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Journal Abstract Search


426 related items for PubMed ID: 17275736

  • 1. Fragments, network biology and designing multiple ligands.
    Morphy R, Rankovic Z.
    Drug Discov Today; 2007 Feb; 12(3-4):156-60. PubMed ID: 17275736
    [Abstract] [Full Text] [Related]

  • 2. [Design of multiple targeted drugs].
    Guo YS, Guo ZR.
    Yao Xue Xue Bao; 2009 Mar; 44(3):276-81. PubMed ID: 19449524
    [Abstract] [Full Text] [Related]

  • 3. Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective.
    Zhao H.
    Drug Discov Today; 2007 Feb; 12(3-4):149-55. PubMed ID: 17275735
    [Abstract] [Full Text] [Related]

  • 4. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
    Meanwell NA.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1420-56. PubMed ID: 21790149
    [Abstract] [Full Text] [Related]

  • 5. Network pharmacology: the next paradigm in drug discovery.
    Hopkins AL.
    Nat Chem Biol; 2008 Nov 19; 4(11):682-90. PubMed ID: 18936753
    [Abstract] [Full Text] [Related]

  • 6. Conciliating binding efficiency and polypharmacology.
    Mestres J, Gregori-Puigjané E.
    Trends Pharmacol Sci; 2009 Sep 19; 30(9):470-4. PubMed ID: 19717193
    [Abstract] [Full Text] [Related]

  • 7.
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  • 8. Designing multiple ligands - medicinal chemistry strategies and challenges.
    Morphy R, Rankovic Z.
    Curr Pharm Des; 2009 Sep 19; 15(6):587-600. PubMed ID: 19199984
    [Abstract] [Full Text] [Related]

  • 9. From magic bullets to designed multiple ligands.
    Morphy R, Kay C, Rankovic Z.
    Drug Discov Today; 2004 Aug 01; 9(15):641-51. PubMed ID: 15279847
    [Abstract] [Full Text] [Related]

  • 10. Molecular conceptor for training in medicinal chemistry, drug design, and cheminformatics.
    Cohen C, Fischel O, Cohen E.
    Chem Biol Drug Des; 2007 Jan 01; 69(1):75-82. PubMed ID: 17313460
    [Abstract] [Full Text] [Related]

  • 11. In silico fragment screening by replica generation (FSRG) method for fragment-based drug design.
    Fukunishi Y, Mashimo T, Orita M, Ohno K, Nakamura H.
    J Chem Inf Model; 2009 Apr 01; 49(4):925-33. PubMed ID: 19354203
    [Abstract] [Full Text] [Related]

  • 12. Importance of molecular computer modeling in anticancer drug development.
    Geromichalos GD.
    J BUON; 2007 Sep 01; 12 Suppl 1():S101-18. PubMed ID: 17935268
    [Abstract] [Full Text] [Related]

  • 13. Making drugs on proteins: site-directed ligand discovery for fragment-based lead assembly.
    Erlanson DA, Hansen SK.
    Curr Opin Chem Biol; 2004 Aug 01; 8(4):399-406. PubMed ID: 15288250
    [Abstract] [Full Text] [Related]

  • 14. Preclinical formulations for discovery and toxicology: physicochemical challenges.
    Neervannan S.
    Expert Opin Drug Metab Toxicol; 2006 Oct 01; 2(5):715-31. PubMed ID: 17014391
    [Abstract] [Full Text] [Related]

  • 15. Fragment-based lead discovery: a chemical update.
    Erlanson DA.
    Curr Opin Biotechnol; 2006 Dec 01; 17(6):643-52. PubMed ID: 17084612
    [Abstract] [Full Text] [Related]

  • 16. An efficient in silico screening method based on the protein-compound affinity matrix and its application to the design of a focused library for cytochrome P450 (CYP) ligands.
    Fukunishi Y, Hojo S, Nakamura H.
    J Chem Inf Model; 2006 Dec 01; 46(6):2610-22. PubMed ID: 17125201
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Does human pharmacokinetic prediction add significant value to compound selection in drug discovery research?
    Beaumont K, Smith DA.
    Curr Opin Drug Discov Devel; 2009 Jan 01; 12(1):61-71. PubMed ID: 19152214
    [Abstract] [Full Text] [Related]

  • 19. Ligand-based vascular targeting of disease.
    Rybak JN, Trachsel E, Scheuermann J, Neri D.
    ChemMedChem; 2007 Jan 01; 2(1):22-40. PubMed ID: 17154429
    [Abstract] [Full Text] [Related]

  • 20. Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era.
    Frye SV.
    Chem Biol; 1999 Jan 01; 6(1):R3-7. PubMed ID: 9889153
    [Abstract] [Full Text] [Related]


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