID: 8239518
    [Abstract] [Full Text] [Related]

  • 19. Alkylation of prohibitin by cyclohexylphenyl-chloroethyl urea on an aspartyl residue is associated with cell cycle G(1) arrest in B16 cells.
    Bouchon B, Papon J, Communal Y, Madelmont JC, Degoul F.
    Br J Pharmacol; 2007 Oct 06; 152(4):449-55. PubMed ID: 17704829
    [Abstract] [Full Text] [Related]

  • 20. New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia.
    Patenaude A, Deschesnes RG, Rousseau JL, Petitclerc E, Lacroix J, Côté MF, C-Gaudreault R.
    Cancer Res; 2007 Mar 01; 67(5):2306-16. PubMed ID: 17332362
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 12.