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636 related items for PubMed ID: 17157164

  • 1. The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.
    Georgakis GV, Li Y, Rassidakis GZ, Medeiros LJ, Younes A.
    Exp Hematol; 2006 Dec; 34(12):1670-9. PubMed ID: 17157164
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV, Li Y, Rassidakis GZ, Martinez-Valdez H, Medeiros LJ, Younes A.
    Clin Cancer Res; 2006 Jan 15; 12(2):584-90. PubMed ID: 16428504
    [Abstract] [Full Text] [Related]

  • 3. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.
    Bonvini P, Gastaldi T, Falini B, Rosolen A.
    Cancer Res; 2002 Mar 01; 62(5):1559-66. PubMed ID: 11888936
    [Abstract] [Full Text] [Related]

  • 4. 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.
    Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F.
    Invest Ophthalmol Vis Sci; 2008 Jun 01; 49(6):2348-56. PubMed ID: 18281615
    [Abstract] [Full Text] [Related]

  • 5. Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
    Schumacher JA, Crockett DK, Elenitoba-Johnson KS, Lim MS.
    Proteomics; 2007 Aug 01; 7(15):2603-16. PubMed ID: 17610208
    [Abstract] [Full Text] [Related]

  • 6. Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein.
    Bonvini P, Dalla Rosa H, Vignes N, Rosolen A.
    Cancer Res; 2004 May 01; 64(9):3256-64. PubMed ID: 15126367
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
    Srethapakdi M, Liu F, Tavorath R, Rosen N.
    Cancer Res; 2000 Jul 15; 60(14):3940-6. PubMed ID: 10919672
    [Abstract] [Full Text] [Related]

  • 8. Synergistic growth inhibition of anaplastic large cell lymphoma cells by combining cellular ALK gene silencing and a low dose of the kinase inhibitor U0126.
    Ito M, Zhao N, Zeng Z, Chang CC, Zu Y.
    Cancer Gene Ther; 2010 Sep 15; 17(9):633-44. PubMed ID: 20448669
    [Abstract] [Full Text] [Related]

  • 9. The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.
    Pearson JD, Mohammed Z, Bacani JT, Lai R, Ingham RJ.
    BMC Cancer; 2012 Jun 08; 12():229. PubMed ID: 22681779
    [Abstract] [Full Text] [Related]

  • 10. The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.
    Yu W, Rao Q, Wang M, Tian Z, Lin D, Liu X, Wang J.
    Leuk Res; 2006 May 08; 30(5):575-82. PubMed ID: 16213582
    [Abstract] [Full Text] [Related]

  • 11. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
    Vega F, Medeiros LJ, Leventaki V, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ.
    Cancer Res; 2006 Jul 01; 66(13):6589-97. PubMed ID: 16818631
    [Abstract] [Full Text] [Related]

  • 12. Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.
    George P, Bali P, Cohen P, Tao J, Guo F, Sigua C, Vishvanath A, Fiskus W, Scuto A, Annavarapu S, Moscinski L, Bhalla K.
    Cancer Res; 2004 May 15; 64(10):3645-52. PubMed ID: 15150124
    [Abstract] [Full Text] [Related]

  • 13. MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells.
    Zhang T, Li Y, Zhu Z, Gu M, Newman B, Sun D.
    Mol Pharm; 2010 Oct 04; 7(5):1576-84. PubMed ID: 20669973
    [Abstract] [Full Text] [Related]

  • 14. Silibinin suppresses NPM-ALK, potently induces apoptosis and enhances chemosensitivity in ALK-positive anaplastic large cell lymphoma.
    Molavi O, Samadi N, Wu C, Lavasanifar A, Lai R.
    Leuk Lymphoma; 2016 May 04; 57(5):1154-62. PubMed ID: 26133723
    [Abstract] [Full Text] [Related]

  • 15. Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells.
    Wu WC, Wu MH, Chang YC, Hsieh MC, Wu HJ, Cheng KC, Lai YH, Kao YH.
    Exp Eye Res; 2010 Aug 04; 91(2):211-9. PubMed ID: 20493187
    [Abstract] [Full Text] [Related]

  • 16. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.
    J Pathol; 2007 Oct 04; 213(2):170-9. PubMed ID: 17768706
    [Abstract] [Full Text] [Related]

  • 17. The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
    Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y.
    Oncol Rep; 2014 Feb 04; 31(2):619-24. PubMed ID: 24317439
    [Abstract] [Full Text] [Related]

  • 18. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
    Robles AI, Wright MH, Gandhi B, Feis SS, Hanigan CL, Wiestner A, Varticovski L.
    Clin Cancer Res; 2006 Nov 01; 12(21):6547-56. PubMed ID: 17085670
    [Abstract] [Full Text] [Related]

  • 19. The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
    Georgakis GV, Li Y, Younes A.
    Br J Haematol; 2006 Oct 01; 135(1):68-71. PubMed ID: 16925576
    [Abstract] [Full Text] [Related]

  • 20. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.
    Yao Q, Nishiuchi R, Li Q, Kumar AR, Hudson WA, Kersey JH.
    Clin Cancer Res; 2003 Oct 01; 9(12):4483-93. PubMed ID: 14555522
    [Abstract] [Full Text] [Related]

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