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372 related items for PubMed ID: 17181155

  • 1. Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.
    Doshi JM, Tian D, Xing C.
    J Med Chem; 2006 Dec 28; 49(26):7731-9. PubMed ID: 17181155
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  • 2. Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.
    Doshi JM, Tian D, Xing C.
    Mol Pharm; 2007 Dec 28; 4(6):919-28. PubMed ID: 17874842
    [Abstract] [Full Text] [Related]

  • 3. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.
    Manero F, Gautier F, Gallenne T, Cauquil N, Grée D, Cartron PF, Geneste O, Grée R, Vallette FM, Juin P.
    Cancer Res; 2006 Mar 01; 66(5):2757-64. PubMed ID: 16510597
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  • 7. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.
    Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H.
    Carcinogenesis; 2009 Sep 01; 30(9):1517-27. PubMed ID: 19578044
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  • 10. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
    Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW.
    J Med Chem; 2007 Feb 22; 50(4):641-62. PubMed ID: 17256834
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  • 11. Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells.
    Jin CY, Park C, Lee JH, Chung KT, Kwon TK, Kim GY, Choi BT, Choi YH.
    Toxicol In Vitro; 2009 Mar 22; 23(2):259-65. PubMed ID: 19124070
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  • 12. Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.
    Shallal HM, Faridi JS, Russu WA.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1325-8. PubMed ID: 21300543
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  • 13. Molecular targeting of BCL2 and BCLXL proteins by synthetic BCL2 homology 3 domain peptide enhances the efficacy of chemotherapy.
    Dharap SS, Chandna P, Wang Y, Khandare JJ, Qiu B, Stein S, Minko T.
    J Pharmacol Exp Ther; 2006 Mar 01; 316(3):992-8. PubMed ID: 16291730
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  • 14. sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.
    Tian D, Das SG, Doshi JM, Peng J, Lin J, Xing C.
    Cancer Lett; 2008 Feb 08; 259(2):198-208. PubMed ID: 18037229
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  • 15. Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines.
    Ali MA, Rosati R, Pettit GR, Kalemkerian GP.
    Anticancer Res; 1998 Feb 08; 18(2A):1021-6. PubMed ID: 9615758
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  • 16. Antitumor activity of a novel bis-aziridinylnaphthoquinone (AZ4) mediating cell cycle arrest and apoptosis in non-small cell lung cancer cell line NCI-H460.
    Shyu KG, Huang ST, Kuo HS, Cheng WP, Lin YL.
    Acta Pharmacol Sin; 2007 Apr 08; 28(4):559-66. PubMed ID: 17376296
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  • 17. Effect of HA14-1 on apoptosis-regulating proteins in HeLa cells.
    Rehman K, Tariq M, Akash MS, Gillani Z, Qazi MH.
    Chem Biol Drug Des; 2014 Mar 08; 83(3):317-23. PubMed ID: 24118733
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  • 19. Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.
    Chu F, Barkinge J, Hawkins S, Gudi R, Salgia R, Kanteti PV.
    Cancer Res; 2005 Jun 15; 65(12):5301-9. PubMed ID: 15958577
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  • 20. Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.
    Tang G, Nikolovska-Coleska Z, Qiu S, Yang CY, Guo J, Wang S.
    J Med Chem; 2008 Feb 28; 51(4):717-20. PubMed ID: 18237106
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