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Journal Abstract Search

197 related items for PubMed ID: 17148759

  • 1. The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.
    Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB.
    Mol Cancer Ther; 2006 Dec; 5(12):3232-9. PubMed ID: 17148759
    [Abstract] [Full Text] [Related]

  • 2. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
    Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.
    Clin Cancer Res; 2006 Mar 15; 12(6):1828-38. PubMed ID: 16551868
    [Abstract] [Full Text] [Related]

  • 3. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
    Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D.
    J Biol Chem; 2006 Nov 24; 281(47):35764-9. PubMed ID: 16998237
    [Abstract] [Full Text] [Related]

  • 4. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
    Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.
    Cancer Res; 2006 Feb 15; 66(4):2488-94. PubMed ID: 16489057
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  • 5. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
    Place AE, Suh N, Williams CR, Risingsong R, Honda T, Honda Y, Gribble GW, Leesnitzer LM, Stimmel JB, Willson TM, Rosen E, Sporn MB.
    Clin Cancer Res; 2003 Jul 15; 9(7):2798-806. PubMed ID: 12855660
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  • 6. Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): application of systems biology to understand the mechanism of action.
    Wang X, Bynum JA, Stavchansky S, Bowman PD.
    Eur J Pharmacol; 2014 Jul 05; 734():122-31. PubMed ID: 24703885
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  • 8. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.
    Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M.
    J Biol Chem; 2005 Oct 28; 280(43):36273-82. PubMed ID: 16118208
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  • 9. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.
    Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.
    Cancer Res; 2005 Jun 01; 65(11):4789-98. PubMed ID: 15930299
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  • 11. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.
    To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM.
    J Biol Chem; 2008 Apr 25; 283(17):11700-13. PubMed ID: 18283107
    [Abstract] [Full Text] [Related]

  • 12. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
    Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT.
    Pharmacol Res; 2015 Oct 25; 100():135-47. PubMed ID: 26238177
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  • 14. The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells.
    Ji Y, Lee HJ, Goodman C, Uskokovic M, Liby K, Sporn M, Suh N.
    Mol Cancer Ther; 2006 Jun 25; 5(6):1452-8. PubMed ID: 16818503
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  • 19. The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
    Fitzpatrick LR, Stonesifer E, Small JS, Liby KT.
    Inflammopharmacology; 2014 Dec 25; 22(6):341-9. PubMed ID: 24715223
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