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94 related items for PubMed ID: 17336492

  • 1. A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.
    Kienhuis AS, Wortelboer HM, Maas WJ, van Herwijnen M, Kleinjans JC, van Delft JH, Stierum RH.
    Toxicol In Vitro; 2007 Aug; 21(5):892-901. PubMed ID: 17336492
    [Abstract] [Full Text] [Related]

  • 2. Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.
    Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH.
    Drug Metab Dispos; 2006 Dec; 34(12):2083-90. PubMed ID: 16963487
    [Abstract] [Full Text] [Related]

  • 3. Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.
    Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH.
    Drug Metab Dispos; 2009 Jun; 37(6):1305-11. PubMed ID: 19251822
    [Abstract] [Full Text] [Related]

  • 4. Effects of cell culture conditions on primary rat hepatocytes-cell morphology and differential gene expression.
    Tuschl G, Mueller SO.
    Toxicology; 2006 Feb 01; 218(2-3):205-15. PubMed ID: 16337326
    [Abstract] [Full Text] [Related]

  • 5. Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture.
    Langsch A, Giri S, Acikgöz A, Jasmund I, Frericks B, Bader A.
    Toxicol Lett; 2009 Aug 10; 188(3):173-9. PubMed ID: 19428196
    [Abstract] [Full Text] [Related]

  • 6. Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug-drug interaction studies.
    Tuschl G, Hrach J, Walter Y, Hewitt PG, Mueller SO.
    Chem Biol Interact; 2009 Sep 14; 181(1):124-37. PubMed ID: 19482013
    [Abstract] [Full Text] [Related]

  • 7. Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems.
    Boess F, Kamber M, Romer S, Gasser R, Muller D, Albertini S, Suter L.
    Toxicol Sci; 2003 Jun 14; 73(2):386-402. PubMed ID: 12657743
    [Abstract] [Full Text] [Related]

  • 8. Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.
    Ringel M, von Mach MA, Santos R, Feilen PJ, Brulport M, Hermes M, Bauer AW, Schormann W, Tanner B, Schön MR, Oesch F, Hengstler JG.
    Toxicology; 2005 Jan 05; 206(1):153-67. PubMed ID: 15590115
    [Abstract] [Full Text] [Related]

  • 9. Well maintained expression of CYP genes in sandwich-culturing hepatocytes: quantitative analysis using real-time PCR method.
    Toritsuka N, Nonogaki Y, Hori Y, Sawada S, Shoun H, Motooka S.
    Res Commun Mol Pathol Pharmacol; 2001 Jan 05; 110(5-6):311-8. PubMed ID: 12889523
    [Abstract] [Full Text] [Related]

  • 10. Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes.
    Richert L, Tuschl G, Abadie C, Blanchard N, Pekthong D, Mantion G, Weber JC, Mueller SO.
    Toxicol Appl Pharmacol; 2009 Feb 15; 235(1):86-96. PubMed ID: 19118567
    [Abstract] [Full Text] [Related]

  • 11. Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells.
    Lambert CB, Spire C, Claude N, Guillouzo A.
    Toxicol Appl Pharmacol; 2009 Feb 01; 234(3):345-60. PubMed ID: 19084549
    [Abstract] [Full Text] [Related]

  • 12. Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures.
    Pekthong D, Blanchard N, Abadie C, Bonet A, Heyd B, Mantion G, Berthelot A, Richert L, Martin H.
    Chem Biol Interact; 2009 May 15; 179(2-3):247-55. PubMed ID: 19041297
    [Abstract] [Full Text] [Related]

  • 13. Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.
    Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A.
    Toxicol Appl Pharmacol; 2009 Jan 15; 234(2):179-91. PubMed ID: 18983865
    [Abstract] [Full Text] [Related]

  • 14. Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating.
    Richert L, Liguori MJ, Abadie C, Heyd B, Mantion G, Halkic N, Waring JF.
    Drug Metab Dispos; 2006 May 15; 34(5):870-9. PubMed ID: 16473918
    [Abstract] [Full Text] [Related]

  • 15. Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.
    Mingoia RT, Nabb DL, Yang CH, Han X.
    Toxicol In Vitro; 2007 Feb 15; 21(1):165-73. PubMed ID: 17141466
    [Abstract] [Full Text] [Related]

  • 16. Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.
    Lauer B, Tuschl G, Kling M, Mueller SO.
    Chem Biol Interact; 2009 Apr 15; 179(1):17-24. PubMed ID: 19022234
    [Abstract] [Full Text] [Related]

  • 17. Liverbeads: a practical and relevant in vitro model for gene induction investigations.
    Al Khansa I, Blanck O, Guillouzo A, Bars R.
    Drug Metab Dispos; 2010 Sep 15; 38(9):1598-604. PubMed ID: 20551240
    [Abstract] [Full Text] [Related]

  • 18. Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.
    Werle-Schneider G, Wölfelschneider A, von Brevern MC, Scheel J, Storck T, Müller D, Glöckner R, Bartsch H, Bartelmann M.
    Int J Toxicol; 2006 Sep 15; 25(5):379-95. PubMed ID: 16940010
    [Abstract] [Full Text] [Related]

  • 19. Assessment of hepatocytes and liver slices as in vitro test systems to predict in vivo gene expression.
    Jessen BA, Mullins JS, De Peyster A, Stevens GJ.
    Toxicol Sci; 2003 Sep 15; 75(1):208-22. PubMed ID: 12832660
    [Abstract] [Full Text] [Related]

  • 20. Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures.
    Schmelzer E, Acikgoez A, Frühauf NR, Crome O, Klempnauer J, Christians U, Bader A.
    Xenobiotica; 2006 Aug 15; 36(8):693-708. PubMed ID: 16891250
    [Abstract] [Full Text] [Related]

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