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327 related items for PubMed ID: 1719558

  • 1. Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
    Nakayama T, Samelson LE, Nakayama Y, Munitz TI, Sheard M, June CH, Singer A.
    Proc Natl Acad Sci U S A; 1991 Nov 15; 88(22):9949-53. PubMed ID: 1719558
    [Abstract] [Full Text] [Related]

  • 2. Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
    Kearse KP, Wiest DL, Singer A.
    Proc Natl Acad Sci U S A; 1993 Mar 15; 90(6):2438-42. PubMed ID: 7681596
    [Abstract] [Full Text] [Related]

  • 3. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
    Wiest DL, Yuan L, Jefferson J, Benveniste P, Tsokos M, Klausner RD, Glimcher LH, Samelson LE, Singer A.
    J Exp Med; 1993 Nov 01; 178(5):1701-12. PubMed ID: 8228817
    [Abstract] [Full Text] [Related]

  • 4. TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck.
    Wiest DL, Ashe JM, Abe R, Bolen JB, Singer A.
    Immunity; 1996 May 01; 4(5):495-504. PubMed ID: 8630734
    [Abstract] [Full Text] [Related]

  • 5. Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.
    Kearse KP, Takahama Y, Punt JA, Sharrow SO, Singer A.
    J Exp Med; 1995 Jan 01; 181(1):193-202. PubMed ID: 7528767
    [Abstract] [Full Text] [Related]

  • 6. Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain.
    Nakayama T, Singer A, Hsi ED, Samelson LE.
    Nature; 1989 Oct 19; 341(6243):651-4. PubMed ID: 2477711
    [Abstract] [Full Text] [Related]

  • 7. Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
    Nakayama T, Wiest DL, Abraham KM, Munitz TI, Perlmutter RM, Singer A.
    Proc Natl Acad Sci U S A; 1993 Nov 15; 90(22):10534-8. PubMed ID: 7902564
    [Abstract] [Full Text] [Related]

  • 8. Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells.
    Takahama Y, Shores EW, Singer A.
    Science; 1992 Oct 23; 258(5082):653-6. PubMed ID: 1357752
    [Abstract] [Full Text] [Related]

  • 9. The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.
    Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS.
    J Exp Med; 1994 Jan 01; 179(1):145-53. PubMed ID: 8270861
    [Abstract] [Full Text] [Related]

  • 10. Thymic selection generates T cells expressing self-reactive TCRs in the absence of CD45.
    Trop S, Charron J, Arguin C, Lesage S, Hugo P.
    J Immunol; 2000 Sep 15; 165(6):3073-9. PubMed ID: 10975818
    [Abstract] [Full Text] [Related]

  • 11. In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands.
    Nakayama T, Ueda Y, Yamada H, Shores EW, Singer A, June CH.
    Science; 1992 Jul 03; 257(5066):96-9. PubMed ID: 1621102
    [Abstract] [Full Text] [Related]

  • 12. The final maturation of at least some single-positive CD4(hi) thymocytes does not require T cell receptor-major histocompatibility complex contact.
    Dyall R, Nikolic-Zugić J.
    J Exp Med; 1999 Sep 20; 190(6):757-64. PubMed ID: 10499914
    [Abstract] [Full Text] [Related]

  • 13. Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.
    Keir ME, Latchman YE, Freeman GJ, Sharpe AH.
    J Immunol; 2005 Dec 01; 175(11):7372-9. PubMed ID: 16301644
    [Abstract] [Full Text] [Related]

  • 14. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene.
    Strasser A, Harris AW, von Boehmer H, Cory S.
    Proc Natl Acad Sci U S A; 1994 Feb 15; 91(4):1376-80. PubMed ID: 8108419
    [Abstract] [Full Text] [Related]

  • 15. Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages.
    Crompton T, Lees RK, Pircher H, MacDonald HR.
    Proc Natl Acad Sci U S A; 1993 Oct 01; 90(19):8982-6. PubMed ID: 8415641
    [Abstract] [Full Text] [Related]

  • 16. Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction.
    Martinez M, Samms M, Hendrix TM, Adeosun O, Pezzano M, Guyden JC.
    Exp Biol Med (Maywood); 2007 Jun 01; 232(6):780-8. PubMed ID: 17526770
    [Abstract] [Full Text] [Related]

  • 17. CD8 inhibits signal transduction through the T cell receptor in CD4-CD8- thymocytes from T cell receptor transgenic mice reconstituted with a transgenic CD8 alpha molecule.
    van Oers NS, Teh SJ, Garvin AM, Forbush KA, Perlmutter RM, Teh HS.
    J Immunol; 1993 Jul 15; 151(2):777-90. PubMed ID: 8335907
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4.
    Nakayama T, June CH, Munitz TI, Sheard M, McCarthy SA, Sharrow SO, Samelson LE, Singer A.
    Science; 1990 Sep 28; 249(4976):1558-61. PubMed ID: 2120773
    [Abstract] [Full Text] [Related]

  • 19. TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.
    Groves T, Parsons M, Miyamoto NG, Guidos CJ.
    J Immunol; 1997 Jan 01; 158(1):65-75. PubMed ID: 8977176
    [Abstract] [Full Text] [Related]

  • 20. Spontaneous clustering of Thy-1 antigens on CD4+ CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes.
    Sano T, Yamamoto K, Fukui Y, Sasazuki T.
    Eur J Immunol; 1999 Feb 01; 29(2):403-12. PubMed ID: 10064055
    [Abstract] [Full Text] [Related]

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