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Journal Abstract Search

215 related items for PubMed ID: 17346178

  • 1. Dihydrofolate reductase as a target for chemotherapy in parasites.
    Gangjee A, Kurup S, Namjoshi O.
    Curr Pharm Des; 2007; 13(6):609-39. PubMed ID: 17346178
    [Abstract] [Full Text] [Related]

  • 2. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.
    Gangjee A, Jain HD, Kurup S.
    Anticancer Agents Med Chem; 2007 Sep; 7(5):524-42. PubMed ID: 17896913
    [Abstract] [Full Text] [Related]

  • 3. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
    Rosowsky A, Forsch RA, Queener SF.
    J Med Chem; 2003 Apr 24; 46(9):1726-36. PubMed ID: 12699390
    [Abstract] [Full Text] [Related]

  • 4. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
    Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF.
    J Med Chem; 2004 Mar 11; 47(6):1475-86. PubMed ID: 14998335
    [Abstract] [Full Text] [Related]

  • 5. Anticancer antifolates: current status and future directions.
    McGuire JJ.
    Curr Pharm Des; 2003 Mar 11; 9(31):2593-613. PubMed ID: 14529544
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
    Chan DC, Fu H, Forsch RA, Queener SF, Rosowsky A.
    J Med Chem; 2005 Jun 30; 48(13):4420-31. PubMed ID: 15974594
    [Abstract] [Full Text] [Related]

  • 7. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
    Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER.
    J Med Chem; 1996 Mar 15; 39(6):1271-80. PubMed ID: 8632434
    [Abstract] [Full Text] [Related]

  • 8. Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
    Assaraf YG, Slotky JI.
    J Biol Chem; 1993 Feb 25; 268(6):4556-66. PubMed ID: 8440739
    [Abstract] [Full Text] [Related]

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  • 10. Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.
    Gangjee A, Jain HD, Kurup S.
    Anticancer Agents Med Chem; 2008 Feb 25; 8(2):205-31. PubMed ID: 18288923
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
    Rosowsky A, Forsch RA, Queener SF.
    J Med Chem; 2002 Jan 03; 45(1):233-41. PubMed ID: 11754594
    [Abstract] [Full Text] [Related]

  • 12. Regulation of human dihydrofolate reductase activity and expression.
    Abali EE, Skacel NE, Celikkaya H, Hsieh YC.
    Vitam Horm; 2008 Jan 03; 79():267-92. PubMed ID: 18804698
    [Abstract] [Full Text] [Related]

  • 13. Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors.
    Wróbel A, Arciszewska K, Maliszewski D, Drozdowska D.
    J Antibiot (Tokyo); 2020 Jan 03; 73(1):5-27. PubMed ID: 31578455
    [Abstract] [Full Text] [Related]

  • 14. Mutational analysis confirms the presence of distal inhibitor-selectivity determining residues in B. stearothermophilus dihydrofolate reductase.
    Eck T, Patel S, Candela T, Leon H K, Little M, Reis NE, Liyanagunawardana U, Gubler U, Janson CA, Catalano J, Goodey NM.
    Arch Biochem Biophys; 2020 Oct 15; 692():108545. PubMed ID: 32810476
    [Abstract] [Full Text] [Related]

  • 15. Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.
    Abdizadeh H, Tamer YT, Acar O, Toprak E, Atilgan AR, Atilgan C.
    Phys Chem Chem Phys; 2017 May 10; 19(18):11416-11428. PubMed ID: 28422217
    [Abstract] [Full Text] [Related]

  • 16. Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
    Rosowsky A, Fu H, Chan DC, Queener SF.
    J Med Chem; 2004 May 06; 47(10):2475-85. PubMed ID: 15115391
    [Abstract] [Full Text] [Related]

  • 17. Dihydrofolate reductase as a therapeutic target.
    Schweitzer BI, Dicker AP, Bertino JR.
    FASEB J; 1990 May 06; 4(8):2441-52. PubMed ID: 2185970
    [Abstract] [Full Text] [Related]

  • 18. Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols.
    Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF.
    Drug Metab Dispos; 2008 Mar 06; 36(3):508-16. PubMed ID: 18056255
    [Abstract] [Full Text] [Related]

  • 19. 2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
    Rosowsky A, Forsch RA, Queener SF.
    J Med Chem; 1995 Jul 07; 38(14):2615-20. PubMed ID: 7629801
    [Abstract] [Full Text] [Related]

  • 20. Cancer research: from folate antagonism to molecular targets.
    Bertino JR.
    Best Pract Res Clin Haematol; 2009 Dec 07; 22(4):577-82. PubMed ID: 19959110
    [Abstract] [Full Text] [Related]

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