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Journal Abstract Search

236 related items for PubMed ID: 17207630

  • 1. Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.
    Vingtdeux V, Hamdane M, Bégard S, Loyens A, Delacourte A, Beauvillain JC, Buée L, Marambaud P, Sergeant N.
    Neurobiol Dis; 2007 Mar; 25(3):686-96. PubMed ID: 17207630
    [Abstract] [Full Text] [Related]

  • 2. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H, Maruyama K, Kametani F.
    Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
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  • 3. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH, Sohn JH, Kim JE, Song H, Mook-Jung I.
    Biochem Biophys Res Commun; 2008 Aug 08; 372(4):913-7. PubMed ID: 18538664
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  • 4. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
    Kaether C, Schmitt S, Willem M, Haass C.
    Traffic; 2006 Apr 08; 7(4):408-15. PubMed ID: 16536739
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  • 5. Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.
    Flammang B, Pardossi-Piquard R, Sevalle J, Debayle D, Dabert-Gay AS, Thévenet A, Lauritzen I, Checler F.
    J Alzheimers Dis; 2012 Apr 08; 30(1):145-53. PubMed ID: 22406447
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  • 6. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
    Lefranc-Jullien S, Sunyach C, Checler F.
    J Neurochem; 2006 May 08; 97(3):807-17. PubMed ID: 16524370
    [Abstract] [Full Text] [Related]

  • 7. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.
    Araki W, Kume H, Oda A, Tamaoka A, Kametani F.
    Biochem Biophys Res Commun; 2009 Feb 27; 380(1):111-4. PubMed ID: 19167357
    [Abstract] [Full Text] [Related]

  • 8. Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.
    Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS.
    Biochemistry; 2003 Jun 24; 42(24):7580-6. PubMed ID: 12809514
    [Abstract] [Full Text] [Related]

  • 9. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 24; 331(2):598-608. PubMed ID: 19671883
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  • 12. Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.
    Schrader-Fischer G, Paganetti PA.
    Brain Res; 1996 Apr 15; 716(1-2):91-100. PubMed ID: 8738224
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  • 13. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.
    Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U.
    J Cell Sci; 2009 Oct 15; 122(Pt 20):3703-14. PubMed ID: 19773363
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  • 15. The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
    Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN.
    J Neurochem; 2007 May 15; 101(3):854-62. PubMed ID: 17448150
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  • 17. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 15; 110(1):275-83. PubMed ID: 19457123
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  • 19. An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.
    Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K.
    FASEB J; 2011 Oct 15; 25(10):3720-30. PubMed ID: 21746863
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