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228 related items for PubMed ID: 1732039

  • 1. Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.
    Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W.
    Cancer Res; 1992 Feb 01; 52(3):533-9. PubMed ID: 1732039
    [Abstract] [Full Text] [Related]

  • 2. Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine.
    Xu YZ, Plunkett W.
    Biochem Pharmacol; 1992 Nov 03; 44(9):1819-27. PubMed ID: 1449536
    [Abstract] [Full Text] [Related]

  • 3. Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine.
    van Haperen VW, Veerman G, Vermorken JB, Pinedo HM, Peters G.
    Biochem Pharmacol; 1996 Apr 12; 51(7):911-8. PubMed ID: 8651941
    [Abstract] [Full Text] [Related]

  • 4. Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours.
    Ruiz van Haperen VW, Veerman G, Boven E, Noordhuis P, Vermorken JB, Peters GJ.
    Biochem Pharmacol; 1994 Oct 07; 48(7):1327-39. PubMed ID: 7945430
    [Abstract] [Full Text] [Related]

  • 5. Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase.
    Bouffard DY, Laliberté J, Momparler RL.
    Biochem Pharmacol; 1993 May 05; 45(9):1857-61. PubMed ID: 8494545
    [Abstract] [Full Text] [Related]

  • 6. Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine.
    Heinemann V, Hertel LW, Grindey GB, Plunkett W.
    Cancer Res; 1988 Jul 15; 48(14):4024-31. PubMed ID: 3383195
    [Abstract] [Full Text] [Related]

  • 7. Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.
    Grunewald R, Kantarjian H, Keating MJ, Abbruzzese J, Tarassoff P, Plunkett W.
    Cancer Res; 1990 Nov 01; 50(21):6823-6. PubMed ID: 2208147
    [Abstract] [Full Text] [Related]

  • 8. Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome.
    Jiang HY, Hickey RJ, Abdel-Aziz W, Malkas LH.
    Cancer Chemother Pharmacol; 2000 Nov 01; 45(4):320-8. PubMed ID: 10755321
    [Abstract] [Full Text] [Related]

  • 9. Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study.
    Grunewald R, Kantarjian H, Du M, Faucher K, Tarassoff P, Plunkett W.
    J Clin Oncol; 1992 Mar 01; 10(3):406-13. PubMed ID: 1740680
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.
    Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W.
    Mol Pharmacol; 1990 Oct 01; 38(4):567-72. PubMed ID: 2233693
    [Abstract] [Full Text] [Related]

  • 11. Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
    Heinemann V, Schulz L, Issels RD, Plunkett W.
    Semin Oncol; 1995 Aug 01; 22(4 Suppl 11):11-8. PubMed ID: 7481839
    [Abstract] [Full Text] [Related]

  • 12. Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.
    van Moorsel CJ, Bergman AM, Veerman G, Voorn DA, Ruiz van Haperen VW, Kroep JR, Pinedo HM, Peters GJ.
    Biochim Biophys Acta; 2000 Mar 06; 1474(1):5-12. PubMed ID: 10699484
    [Abstract] [Full Text] [Related]

  • 13. Action of 2',2'-difluorodeoxycytidine on DNA synthesis.
    Huang P, Chubb S, Hertel LW, Grindey GB, Plunkett W.
    Cancer Res; 1991 Nov 15; 51(22):6110-7. PubMed ID: 1718594
    [Abstract] [Full Text] [Related]

  • 14. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides.
    Derissen EJB, Huitema ADR, Rosing H, Schellens JHM, Beijnen JH.
    Br J Clin Pharmacol; 2018 Jun 15; 84(6):1279-1289. PubMed ID: 29451684
    [Abstract] [Full Text] [Related]

  • 15. Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine.
    Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W.
    Cancer Chemother Pharmacol; 1991 Jun 15; 27(4):258-62. PubMed ID: 1998982
    [Abstract] [Full Text] [Related]

  • 16. Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.
    Smid K, Van Moorsel CJ, Noordhuis P, Voorn DA, Peters GJ.
    Int J Oncol; 2001 Jul 15; 19(1):157-62. PubMed ID: 11408937
    [Abstract] [Full Text] [Related]

  • 17. Cellular pharmacology of gemcitabine.
    Mini E, Nobili S, Caciagli B, Landini I, Mazzei T.
    Ann Oncol; 2006 May 15; 17 Suppl 5():v7-12. PubMed ID: 16807468
    [Abstract] [Full Text] [Related]

  • 18. Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine.
    Heinemann V, Plunkett W.
    Biochem Pharmacol; 1989 Nov 15; 38(22):4115-21. PubMed ID: 2688654
    [Abstract] [Full Text] [Related]

  • 19. Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase.
    Momparler RL, Rossi M, Bouchard J, Vaccaro C, Momparler LF, Bartolucci S.
    Mol Pharmacol; 1984 May 15; 25(3):436-40. PubMed ID: 6203026
    [Abstract] [Full Text] [Related]

  • 20. Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.
    Bergman AM, Munch-Petersen B, Jensen PB, Sehested M, Veerman G, Voorn DA, Smid K, Pinedo HM, Peters GJ.
    Biochem Pharmacol; 2001 Jun 01; 61(11):1401-8. PubMed ID: 11331076
    [Abstract] [Full Text] [Related]

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