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172 related items for PubMed ID: 17292610

  • 1. Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist.
    Kainuma M, Makishima M, Hashimoto Y, Miyachi H.
    Bioorg Med Chem; 2007 Apr 01; 15(7):2587-600. PubMed ID: 17292610
    [Abstract] [Full Text] [Related]

  • 2. 5Alpha-bile alcohols function as farnesoid X receptor antagonists.
    Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M.
    Biochem Biophys Res Commun; 2006 Jan 06; 339(1):386-91. PubMed ID: 16300737
    [Abstract] [Full Text] [Related]

  • 3. Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
    Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Madauss KP, Marr HB, McFadyen RB, Miller AB, Parks DJ, Todd D, Williams SP, Wisely GB.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):2969-73. PubMed ID: 19410460
    [Abstract] [Full Text] [Related]

  • 4. Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.
    Deng G, Li W, Shen J, Jiang H, Chen K, Liu H.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5497-502. PubMed ID: 18815030
    [Abstract] [Full Text] [Related]

  • 5. Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp.
    Nam SJ, Ko H, Shin M, Ham J, Chin J, Kim Y, Kim H, Shin K, Choi H, Kang H.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5398-402. PubMed ID: 16905319
    [Abstract] [Full Text] [Related]

  • 6. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
    Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S.
    J Med Chem; 2006 Jul 13; 49(14):4208-15. PubMed ID: 16821780
    [Abstract] [Full Text] [Related]

  • 7. Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity.
    Nam SJ, Ko H, Ju MK, Hwang H, Chin J, Ham J, Lee B, Lee J, Won DH, Choi H, Ko J, Shin K, Oh T, Kim S, Rho JR, Kang H.
    J Nat Prod; 2007 Nov 13; 70(11):1691-5. PubMed ID: 17988093
    [Abstract] [Full Text] [Related]

  • 8. FXR: a promising target for the metabolic syndrome?
    Cariou B, Staels B.
    Trends Pharmacol Sci; 2007 May 13; 28(5):236-43. PubMed ID: 17412431
    [Abstract] [Full Text] [Related]

  • 9. Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.
    Martínez-Fernández P, Hierro L, Jara P, Alvarez L.
    Am J Physiol Gastrointest Liver Physiol; 2009 May 13; 296(5):G1119-29. PubMed ID: 19228886
    [Abstract] [Full Text] [Related]

  • 10. Hologram quantitative structure-activity relationships for a series of farnesoid X receptor activators.
    Honorio KM, Garratt RC, Andricopulo AD.
    Bioorg Med Chem Lett; 2005 Jun 15; 15(12):3119-25. PubMed ID: 15893927
    [Abstract] [Full Text] [Related]

  • 11. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
    Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA.
    Org Biomol Chem; 2003 Mar 21; 1(6):908-20. PubMed ID: 12929628
    [Abstract] [Full Text] [Related]

  • 12. 3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists.
    Zhang T, Zhou JH, Shi LW, Zhu RX, Chen MB.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2156-60. PubMed ID: 17307356
    [Abstract] [Full Text] [Related]

  • 13. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
    Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A.
    J Med Chem; 2004 Aug 26; 47(18):4559-69. PubMed ID: 15317466
    [Abstract] [Full Text] [Related]

  • 14. Targeting farnesoid X receptor for liver and metabolic disorders.
    Fiorucci S, Rizzo G, Donini A, Distrutti E, Santucci L.
    Trends Mol Med; 2007 Jul 26; 13(7):298-309. PubMed ID: 17588816
    [Abstract] [Full Text] [Related]

  • 15. Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligand.
    Takahashi M, Kanayama T, Yashiro T, Kondo H, Murase T, Hase T, Tokimitsu I, Nishikawa J, Sato R.
    Biochem Biophys Res Commun; 2008 Aug 01; 372(3):395-9. PubMed ID: 18457666
    [Abstract] [Full Text] [Related]

  • 16. Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents.
    Lin HR, Abraham DJ.
    Bioorg Med Chem Lett; 2006 Aug 15; 16(16):4178-83. PubMed ID: 16784849
    [Abstract] [Full Text] [Related]

  • 17. The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis.
    Cariou B.
    Diabetes Metab; 2008 Dec 15; 34(6 Pt 2):685-91. PubMed ID: 19195631
    [Abstract] [Full Text] [Related]

  • 18. Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism.
    Huang H, Si P, Wang L, Xu Y, Xu X, Zhu J, Jiang H, Li W, Chen L, Li J.
    ChemMedChem; 2015 Jul 15; 10(7):1184-99. PubMed ID: 25982493
    [Abstract] [Full Text] [Related]

  • 19. The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression.
    Swales KE, Korbonits M, Carpenter R, Walsh DT, Warner TD, Bishop-Bailey D.
    Cancer Res; 2006 Oct 15; 66(20):10120-6. PubMed ID: 17047076
    [Abstract] [Full Text] [Related]

  • 20. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia.
    Evans MJ, Mahaney PE, Borges-Marcucci L, Lai K, Wang S, Krueger JA, Gardell SJ, Huard C, Martinez R, Vlasuk GP, Harnish DC.
    Am J Physiol Gastrointest Liver Physiol; 2009 Mar 15; 296(3):G543-52. PubMed ID: 19136377
    [Abstract] [Full Text] [Related]

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