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Journal Abstract Search

131 related items for PubMed ID: 17276985

  • 1. Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.
    Losasso C, Cretaio E, Palle K, Pattarello L, Bjornsti MA, Benedetti P.
    J Biol Chem; 2007 Mar 30; 282(13):9855-9864. PubMed ID: 17276985
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  • 2. Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.
    van der Merwe M, Bjornsti MA.
    J Biol Chem; 2008 Feb 08; 283(6):3305-3315. PubMed ID: 18056711
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  • 3. Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.
    Fiorani P, Amatruda JF, Silvestri A, Butler RH, Bjornsti MA, Benedetti P.
    Mol Pharmacol; 1999 Dec 08; 56(6):1105-15. PubMed ID: 10570037
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  • 4. Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.
    Woo MH, Vance JR, Marcos AR, Bailly C, Bjornsti MA.
    J Biol Chem; 2002 Feb 08; 277(6):3813-22. PubMed ID: 11733535
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  • 5. Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.
    Fertala J, Vance JR, Pourquier P, Pommier Y, Bjornsti MA.
    J Biol Chem; 2000 May 19; 275(20):15246-53. PubMed ID: 10809761
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  • 6. Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.
    Colley WC, van der Merwe M, Vance JR, Burgin AB, Bjornsti MA.
    J Biol Chem; 2004 Dec 24; 279(52):54069-78. PubMed ID: 15489506
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  • 7. Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA.
    Hann CL, Carlberg AL, Bjornsti MA.
    J Biol Chem; 1998 Nov 20; 273(47):31519-27. PubMed ID: 9813066
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  • 8. Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae.
    Fiorani P, Bjornsti MA.
    Ann N Y Acad Sci; 2000 Nov 20; 922():65-75. PubMed ID: 11193926
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  • 10. Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.
    Fiorani P, Bruselles A, Falconi M, Chillemi G, Desideri A, Benedetti P.
    J Biol Chem; 2003 Oct 31; 278(44):43268-75. PubMed ID: 12904303
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  • 12. Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.
    Tesauro C, Morozzo della Rocca B, Ottaviani A, Coletta A, Zuccaro L, Arnò B, D'Annessa I, Fiorani P, Desideri A.
    Mol Cancer; 2013 Sep 03; 12(1):100. PubMed ID: 24004603
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  • 17. Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.
    Woo MH, Losasso C, Guo H, Pattarello L, Benedetti P, Bjornsti MA.
    Proc Natl Acad Sci U S A; 2003 Nov 25; 100(24):13767-72. PubMed ID: 14585933
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  • 18. Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.
    Palle K, Pattarello L, van der Merwe M, Losasso C, Benedetti P, Bjornsti MA.
    J Biol Chem; 2008 Oct 10; 283(41):27767-27775. PubMed ID: 18693244
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  • 19. Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I.
    Das BB, Sen N, Roy A, Dasgupta SB, Ganguly A, Mohanta BC, Dinda B, Majumder HK.
    Nucleic Acids Res; 2006 Oct 10; 34(4):1121-32. PubMed ID: 16488884
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