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Journal Abstract Search

1315 related items for PubMed ID: 17191947

  • 1. Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.
    Lüpfert C, Reichel A.
    Chem Biodivers; 2005 Nov; 2(11):1462-86. PubMed ID: 17191947
    [Abstract] [Full Text] [Related]

  • 2. Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.
    De Buck SS, Mackie CE.
    Expert Opin Drug Metab Toxicol; 2007 Dec; 3(6):865-78. PubMed ID: 18028030
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability.
    Cai H, Stoner C, Reddy A, Freiwald S, Smith D, Winters R, Stankovic C, Surendran N.
    Int J Pharm; 2006 Feb 03; 308(1-2):133-9. PubMed ID: 16352407
    [Abstract] [Full Text] [Related]

  • 4. Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.
    Chen Y, Jin JY, Mukadam S, Malhi V, Kenny JR.
    Biopharm Drug Dispos; 2012 Mar 03; 33(2):85-98. PubMed ID: 22228214
    [Abstract] [Full Text] [Related]

  • 5. Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.
    Poulin P, Theil FP.
    J Pharm Sci; 2002 May 03; 91(5):1358-70. PubMed ID: 11977112
    [Abstract] [Full Text] [Related]

  • 6. Physiologically based pharmacokinetics (PBPK).
    Espié P, Tytgat D, Sargentini-Maier ML, Poggesi I, Watelet JB.
    Drug Metab Rev; 2009 May 03; 41(3):391-407. PubMed ID: 19601719
    [Abstract] [Full Text] [Related]

  • 7. PBPK models in risk assessment--A focus on chloroprene.
    DeWoskin RS.
    Chem Biol Interact; 2007 Mar 20; 166(1-3):352-9. PubMed ID: 17324392
    [Abstract] [Full Text] [Related]

  • 8. Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in rat plasma.
    Brightman FA, Leahy DE, Searle GE, Thomas S.
    Drug Metab Dispos; 2006 Jan 20; 34(1):84-93. PubMed ID: 16221757
    [Abstract] [Full Text] [Related]

  • 9. Applications of high-throughput ADME in drug discovery.
    Kassel DB.
    Curr Opin Chem Biol; 2004 Jun 20; 8(3):339-45. PubMed ID: 15183334
    [Abstract] [Full Text] [Related]

  • 10. PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
    Poulin P, Jones RD, Jones HM, Gibson CR, Rowland M, Chien JY, Ring BJ, Adkison KK, Ku MS, He H, Vuppugalla R, Marathe P, Fischer V, Dutta S, Sinha VK, Björnsson T, Lavé T, Yates JW.
    J Pharm Sci; 2011 Oct 20; 100(10):4127-57. PubMed ID: 21541937
    [Abstract] [Full Text] [Related]

  • 11. Physiologically based pharmacokinetic (PBPK) modeling and simulation: applications in lead optimization.
    Peters SA, Ungell AL, Dolgos H.
    Curr Opin Drug Discov Devel; 2009 Jul 20; 12(4):509-18. PubMed ID: 19562647
    [Abstract] [Full Text] [Related]

  • 12. Use of intrinsic clearance for prediction of human hepatic clearance.
    Chao P, Uss AS, Cheng KC.
    Expert Opin Drug Metab Toxicol; 2010 Feb 20; 6(2):189-98. PubMed ID: 20073997
    [Abstract] [Full Text] [Related]

  • 13. Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.
    Poirier A, Funk C, Scherrmann JM, Lavé T.
    Mol Pharm; 2009 Feb 20; 6(6):1716-33. PubMed ID: 19739673
    [Abstract] [Full Text] [Related]

  • 14. Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods.
    Tsaioun K, Blaauboer BJ, Hartung T.
    ALTEX; 2016 Feb 20; 33(4):343-358. PubMed ID: 27806179
    [Abstract] [Full Text] [Related]

  • 15. Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.
    De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA.
    Drug Metab Dispos; 2007 Oct 20; 35(10):1766-80. PubMed ID: 17620347
    [Abstract] [Full Text] [Related]

  • 16. Integration of dissolution into physiologically-based pharmacokinetic models III: PK-Sim®.
    Willmann S, Thelen K, Lippert J.
    J Pharm Pharmacol; 2012 Jul 20; 64(7):997-1007. PubMed ID: 22686345
    [Abstract] [Full Text] [Related]

  • 17. Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
    Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS.
    Drug Metab Dispos; 2012 May 20; 40(5):1007-17. PubMed ID: 22344703
    [Abstract] [Full Text] [Related]

  • 18. PBPK models for the prediction of in vivo performance of oral dosage forms.
    Kostewicz ES, Aarons L, Bergstrand M, Bolger MB, Galetin A, Hatley O, Jamei M, Lloyd R, Pepin X, Rostami-Hodjegan A, Sjögren E, Tannergren C, Turner DB, Wagner C, Weitschies W, Dressman J.
    Eur J Pharm Sci; 2014 Jun 16; 57():300-21. PubMed ID: 24060672
    [Abstract] [Full Text] [Related]

  • 19. Predicting human pharmacokinetics from preclinical data.
    Poggesi I.
    Curr Opin Drug Discov Devel; 2004 Jan 16; 7(1):100-11. PubMed ID: 14982153
    [Abstract] [Full Text] [Related]

  • 20. Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.
    Germani M, Crivori P, Rocchetti M, Burton PS, Wilson AG, Smith ME, Poggesi I.
    Eur J Pharm Sci; 2007 Jul 16; 31(3-4):190-201. PubMed ID: 17481865
    [Abstract] [Full Text] [Related]

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