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808 related items for PubMed ID: 17226936

  • 1. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 2. Thioether adducts of a new imine reactive intermediate of the pneumotoxin 3-methylindole.
    Skordos KW, Laycock JD, Yost GS.
    Chem Res Toxicol; 1998 Nov; 11(11):1326-31. PubMed ID: 9815193
    [Abstract] [Full Text] [Related]

  • 3. Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes.
    Diaz GJ, Skordos KW, Yost GS, Squires EJ.
    Drug Metab Dispos; 1999 Oct; 27(10):1150-6. PubMed ID: 10497141
    [Abstract] [Full Text] [Related]

  • 4. Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.
    Skordos KW, Skiles GL, Laycock JD, Lanza DL, Yost GS.
    Chem Res Toxicol; 1998 Jul; 11(7):741-9. PubMed ID: 9671536
    [Abstract] [Full Text] [Related]

  • 5. Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages, and subcellular fractions from rabbit lungs.
    Thornton-Manning JR, Nichols WK, Manning BW, Skiles GL, Yost GS.
    Toxicol Appl Pharmacol; 1993 Oct; 122(2):182-90. PubMed ID: 8212000
    [Abstract] [Full Text] [Related]

  • 6. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
    Yan Z, Zhong HM, Maher N, Torres R, Leo GC, Caldwell GW, Huebert N.
    Drug Metab Dispos; 2005 Dec; 33(12):1867-76. PubMed ID: 16174805
    [Abstract] [Full Text] [Related]

  • 7. Structure of the glutathione adduct of activated 3-methylindole indicates that an imine methide is the electrophilic intermediate.
    Nocerini MR, Yost GS, Carlson JR, Liberato DJ, Breeze RG.
    Drug Metab Dispos; 1985 Dec; 13(6):690-4. PubMed ID: 2867872
    [Abstract] [Full Text] [Related]

  • 8. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 9. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [Abstract] [Full Text] [Related]

  • 10. 17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation.
    Butterworth M, Lau SS, Monks TJ.
    Chem Res Toxicol; 1996 Jun; 9(4):793-9. PubMed ID: 8831825
    [Abstract] [Full Text] [Related]

  • 11. Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry.
    Bu HZ, Zhao P, Dalvie DK, Pool WF.
    Rapid Commun Mass Spectrom; 2007 Jun; 21(20):3317-22. PubMed ID: 17879390
    [Abstract] [Full Text] [Related]

  • 12. Glutathione adduct formation with microsomally activated metabolites of the pulmonary alkylating and cytotoxic agent, 3-methylindole.
    Nocerini MR, Carlson JR, Yost GS.
    Toxicol Appl Pharmacol; 1985 Oct; 81(1):75-84. PubMed ID: 4049423
    [Abstract] [Full Text] [Related]

  • 13. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

  • 14. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
    Wen B, Ma L, Rodrigues AD, Zhu M.
    Drug Metab Dispos; 2008 May; 36(5):841-50. PubMed ID: 18238857
    [Abstract] [Full Text] [Related]

  • 15. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
    Tang C, Subramanian R, Kuo Y, Krymgold S, Lu P, Kuduk SD, Ng C, Feng DM, Elmore C, Soli E, Ho J, Bock MG, Baillie TA, Prueksaritanont T.
    Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
    [Abstract] [Full Text] [Related]

  • 16. Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
    Yu J, Folmer JJ, Hoesch V, Doherty J, Campbell JB, Burdette D.
    Drug Metab Dispos; 2011 Feb; 39(2):302-11. PubMed ID: 21045198
    [Abstract] [Full Text] [Related]

  • 17. In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
    Yu J, Brown DG, Burdette D.
    Drug Metab Dispos; 2010 Oct; 38(10):1767-78. PubMed ID: 20595377
    [Abstract] [Full Text] [Related]

  • 18. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
    [Abstract] [Full Text] [Related]

  • 19. Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.
    Yan Z, Li J, Huebert N, Caldwell GW, Du Y, Zhong H.
    Drug Metab Dispos; 2005 Jun; 33(6):706-13. PubMed ID: 15764717
    [Abstract] [Full Text] [Related]

  • 20. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M.
    Chem Biol Interact; 2009 Oct 07; 181(2):227-35. PubMed ID: 19576871
    [Abstract] [Full Text] [Related]

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