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359 related items for PubMed ID: 17132764

  • 1. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
    Brown HS, Griffin M, Houston JB.
    Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
    [Abstract] [Full Text] [Related]

  • 2. Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance.
    Foster JA, Houston JB, Hallifax D.
    Xenobiotica; 2011 Feb; 41(2):124-36. PubMed ID: 21058916
    [Abstract] [Full Text] [Related]

  • 3. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
    Griffin SJ, Houston JB.
    Drug Metab Dispos; 2004 May; 32(5):552-8. PubMed ID: 15100178
    [Abstract] [Full Text] [Related]

  • 4. Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
    Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A.
    Drug Metab Dispos; 2010 Sep; 38(9):1449-55. PubMed ID: 20501911
    [Abstract] [Full Text] [Related]

  • 5. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ, McGinnity DF, Austin RP.
    Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
    [Abstract] [Full Text] [Related]

  • 6. Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes.
    Floby E, Johansson J, Hoogstraate J, Hewitt NJ, Hill J, Sohlenius-Sternbeck AK.
    Xenobiotica; 2009 Sep; 39(9):656-62. PubMed ID: 19622023
    [Abstract] [Full Text] [Related]

  • 7. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y, Terashita S, Kimura S, Suzuki A, Kagayama A, Sugiyama Y.
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
    [Abstract] [Full Text] [Related]

  • 8. Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.
    Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A.
    Drug Metab Dispos; 2009 Jan; 37(1):82-9. PubMed ID: 18832476
    [Abstract] [Full Text] [Related]

  • 9. Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Zanelli U, Caradonna NP, Hallifax D, Turlizzi E, Houston JB.
    Drug Metab Dispos; 2012 Jan; 40(1):104-10. PubMed ID: 21998403
    [Abstract] [Full Text] [Related]

  • 10. Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures.
    Griffin SJ, Houston JB.
    Drug Metab Dispos; 2005 Jan; 33(1):115-20. PubMed ID: 15608354
    [Abstract] [Full Text] [Related]

  • 11. Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.
    Lu C, Li P, Gallegos R, Uttamsingh V, Xia CQ, Miwa GT, Balani SK, Gan LS.
    Drug Metab Dispos; 2006 Sep; 34(9):1600-5. PubMed ID: 16790553
    [Abstract] [Full Text] [Related]

  • 12. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
    [Abstract] [Full Text] [Related]

  • 13. Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.
    Carlile DJ, Zomorodi K, Houston JB.
    Drug Metab Dispos; 1997 Aug; 25(8):903-11. PubMed ID: 9280396
    [Abstract] [Full Text] [Related]

  • 14. Rifampin induces the in vitro oxidative metabolism, but not the in vivo clearance of diclofenac in rhesus monkeys.
    Prueksaritanont T, Li C, Tang C, Kuo Y, Strong-Basalyga K, Carr B.
    Drug Metab Dispos; 2006 Nov; 34(11):1806-10. PubMed ID: 16928785
    [Abstract] [Full Text] [Related]

  • 15. Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
    Stringer RA, Strain-Damerell C, Nicklin P, Houston JB.
    Drug Metab Dispos; 2009 May; 37(5):1025-34. PubMed ID: 19196847
    [Abstract] [Full Text] [Related]

  • 16. Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.
    Sohlenius-Sternbeck AK, Afzelius L, Prusis P, Neelissen J, Hoogstraate J, Johansson J, Floby E, Bengtsson A, Gissberg O, Sternbeck J, Petersson C.
    Xenobiotica; 2010 Sep; 40(9):637-49. PubMed ID: 20624033
    [Abstract] [Full Text] [Related]

  • 17. Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.
    Hallifax D, Rawden HC, Hakooz N, Houston JB.
    Drug Metab Dispos; 2005 Dec; 33(12):1852-8. PubMed ID: 16174807
    [Abstract] [Full Text] [Related]

  • 18. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.
    Miners JO, Knights KM, Houston JB, Mackenzie PI.
    Biochem Pharmacol; 2006 May 28; 71(11):1531-9. PubMed ID: 16455060
    [Abstract] [Full Text] [Related]

  • 19. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.
    McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ.
    Drug Metab Dispos; 2004 Nov 28; 32(11):1247-53. PubMed ID: 15286053
    [Abstract] [Full Text] [Related]

  • 20. Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition.
    Worboys PD, Brennan B, Bradbury A, Houston JB.
    Xenobiotica; 1996 Sep 28; 26(9):897-907. PubMed ID: 8893037
    [Abstract] [Full Text] [Related]

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