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145 related items for PubMed ID: 17185412

  • 1. Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.
    Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
    Proc Natl Acad Sci U S A; 2007 Jan 02; 104(1):359-64. PubMed ID: 17185412
    [Abstract] [Full Text] [Related]

  • 2. Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.
    Rummel A, Karnath T, Henke T, Bigalke H, Binz T.
    J Biol Chem; 2004 Jul 16; 279(29):30865-70. PubMed ID: 15123599
    [Abstract] [Full Text] [Related]

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  • 4. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
    Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.
    Biochemistry; 2013 Jun 04; 52(22):3930-8. PubMed ID: 23647335
    [Abstract] [Full Text] [Related]

  • 5. Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.
    Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M.
    J Cell Sci; 2012 Jul 01; 125(Pt 13):3233-42. PubMed ID: 22454523
    [Abstract] [Full Text] [Related]

  • 6. Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
    Chai Q, Arndt JW, Dong M, Tepp WH, Johnson EA, Chapman ER, Stevens RC.
    Nature; 2006 Dec 21; 444(7122):1096-100. PubMed ID: 17167418
    [Abstract] [Full Text] [Related]

  • 7. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
    Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
    Biochem J; 2010 Oct 15; 431(2):207-16. PubMed ID: 20704566
    [Abstract] [Full Text] [Related]

  • 8. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
    Jin R, Rummel A, Binz T, Brunger AT.
    Nature; 2006 Dec 21; 444(7122):1092-5. PubMed ID: 17167421
    [Abstract] [Full Text] [Related]

  • 9. Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons.
    Dong M, Tepp WH, Liu H, Johnson EA, Chapman ER.
    J Cell Biol; 2007 Dec 31; 179(7):1511-22. PubMed ID: 18158333
    [Abstract] [Full Text] [Related]

  • 10. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
    Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T.
    J Neurochem; 2009 Sep 31; 110(6):1942-54. PubMed ID: 19650874
    [Abstract] [Full Text] [Related]

  • 11. The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    Mol Microbiol; 2004 Feb 31; 51(3):631-43. PubMed ID: 14731268
    [Abstract] [Full Text] [Related]

  • 12. Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
    Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT.
    J Biol Chem; 2012 Nov 23; 287(48):40806-16. PubMed ID: 23027864
    [Abstract] [Full Text] [Related]

  • 13. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
    Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.
    Toxicon; 2013 Dec 01; 75():108-21. PubMed ID: 23817019
    [Abstract] [Full Text] [Related]

  • 14. Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex.
    Kohda T, Ihara H, Seto Y, Tsutsuki H, Mukamoto M, Kozaki S.
    Microb Pathog; 2007 Dec 01; 42(2-3):72-9. PubMed ID: 17188834
    [Abstract] [Full Text] [Related]

  • 15. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    FEBS J; 2011 Dec 01; 278(23):4506-15. PubMed ID: 21624052
    [Abstract] [Full Text] [Related]

  • 16. Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding.
    Stenmark P, Dong M, Dupuy J, Chapman ER, Stevens RC.
    J Mol Biol; 2010 Apr 16; 397(5):1287-97. PubMed ID: 20219474
    [Abstract] [Full Text] [Related]

  • 17. Synaptotagmin II and gangliosides bind independently with botulinum neurotoxin B but each restrains the other.
    Atassi MZ, Taruishi M, Naqvi M, Steward LE, Aoki KR.
    Protein J; 2014 Jun 16; 33(3):278-88. PubMed ID: 24740609
    [Abstract] [Full Text] [Related]

  • 18. Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
    Baldwin MR, Barbieri JT.
    Biochemistry; 2007 Mar 20; 46(11):3200-10. PubMed ID: 17311420
    [Abstract] [Full Text] [Related]

  • 19. Structure of dual receptor binding to botulinum neurotoxin B.
    Berntsson RP, Peng L, Dong M, Stenmark P.
    Nat Commun; 2013 Mar 20; 4():2058. PubMed ID: 23807078
    [Abstract] [Full Text] [Related]

  • 20. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.
    Rummel A.
    Curr Top Microbiol Immunol; 2013 Mar 20; 364():61-90. PubMed ID: 23239349
    [Abstract] [Full Text] [Related]

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