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Journal Abstract Search

333 related items for PubMed ID: 17149858

  • 1. Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists.
    Le Bourdonnec B, Goodman AJ, Michaut M, Ye HF, Graczyk TM, Belanger S, Herbertz T, Yap GP, DeHaven RN, Dolle RE.
    J Med Chem; 2006 Dec 14; 49(25):7278-89. PubMed ID: 17149858
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and pharmacological evaluation of novel octahydro-1H-pyrido[1,2-a]pyrazine as mu-opioid receptor antagonists.
    Le Bourdonnec B, Goodman AJ, Graczyk TM, Belanger S, Seida PR, DeHaven RN, Dolle RE.
    J Med Chem; 2006 Dec 14; 49(25):7290-306. PubMed ID: 17149859
    [Abstract] [Full Text] [Related]

  • 3. Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.
    Thomas JB, Mascarella SW, Rothman RB, Partilla JS, Xu H, McCullough KB, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI.
    J Med Chem; 1998 May 21; 41(11):1980-90. PubMed ID: 9599247
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  • 4. N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
    Thomas JB, Zheng X, Mascarella SW, Rothman RB, Dersch CM, Partilla JS, Flippen-Anderson JL, George CF, Cantrell BE, Zimmerman DM, Carroll FI.
    J Med Chem; 1998 Oct 08; 41(21):4143-9. PubMed ID: 9767649
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists.
    Le Bourdonnec B, Goodman AJ, Michaut M, Ye HF, Graczyk TM, Belanger S, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):864-8. PubMed ID: 16298525
    [Abstract] [Full Text] [Related]

  • 6. Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
    Thomas JB, Fall MJ, Cooper JB, Rothman RB, Mascarella SW, Xu H, Partilla JS, Dersch CM, McCullough KB, Cantrell BE, Zimmerman DM, Carroll FI.
    J Med Chem; 1998 Dec 17; 41(26):5188-97. PubMed ID: 9857089
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  • 8. Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
    Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI.
    J Med Chem; 2003 Jul 03; 46(14):3127-37. PubMed ID: 12825951
    [Abstract] [Full Text] [Related]

  • 9. Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.
    Ioja E, Tourwé D, Kertész I, Tóth G, Borsodi A, Benyhe S.
    Brain Res Bull; 2007 Sep 14; 74(1-3):119-29. PubMed ID: 17683797
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
    Cai TB, Zou Z, Thomas JB, Brieaddy L, Navarro HA, Carroll FI.
    J Med Chem; 2008 Mar 27; 51(6):1849-60. PubMed ID: 18307295
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  • 12. Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists.
    Emmerson PJ, McKinzie JH, Surface PL, Suter TM, Mitch CH, Statnick MA.
    Eur J Pharmacol; 2004 Jun 28; 494(2-3):121-30. PubMed ID: 15212965
    [Abstract] [Full Text] [Related]

  • 13. N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
    Carroll FI, Chaudhari S, Thomas JB, Mascarella SW, Gigstad KM, Deschamps J, Navarro HA.
    J Med Chem; 2005 Dec 29; 48(26):8182-93. PubMed ID: 16366600
    [Abstract] [Full Text] [Related]

  • 14. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
    Neilan CL, Husbands SM, Breeden S, Ko MC, Aceto MD, Lewis JW, Woods JH, Traynor JR.
    Eur J Pharmacol; 2004 Sep 19; 499(1-2):107-16. PubMed ID: 15363957
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  • 17. Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1.
    Takeuchi K, Holloway WG, McKinzie JH, Suter TM, Statnick MA, Surface PL, Emmerson PJ, Thomas EM, Siegel MG, Matt JE, Wolfe CN, Mitch CH.
    Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5349-52. PubMed ID: 17720493
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  • 19. Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine.
    Wentland MP, VanAlstine M, Kucejko R, Lou R, Cohen DJ, Parkhill AL, Bidlack JM.
    J Med Chem; 2006 Sep 07; 49(18):5635-9. PubMed ID: 16942039
    [Abstract] [Full Text] [Related]

  • 20. Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.
    Grundt P, Williams IA, Lewis JW, Husbands SM.
    J Med Chem; 2004 Oct 07; 47(21):5069-75. PubMed ID: 15456250
    [Abstract] [Full Text] [Related]

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