These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1. Rowbottom MW, Vickers TD, Dyck B, Grey J, Tamiya J, Zhang M, Kiankarimi M, Wu D, Dwight W, Wade WS, Schwarz D, Heise CE, Madan A, Fisher A, Petroski R, Goodfellow VS. Bioorg Med Chem Lett; 2006 Sep 01; 16(17):4450-7. PubMed ID: 16814542 [Abstract] [Full Text] [Related]
3. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T. Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3674-8. PubMed ID: 16690315 [Abstract] [Full Text] [Related]
4. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists. Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T. Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3072-7. PubMed ID: 19403308 [Abstract] [Full Text] [Related]
5. Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists. Ma V, Bannon AW, Baumgartner J, Hale C, Hsieh F, Hulme C, Rorrer K, Salon J, van Staden C, Tempest P. Bioorg Med Chem Lett; 2006 Oct 01; 16(19):5066-72. PubMed ID: 16887348 [Abstract] [Full Text] [Related]
6. Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists. Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F. Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4859-63. PubMed ID: 18682323 [Abstract] [Full Text] [Related]
7. Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists. Lim CJ, Kim JY, Lee BH, Oh KS, Yi KY. Bioorg Med Chem Lett; 2013 Mar 15; 23(6):1736-9. PubMed ID: 23411080 [Abstract] [Full Text] [Related]
8. Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists. Arienzo R, Clark DE, Cramp S, Daly S, Dyke HJ, Lockey P, Norman D, Roach AG, Stuttle K, Tomlinson M, Wong M, Wren SP. Bioorg Med Chem Lett; 2004 Aug 02; 14(15):4099-102. PubMed ID: 15225734 [Abstract] [Full Text] [Related]
9. Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Beeley N, Sekiguchi Y. Bioorg Med Chem Lett; 2005 May 16; 15(10):2565-9. PubMed ID: 15863317 [Abstract] [Full Text] [Related]
10. Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents. Warshakoon NC, Sheville J, Bhatt RT, Ji W, Mendez-Andino JL, Meyers KM, Kim N, Wos JA, Mitchell C, Paris JL, Pinney BB, Reizes O, Hu XE. Bioorg Med Chem Lett; 2006 Oct 01; 16(19):5207-11. PubMed ID: 16870427 [Abstract] [Full Text] [Related]
11. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas. McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. J Med Chem; 2006 Apr 06; 49(7):2294-310. PubMed ID: 16570926 [Abstract] [Full Text] [Related]
12. Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives. Kasai S, Kamaura M, Kamata M, Aso K, Ogino H, Nakano Y, Watanabe K, Kaisho T, Tawada M, Nagisa Y, Takekawa S, Kato K, Suzuki N, Ishihara Y. Bioorg Med Chem; 2011 Nov 01; 19(21):6261-73. PubMed ID: 21975069 [Abstract] [Full Text] [Related]
13. Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists. Balavoine F, Malabre P, Alleaume T, Rey A, Cherfils V, Jeanneton O, Seigneurin-Venin S, Revah F. Bioorg Med Chem Lett; 2007 Jul 01; 17(13):3754-9. PubMed ID: 17448659 [Abstract] [Full Text] [Related]
14. The discovery and optimization of pyrimidinone-containing MCH R1 antagonists. Hertzog DL, Al-Barazanji KA, Bigham EC, Bishop MJ, Britt CS, Carlton DL, Cooper JP, Daniels AJ, Garrido DM, Goetz AS, Grizzle MK, Guo YC, Handlon AL, Ignar DM, Morgan RO, Peat AJ, Tavares FX, Zhou H. Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4723-7. PubMed ID: 16870432 [Abstract] [Full Text] [Related]
15. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Wu WL, Burnett DA, Spring R, Qiang L, Sasikumar TK, Domalski MS, Greenlee WJ, O'Neill K, Hawes BE. Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3668-73. PubMed ID: 16690312 [Abstract] [Full Text] [Related]
16. 4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1). Lim CJ, Kim SH, Lee BH, Oh KS, Yi KY. Bioorg Med Chem Lett; 2012 Jan 01; 22(1):427-30. PubMed ID: 22137790 [Abstract] [Full Text] [Related]
17. Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis. Su J, McKittrick BA, Tang H, Czarniecki M, Greenlee WJ, Hawes BE, O'Neill K. Bioorg Med Chem; 2005 Mar 01; 13(5):1829-36. PubMed ID: 15698800 [Abstract] [Full Text] [Related]
18. Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Mihalic JT, Chen X, Fan P, Chen X, Fu Y, Liang L, Reed M, Tang L, Chen JL, Jaen J, Li L, Dai K. Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7001-5. PubMed ID: 22019296 [Abstract] [Full Text] [Related]